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MMP1 (NM_002421) Human Untagged Clone
CAT＃: SC118645
MMP1 (untagged)-Human matrix metallopeptidase 1 (interstitial collagenase) (MMP1), transcript variant 1
CNY 5,488.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CLG; CLGN |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118645 sequence for NM_002421 edited (data generated by NextGen Sequencing)
ATGCACAGCTTTCCTCCACTGCTGCTGCTGCTGTTCTGGGGTGTGGTGTCTCACAGCTTC CCAGCGACTCTAGAAACACAAGAGCAAGATGTGGACTTAGTCCAGAAATACCTGGAAAAA TACTACAACCTGAAGAATGATGGGAGGCAAGTTGAAAAGCGGAGAAATAGTGGCCCAGTG GTTGAAAAATTGAAGCAAATGCAGGAATTCTTTGGGCTGAAAGTGACTGGGAAACCAGAT GCTGAAACCCTGAAGGTGATGAAGCAGCCCAGATGTGGAGTGCCTGATGTGGCTCAGTTT GTCCTCACTGAGGGGAACCCTCGCTGGGAGCAAACACATCTGACCTACAGGATTGAAAAT TACACGCCAGATTTGCCAAGAGCAGATGTGGACCATGCCATTGAGAAAGCCTTCCAACTC TGGAGTAATGTCACACCTCTGACATTCACCAAGGTCTCTGAGGGTCAAGCAGACATCATG ATATCTTTTGTCAGGGGAGATCATCGGGACAACTCTCCTTTTGATGGACCTGGAGGAAAT CTTGCTCATGCTTTTCAACCAGGCCCAGGTATTGGAGGGGATGCTCATTTTGATGAAGAT GAAAGGTGGACCAACAATTTCAGAGAGTACAACTTACATCGTGTTGCGGCTCATGAACTC GGCCATTCTCTTGGACTCTCCCATTCTACTGATATCGGGGCTTTGATGTACCCTAGCTAC ACCTTCAGTGGTGATGTTCAGCTAGCTCAGGATGACATTGATGGCATCCAAGCCATATAT GGACGTTCCCAAAATCCTGTCCAGCCCATCGGCCCACAAACCCCAAAAGCGTGTGACAGT AAGCTAACCTTTGATGCTATAACTACGATTCGGGGAGAAGTGATGTTCTTTAAAGACAGA TTCTACATGCGCACAAATCCCTTCTACCCGGAAGTTGAGCTCAATTTCATTTCTGTTTTC TGGCCACAACTGCCAAATGGGCTTGAAGCTGCTTACGAATTTGCCGACAGAGATGAAGTC CGGTTTTTCAAAGGGAATAAGTACTGGGCTGTTCAGGGACAGAATGTGCTACACGGATAC CCCAAGGACATCTACAGCTCCTTTGGCTTCCCTAGAACTGTGAAGCATATCGATGCTGCT CTTTCTGAGGAAAACACTGGAAAAACCTACTTCTTTGTTGCTAACAAATACTGGAGGTAT GATGAATATAAACGATCTATGGATCCAGGTTATCCCAAAATGATAGCACATGACTTTCCT GGAATTGGCCACAAAGTTGATGCAGTTTTCATGAAAGATGGATTTTTCTATTTCTTTCAT GGAACAAGACAATACAAATTTGATCCTAAAACGAAGAGAATTTTGACTCTCCAGAAAGCT AATAGCTGGTTCAACTGCAGGAAAAATTGA Clone variation with respect to NM_002421.3 648 a=>g >OriGene 5' read for NM_002421 unedited
CTATCACCCGCCCGTTGCCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAG CAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGC GAATTCGGCACGAGGCAAGAGGCTGGGAAGCCATCACTTACCTTGCACTGAGAAAGAAGA CAAAGGCCAGTATGCACAGCTTTCCTCCACTGCTGCTGCTGCTGTTCTGGGGTGTGGTGT CTCACAGCTTCCCAGCGACTCTAGAAACACAAGAGCAAGATGTGGACTTAGTCCAGAAAT ACCTGGAAAAATACTACAACCTGAAGAATGATGGGAGGCAAGTTGAAAAGCGGAGAAATA GTGGCCCAGTGGTTGAAAAATTGAAGCAAATGCAGGAATTCTTTGGGCTGAAAGTGACTG GGAAACCAGATGCTGAAACCCTGAAGGTGATGAAGCAGCCCAGATGTGGAGTGCCTGATG TGGCTCAGTTTGTCCTCACTGAGGGGAACCCTCGCTGGGAGCAAACACATCTGACCTACA GGATTGAAAATTACACGCCAGATTTGCCAAGAGCAGATGTGGACCATGCCATTGAGAAAG CCTTCCAACTCTGGAGTAATGTCACACCTCTGACATTCACCAAGGTCTCTGAGGGTCAAG CAGACATCATGATATCTTTTGTCAGGGGAGATCATCGGGACAACTCTCCTTTTGATGGAC CTGGAGGAAATCTTGCTCATGCTTTTCAACCAGGCCCAGGTATTGGAGGGGATGCTCATT TTGATGAAGATGAAAGGTGGACCAACAATTTCAGAGAGTACAACTTACATCGTGTTGCGG CTCATGAACTCGGCCATTCTCTGGNACTCTCCNATTCTACTGATATCGGGGCTTTGATGT ACCCTAGCTACACCTT >OriGene 3' read for NM_002421 unedited
TAACCTTAGGGANCGTCGGCCGCATCCTANAGTCGAGTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTTTAAAACAGTAAAAACAAGGGTGACTTTATTCCAAA CATAAAACACTTATTTTGGGTTAAAAAAGTTATCCCTTGCCTATCCAGGGGGACACCAGT GACTGCACATGTGTTCTTGAGCTGCTTTTCCTCCGGCAAAAACTCATGTCTCCTGTCTCT TTCTGTCTTGAAAGGATATGTTTGTCACTGAAGCTGCTCTCTGGGATCAACGTCAGAGTT GCATACTCTAAAAAAAATCTTTGCAACTCTGGCCTATTTGAATCCATAAGCCACAAACTT GACTTTTTGTACCCACCATTTGGGGAACTAAATTATATCAGTACAAAAAGGGCTACATTC TAAATAGTAAAAAAATATGCAAACTGAGGTATAAATAAAATTATATTCTGGGTATCAGGG ACTCTAGAGGTTAAAAATGACTGAGAAAATAGACAGTTCTTCAAGAAAACACCTCCTTTG GACTCACACCATGTGTTTTCCATTCAAATTAGTAATGTTCAATTTTTCCTGCAGTTGAAC CAGCTATTAGCTTTCTGGAGAGTCAAAATTCTCTTCGTTTTAGGATCAAATTTGTATTGT CTTGTTCCATGAAAGAATAGAAAATCCATCTTTCATGAAAACTGCATCAACTTTGTGGCC AATTCCAGGAAAGTCATGTGCTATCATTTTGGGATAACCCTGGATCCATAGATCGGTTAT ATTCATCATACCCCCAGTATTTGTTAGCAACAAAGAAGTAGGTTTTTCCAGTGTTTTCCT CAGAAGAGCAGCATCCATTTGCCTCACAGTTCTAGGGAACCAAAAGGAGCTGTAAATGTC CTTGGGGAATCC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002421 |
| Insert Size | 2000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002421.2, NP_002412.1 |
| RefSeq Size | 1973 bp |
| RefSeq ORF | 1410 bp |
| Locus ID | 4312 |
| UniProt ID | P03956 |
| Domains | hemopexin, Peptidase_M10, ZnMc |
| Protein Families | Druggable Genome, Protease, Secreted Protein |
| Protein Pathways | Bladder cancer, Pathways in cancer, PPAR signaling pathway |
| Gene Summary | This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Matrix Metalloprotease-1a Promotes Tumorigenesis and Metastasis
,Caitlin J. Foley, Chi Luo, Katie O'Callaghan, Philip W. Hinds, Lidija Covic, and Athan Kuliopulos,
J. Biol. Chem., Jul 2012; 287: 24330 - 24338.
[MMP1]
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Matrix metalloproteinase-1 promotes prostate tumor growth and metastasis
,Sai Murali Krishna Pulukuri, Jasti S. Rao,
Int J Oncol. 2008 April; 32(4): 757–765.
[MMP1]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC202460 | MMP1 (Myc-DDK-tagged)-Human matrix metallopeptidase 1 (interstitial collagenase) (MMP1), transcript variant 1 |
CNY 5,488.00 |
|
| RC202460L1 | Lenti ORF clone of Human matrix metallopeptidase 1 (interstitial collagenase) (MMP1), transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC202460L2 | Lenti ORF clone of Human matrix metallopeptidase 1 (interstitial collagenase) (MMP1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
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| RC202460L3 | Lenti ORF clone of Human matrix metallopeptidase 1 (interstitial collagenase) (MMP1), transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC202460L4 | Lenti ORF clone of Human matrix metallopeptidase 1 (interstitial collagenase) (MMP1), transcript variant 1, mGFP tagged |
CNY 7,888.00 |
|
| RG202460 | MMP1 (tGFP-tagged) - Human matrix metallopeptidase 1 (interstitial collagenase) (MMP1), transcript variant 1 |
CNY 7,088.00 |
