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HTRA1 (NM_002775) Human Untagged Clone
CAT＃: SC118403
HTRA1 (untagged)-Human HtrA serine peptidase 1 (HTRA1)
CNY 3,656.00
CNY 7,700.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ARMD7; CADASIL2; CARASIL; HtrA; L56; ORF480; PRSS11 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_002775 edited
GAATTCGGCACGAGGCTCCGGCCCTCGCCCTGTCCGCCGCCACCGCCGCCGCCGCCAGAG TCGCCATGCAGATCCCGCGCGCCGCTCTTCTCCCGCTGCTGCTGCTGCTGCTGGCGGCGC CCGCCTCGGCGCAGCTGTCCCGGGCCGGCCGCTCGGCGCCTTTGGCTGCCGGTTGCCCAG ACCGCTGCGAGCCGGCGCGCTGCCCGCCGCAGCCGGAGCACTGCGAGGGCGGCCGGGCCC GGGACGCGTGCGGCTGCTGCGAGGTGTGCGGCGCGCCCGAGGGCGCCGCGTGCGGCCTGC AGGAGGGCCCGTGCGGCGAGGGGCTGCAGTGCGTGGTGCCCTTCGGGGTGCCAGCCTCGG CCACGGTGCGGCGGCGCGCGCAGGCCGGCCTCTGTGTGTGCGCCAGCAGCGAGCCGGTGT GCGGCAGCGACGCCAACACCTACGCCAACCTGTGCCAGCTGCGCGCCGCCAGCCGCCGCT CCGAGAGGCTGCACCGGCCGCCGGTCATCGTCCTGCAGCGCGGAGCCTGCGGCCAAGGGC AGGAAGATCCCAACAGTTTGCGCCATAAATATAACTTTATCGCGGACGTGGTGGAGAAGA TCGCCCCTGCCGTGGTTCATATCGAATTGTTTCGCAAGCTTCCGTTTTCTAAACGAGAGG TGCCGGTGGCTAGTGGGTCTGGGTTTATTGTGTCGGAAGATGGACTGATCGTGACAAATG CCCACGTGGTGACCAACAAGCACCGGGTCAAAGTTGAGCTGAAGAACGGTGCCACTTACG AAGCCAAAATCAAGGATGTGGATGAGAAAGCAGACATCGCACTCATCAAAATTGACCACC AGGGCAAGCTGCCTGTCCTGCTGCTTGGCCGCTCCTCAGAGCTGCGGCCGGGAGAGTTCG TGGTCGCCATCGGAAGCCCGTTTTCCCTTCAAAACACAGTCACCACCGGGATCGTGAGCA CCACCCAGCGAGGCGGCAAAGAGCTGGGGCTCCGCAACTCAGACATGGACTACATCCAGA CCGACGCCATCATCAACTATGGAAACTCGGGAGGCCCGTTAGTAAACCTGGACGGTGAAG TGATTGGAATTAACACTTTGAAAGTGACAGCTGGAATCTCCTTTGCAATCCCATCTGATA AGATTAAAAAGTTCCTCACGGAGTCCCATGACCGACAGGCCAAAGGAAAAGCCATCACCA AGAAGAAGTATATTGGTATCCGAATGATGTCACTCACGTCCAGCAAAGCCAAAGAGCTGA AGGACCGGCACCGGGACTTCCCAGACGTGATCTCAGGAGCGTATATAATTGAAGTAATTC CTGATACCCCAGCAGAAGCTGGTGGTCTCAAGGAAAACGACGTCATAATCAGCATCAATG GACAGTCCGTGGTCTCCGCCAATGATGTCAGCGACGTCATTAAAAGGGAAAGCACCCTGA ACATGGTGGTCCGCAGGGGTAATGAAGATATCATGATCACAGTGATTCCCGAAGAAATTG ACCCATAGGCAGAGGCATGAGCTGGACTTCATGTTTCCCTCAAAGACTCTCCCGTGGATG ACGGATGAGGACTCTGGGCTGCTGGAATAGGACACTCAAGACTTTTGACTGCCATTTTGT TTGTTCAGTGGAGACTCCCTGGCCAACAGAATCCTTCTTGATAGTTTGCAGGCAAAACAA ATGTAATGTTGCAGATCCGCAGGCAGAAGCTCTGCCCTTCTGTATCCTATGTATGCAGTG TGCTTTTTCTTGCCAGCTTGGGCCATTCTTGCTTAGACAGTCAGCATTTGTCTCCTCCTT TAACTGAGTCATCATCTTAGTCCAACTAATGCAGTCGATACAATGCGTAGATAGAAGAAG CCCCACGGGAGCCAGGATGGGACTGGTCGTGTTTGTGCTTTTCTCCAAGTCAGCACCCAA AGGTCAATGCACAGAGACCCCGGGTGGGTGAGCGCTGGCTTCTCAAACGGCCGAAGTTGC CTCTTTTAGGAATCTCTTTGGAATTGGGAGCACGATGACTCTGAGTTTGAGCTATTAAAG TACTTCTTACACATTGAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_002775 unedited
CAGATTTTGTAATACGACTCACTTATAGGGCGGCCGCGAATCGGCACGAGGCTCCGGCCC TCGCCCTGTCCGCCGCCACCGCCGCCGCCGCCAGAGTCGCCATGCAGATCCCGCGCGCCG CTCTTCTCCCGCTGCTGCTGCTGCTGCTGGCGGCGCCCGCCTCGGCGCAGCTGTCCCGGG CCGGCCGCTCGGCGCCTTTGGCTGCCGGTTGCCCAGACCGCTGCGAGCCGGCGCGCTGCC CGCCGCAGCCGGAGCACTGCGAGGGCGGCCGGGCCCGGGACGCGTGCGGCTGCTGCGAGG TGTGCGGCGCGCCCGAGGGCGCCGCGTGCGGCCTGCAGGAGGGCCCGTGCGGCGAGGGGC TGCAGTGCGTGGTGCCCTTCGGGGTGCCAGCCTCGGCCACGGTGCGGCGGCGCGCGCAGG CCGGCCTCTGTGTGTGCGCCAGCAGCGAGCCGGTGTGCGGCAGCGACGCCAACACCTACG CCAACCTGTGCCAGCTGCGCGCCGCCAGCCGCCGCTCCGAGAGGCTGCACCGGCCGCCGG TCATCGTCCTGCAGCGCGGAGCCTGCGGCCAAGGGCAGGAAGATCCCAACAGTTTGCGCC ATAAATATAACTTTATCGCGGACGTGGTGGAGAAGATCGCCCCTGCCGTGGTTCATATCG AATTGTTTCGCAAGCTTCCGTTTTCTAAACGAGAGGTGCCGGTGGCTAGTGGGTCTGGGT TTATTGTGTCGGAAGATGGACTGATCGTGACANATGCCCACGTGGTGACCAACAAGCACC GGGTCAAAAGTGAGCTGAAGAACGGTGCCACTTACGAAGCCAAATCAAGGATGGGGATGA GAAAGCAGACATCGCACTCATCAAAATTGACCACCCGGGGCAGCCTGCCTGTCCTGCTGC TTGGCCGCTCCTCAGAGCTGCGCCGGGAAGAATTCGTGTCGCCATCGGAAGACCCTT >OriGene 3' read for NM_002775 unedited
CTTTGGACCGGCGGCCGCAATCTANGATCGAGTTTTTTTTTTTTTTTTTTAAATGTGTAA GAAGTACTTTAATAGCTCAAACTCAGAGTCATCGTGCTCCCAATTCCAAAAAGATTCCTA AAAGAGGCAACTTCGGCCGTTTGAGAAGCCAGCGCTCACCCACCCGGGGTCTCTGTGCAT TGACCTTTGGGTGCTGACTTGGAGAAAAGCACAAACACGACCAGTCCCATCCTGGCTCCC GTGGGGCTTCTTCTATCTACGCATTGTATCGACTGCATTAGTTGGACTAAGATGATGACT CAGTTAAAGGAGGAGACAAATGCTGACTGTCTAAGCAAGAATGGCCCAAGCTGGCAAGAA AAAGCACACTGCATACATAGGATACAGAAGGGCAGAGCTTCTGCCTGCGGATCTGCAACA TTACATTTGTTTTGCCTGCAAACTATCAAGAAGGATTCTGTTGGCCAGGGAGTCTCCACT GAACAAACAAAATGGCAGTCAAAAGTCTTGAGTGTCCTATTCCAGCAGCCCAGAGTCCTC ATCCGTCATCCACGGAAGAGTCTTTGAGGGAAACATGAAGTCCAGCTCATGCCTCTGCCT ATGGGTCAATTTCTTCGGGAATCACTGGGATCATGATATCTTTATTACCCCCTGCGACCA CCATGTTCAGGGGTGCTTTCCCTTTTTAATGACGTCGCTTGACATTCATTGCCGGAAGAC CACGGGACTGTTCCATTGGATGCCTGATTATGACCGTCGTTTTCCCTTGGAAACCCCCAC TTTTTGCTTGGGGTATCAGGAATTTACTTCAATAATTTACCGCTTCCTGGAGATCCCGNT CGGGGAAAGTCCCCGTTGGCCCGGCCCTTTCAGCTTTTTTGCTTTTGCTTGGACCGGAAG GGACTTCATTTGGGATACCAAAAAACCTTTTTTTTGGGGAAAGCTTTTCCCTTGGCGCCG TGCGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002775 |
| Insert Size | 2210 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002775.3, NP_002766.1 |
| RefSeq Size | 2133 bp |
| RefSeq ORF | 1443 bp |
| Locus ID | 5654 |
| UniProt ID | Q92743 |
| Domains | IB, Tryp_SPc, PDZ, kazal |
| Protein Families | Druggable Genome, Protease, Secreted Protein |
| Gene Summary | This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
The serine protease HtrA1 cleaves misfolded transforming growth factor β-induced protein (TGFBIp) and induces amyloid formation
,Poulsen, ET;Nielsen, NS;Scavenius, C;Mogensen, EH;Risør, MW;Runager, K;Lukassen, MV;Rasmussen, CB;Christiansen, G;Richner, M;Vorum, H;Enghild, JJ;,
J. Biol. Chem.
,PubMed ID 31197037
[HTRA1]
|
|
Protoporphyrins Enhance Oligomerization and Enzymatic Activity of HtrA1 Serine Protease
,null,
PLoS ONE
,PubMed ID 25506911
[HTRA1]
|
|
Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-ß1 via cleavage of proTGF-ß1
,Atsushi Shiga, Hiroaki Nozaki, Akio Yokoseki, Megumi Nihonmatsu, Hirotoshi Kawata, Taisuke Kato, Akihide Koyama, Kunimasa Arima, Mari Ikeda, Shinichi Katada, Yasuko Toyoshima, Hitoshi Takahashi, Akira Tanaka, Imaharu Nakano, Takeshi Ikeuchi, Masatoyo Nishizawa, and Osamu Onodera,
Hum. Mol. Genet., Feb 2011; 10.1093/hmg/ddr063
[HTRA1]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC222362 | HTRA1 (Myc-DDK-tagged)-Human HtrA serine peptidase 1 (HTRA1) |
CNY 3,656.00 |
|
| RC222362L1 | Lenti ORF clone of Human HtrA serine peptidase 1 (HTRA1), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC222362L2 | Lenti ORF clone of Human HtrA serine peptidase 1 (HTRA1), mGFP tagged |
CNY 5,890.00 |
|
| RC222362L3 | Lenti ORF clone of Human HtrA serine peptidase 1 (HTRA1), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC222362L4 | Lenti ORF clone of Human HtrA serine peptidase 1 (HTRA1), mGFP tagged |
CNY 6,056.00 |
|
| RG222362 | HTRA1 (tGFP-tagged) - Human HtrA serine peptidase 1 (HTRA1) |
CNY 5,256.00 |
