United States
Germany
Japan
United Kingdom
China
Proprotein Convertase 2 (PCSK2) (NM_002594) Human Untagged Clone
CAT＃: SC118531
PCSK2 (untagged)-Human proprotein convertase subtilisin/kexin type 2 (PCSK2), transcript variant 1
CNY 4,760.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | NEC-2; NEC 2; NEC2; PC2; SPC2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118531 sequence for NM_002594 edited (data generated by NextGen Sequencing)
ATGAAGGGTGGTTGTGTCTCCCAGTGGAAGGCGGCCGCCGGGTTCCTCTTCTGTGTCATG GTTTTTGCATCTGCTGAGCGACCGGTCTTCACGAATCATTTTCTTGTGGAGTTGCATAAA GGGGGAGAGGACAAAGCTCGCCAAGTTGCAGCAGAACACGGCTTTGGAGTCCGAAAGCTT CCCTTTGCTGAAGGTCTGTACCACTTTTATCACAATGGCCTTGCAAAGGCCAAGAGAAGA CGCAGCCTACACCACAAGCAGCAGCTGGAGAGAGACCCCAGGGTAAAGATGGCTTTGCAG CAGGAAGGATTTGACCGAAAAAAGCGAGGTTACAGAGACATCAATGAGATCGACATCAAC ATGAACGATCCTCTTTTTACAAAGCAGTGGTATCTGATCAATACTGGGCAAGCTGATGGC ACTCCTGGCCTTGATTTGAATGTGGCTGAAGCCTGGGAGCTGGGATACACAGGGAAAGGT GTTACCATTGGAATTATGGATGATGGGATTGACTATCTCCACCCGGACCTGGCCTCCAAC TATAATGCCGAAGCAAGTTACGACTTCAGCAGCAACGACCCCTATCCTTACCCTCGGTAC ACAGATGACTGGTTTAACAGCCACGGGACCCGATGTGCAGGAGAAGTTTCTGCTGCCGCC AACAACAATATCTGTGGAGTTGGAGTAGCATACAACTCCAAGGTTGCAGGCATCCGGATG CTGGACCAGCCATTCATGACAGACATCATCGAGGCCTCCTCCATCAGTCATATGCCACAG CTGATTGACATCTACAGCGCCAGCTGGGGCCCCACAGACAACGGCAAGACAGTGGATGGG CCCCGGGAGCTCACGCTGCAGGCCATGGCCGATGGCGTGAACAAGGGCCGCGGCGGCAAA GGCAGCATCTACGTGTGGGCCTCCGGGGACGGCGGCAGCTATGACGACTGCAACTGCGAC GGCTACGCCTCCAGCATGTGGACCATCTCCATCAACTCAGCCATCAACGACGGCAGGACT GCCCTGTACGACGAGAGCTGCTCTTCCACCTTGGCTTCCACCTTCAGCAACGGGAGGAAA AGGAACCCCGAGGCCGGTGTGGCAACCACAGATTTGTACGGCAACTGCACTCTGAGGCAT TCTGGGACATCTGCAGCTGCCCCCGAGGCAGCTGGTGTGTTTGCACTGGCTCTGGAGGCT AACCTGGGTCTGACCTGGCGGGACATGCAGCATCTGACTGTGCTCACCTCCAAACGGAAC CAGCTTCACGACGAGGTCCATCAGTGGCGGCGCAATGGGGTCGGCCTGGAATTTAATCAC CTCTTTGGCTACGGGGTCCTTGATGCAGGTGCCATGGTGAAAATGGCTAAAGACTGGAAA ACCGTGCCTGAGAGATTCCACTGTGTGGGAGGCTCCGTGCAGGACCCTGAGAAAATACCA TCCACTGGCAAGTTGGTGCTGACACTCACAACCGACGCCTGTGAGGGGAAGGAAAATTTT GTCCGCTACCTGGAGCATGTCCAGGCTGTCATCACGGTCAACGCAACCAGAAGAGGAGAC CTGAACATCAACATGACTTCCCCTATGGGCACCAAGTCCATTTTGCTGAGCCGGCGTCCA AGGGATGACGACTCCAAGGTGGGCTTTGACAAGTGGCCTTTCATGACCACTCACACGTGG GGGGAAGACGCCCGAGGCACCTGGACCCTGGAGCTGGGATTTGTCGGCAGCGCCCCGCAG AAGGGGGTGCTGAAGGAGTGGACCCTGATGCTGCATGGCACTCAGAGTGCCCCGTACATC GACCAGGTGGTGCGGGATTACCAGTCCAAGTTGGCCATGTCCAAGAAAGAGGAGCTGGAG GAAGAGCTGGACGAAGCCGTGGAGAGAAGCCTGAAAAGCATCCTTAACAAGAACTAG Clone variation with respect to NM_002594.3 >OriGene 5' read for NM_002594 unedited
GGAATTTGTAATACGACTCACTATAGGGGCGGCCGCGAATTCGCACGAGGCAGCTCCCCA CATTCGCACCCCTGCCCGCGCGCCGGGCCGCCTGACTGCACGGCTTCCCCTCCAGCCAGA TGCTGGAGAACACATACTGATTCGCTGCTTTCCAAGACCCTGTTCAGTCTCTTTCTCTAT ACAAAGATTTTTTTAAAAACTATATATAAGAATTCTTTATTTGCACCCTCCCTCCGAGTC CCCTGCTCCGCCAGCCTGCGCGCCTCCTAGCACCACTTTTCACTCCCAAAGAAGGATGAA GGGTGGTTGTGTCTCCCAGTGGAAGGCGGCCGCCGGGTTCCTCTTCTGTGTCATGGTTTT TGCATCTGCTGAGCGACCGGTCTTCACGAATCATTTTCTTGTGGAGTTGCATAAAGGGGG AGAGGACAAAGCTCGCCAAGTTGCAGCAGAACACGGCTTTGGAGTCCGAAAGCTTCCCTT TGCTGAAGGTCTGTACCACTTTTATCACAATGGCCTTGCAAAGGCCAAGAGAAGACGCAG CCTACACCACAAGCAGCAGCTGGAGAGAGACCCCAGGGTAAAGATGGCTTTGCAGCAGGA AGGATTTGACCGAAAAAAGCGAGGTTACAGAGACATCAATGGAGATCGACATCAACATNG AACGANTCCTCTTTTTACAANAGCAGTGGGGTATCTGATNCAATACTGGGGCAAGCTGAT GGGCACTCCCTGGCCCTTGATTTTGAATGGTGGGCTGAAAGCCTGGNGAGCTGNGATACC AGGNNAAAAGGGTGNTACCATTGGAATNATGGGATGAAGGGGGAATGACTATTCTCCACC CCGGACCCTGGCCTTCAACTATATGGCGAAGGCAAGTTACGACTTCAGAGNNAACGACCC CTATTCTTACCCTCGTCACACGAAGAAGG >OriGene 3' read for NM_002594 unedited
CGCGGCACGCAATCTAGTATCGAGTTTTTTTTTTTTTTTTTTGTTGGGAACGCTATATTT GGGGCATAGAGTAAAAAAGATTGTTTCCATTGTAATGAAAATAATCATTGACAGTGAGTG AAGCTTCAGATTAAGAAGACGGAATTGCCTGTACGGGTGATGGAATTGCTAGGTGCCTGC CTGAAACGTGGAGCGAGGACAGAGGCGGAGCTGGGGAGGGAGGGCGGTGGGAAAGGCGGA TGTGCAGCGCTAGTTCTTGTTAAAGATGCTTTTCAAGCTTCTCTCCACGGCTTCGTCCAG CTCTTCCTCCAGCTCCTCTTTCTTGGACATGGCCAACTTGGACTGGTAATCCCGCACCAC CTGGTCGATGTACGGGGCACTCTGAGTGCCATGCAGCATCAGGGTCCACTCCTTCAGCAC CCCCTTCTGCGGGGCGCTGCCGACAAATCCCAGCTCCAGGGTCCAGGTGCCTCGGGCGTC TTCCCCCCACGTGTGAGTGGTCATGAAAGGCCACTTGTCAAAGCCCACCTTGGAGTCGTC ATCCCTTGGACGCCGGCTCATCAAAATGGACTTGGTGCCCATAGGGGAAGTCATGTTGAT GTTCAAGTCTCCTCTTCTGGTTGCGTTGACCGTGATGACAGCCTGGACATGCTCCAGGTA GCGGACAAAATTTTCCTTCCCCTCACAGGCGTCNGTTGTGAGTGTCAGCACCAACTTGCC AGTGGATGGTATTTTCTCAAGGTCCTGCACGGAGCCTCCCCACAGTGGAATCTCTCATGC ACGTTTTCCAGTCTTTAGCATTTTCACATGGCACCTGCTCAAGGACCCGTACCAAAGAGT GATTAATTTCAGGCGACCCCATGGCCGCCCTGATGACCTCGTCGGAAACTGGTCCGTTGN AGTAAGCACATAGAGCTGATGTCCGCAGTCAAACCAGT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002594 |
| Insert Size | 2460 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002594.2, NP_002585.2 |
| RefSeq Size | 4745 bp |
| RefSeq ORF | 1917 bp |
| Locus ID | 5126 |
| UniProt ID | P16519 |
| Domains | Peptidase_S8, P |
| Protein Families | Druggable Genome, Protease, Secreted Protein |
| Gene Summary | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC222498 | PCSK2 (Myc-DDK-tagged)-Human proprotein convertase subtilisin/kexin type 2 (PCSK2), transcript variant 1 |
CNY 4,752.00 |
|
| RC222498L1 | Lenti ORF clone of Human proprotein convertase subtilisin/kexin type 2 (PCSK2), transcript variant 1, Myc-DDK-tagged |
CNY 7,152.00 |
|
| RC222498L2 | Lenti ORF clone of Human proprotein convertase subtilisin/kexin type 2 (PCSK2), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC222498L3 | Lenti ORF clone of Human proprotein convertase subtilisin/kexin type 2 (PCSK2), transcript variant 1, Myc-DDK-tagged |
CNY 7,152.00 |
|
| RC222498L4 | Lenti ORF clone of Human proprotein convertase subtilisin/kexin type 2 (PCSK2), transcript variant 1, mGFP tagged |
CNY 7,152.00 |
|
| RG222498 | PCSK2 (tGFP-tagged) - Human proprotein convertase subtilisin/kexin type 2 (PCSK2), transcript variant 1 |
CNY 6,352.00 |
其它Proprotein Convertase 2产品
