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IRF1 (NM_002198) Human Untagged Clone
CAT＃: SC118744
IRF1 (untagged)-Human interferon regulatory factor 1 (IRF1)
CNY 3,600.00
| Cited in 6 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | IRF-1; MAR |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_002198, the custom clone sequence may differ by one or more nucleotides
ATGCCCATCACTCGGATGCGCATGAGACCCTGGCTAGAGATGCAGATTAATTCCAACCAAATCCCGGGGC TCATCTGGATTAATAAAGAGGAGATGATCTTCCAGATCCCATGGAAGCATGCTGCCAAGCATGGCTGGGA CATCAACAAGGATGCCTGTTTGTTCCGGAGCTGGGCCATTCACACAGGCCGATACAAAGCAGGGGAAAAG GAGCCAGATCCCAAGACGTGGAAGGCCAACTTTCGCTGTGCCATGAACTCCCTGCCAGATATCGAGGAGG TGAAAGACCAGAGCAGGAACAAGGGCAGCTCAGCTGTGCGAGTGTACCGGATGCTTCCACCTCTCACCAA GAACCAGAGAAAAGAAAGAAAGTCGAAGTCCAGCCGAGATGCTAAGAGCAAGGCCAAGAGGAAGTCATGT GGGGATTCCAGCCCTGATACCTTCTCTGATGGACTCAGCAGCTCCACTCTGCCTGATGACCACAGCAGCT ACACAGTTCCAGGCTACATGCAGGACTTGGAGGTGGAGCAGGCCCTGACTCCAGCACTGTCGCCATGTGC TGTCAGCAGCACTCTCCCCGACTGGCACATCCCAGTGGAAGTTGTGCCGGACAGCACCAGTGATCTGTAC AACTTCCAGGTGTCACCCATGCCCTCCACCTCTGAAGCTACAACAGATGAGGATGAGGAAGGGAAATTAC CTGAGGACATCATGAAGCTCTTGGAGCAGTCGGAGTGGCAGCCAACAAACGTGGATGGGAAGGGGTACCT ACTCAATGAACCTGGAGTCCAGCCCACCTCTGTCTATGGAGACTTTAGCTGTAAGGAGGAGCCAGAAATT GACAGCCCAGGGGGGGATATTGGGCTGAGTCTACAGCGTGTCTTCACAGATCTGAAGAACATGGATGCCA CCTGGCTGGACAGCCTGCTGACCCCAGTCCGGTTGCCCTCCATCCAGGCCATTCCCTGTGCACCGTAG >OriGene 5' read for NM_002198 unedited
TTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCTTAGTCGAGGCA AGACGTGCGCCCGAGCCCCGCCGAACCGAGGCCACCCGGAGCCGTGCCCAGTCCACGCCG GCCGTGCCCGGCGGCCTTAAGAACCCGGCAACCTCTGCCTTCTTCCCTCTTCCACTCGGA GTCGCGCTTCGCGCGCCCTCACTGCAGCCCCTGCGTCGCCGGGACCCTCGCGCGCGACCG CCGAATCGCTCCTGCAGCAGAGCCAACATGCCCATCACTCGGATGCGCATGAGACCCTGG CTAGAGATGCAGATTAATTCCAACCAAATCCCGGGGCTCATCTGGATTAATAAAGAGGAG ATGATCTTCCAGATCCCATGGAAGCATGCTGCCAAGCATGGCTGGGACATCAACAAGGAT GCCTGTTTGTTCCGGAGCTGGGCCATTCACACAGGCCGATACAAAGCAGGGGAAAAGGAG CCAGATCCCAAGACGTGGAAGGCCAACTTTCGCTGTGCCATGAACTCCCTGCCAGATATC GAGGAGGTGAAAGACCAGAGCAGGAACAAGGGCAGCTCAGCTGTGCGAGTGTACCGGATG CTTCCACCTCTCACCAAGAACCAGAGAAAAGAAAGAAGGTTCGAAGTCCAGCCGAGATGC TAAGAGCAAGGCCAGNNAGGAAGTCATGTGGGGGGATTCCAGCCCTGATACCTTCTCTGA TGGACTCAGCAGCTCCACTCTGCCTGATGACCACAGCACCTACACAGTTCCAGGCTCATG CAGACTTTGGGAGGGGGGAACAGGCCCTGACTCACCTGGNNNCCCCGGGTGCTGTCACAG CACTCTCCCCGACTGCACATCCAAANGGGAAAGGTGGCGCGGACAGACCCCGGGATCTGT CAACT >OriGene 3' read for NM_002198 unedited
GGCACGCAATCTAAAGTCGAGTTTTTTTTTTTTTTTTTTTTTTGGGGCCCGGGCTGGAGT GCAATGGCATGTTCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCTTG CCTCAGCCTCCTGAGTAGCTGGGATTACAAGCACCCGCAACCACGCCCAGCTAATTTTTG CATTTTTAGTAAAAATGGAGTTTCACCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATC CACCCATCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCGCCTGTCCGA AAGGATTTTATAACAGATGCATGTCCCTGTTCACCCCAAAGTCAAGTTCAAGCGGGATGC CAATAATAAGTCCATCAGTGTTTCCATAAAAAGTAAAATCATCTACAAGGCAAATTTCTC TCTAAAAAGGCCACACCCTTATAAACAATTTACTTTTTTATAAAAAGACAAATGTACATA TTTACACACGTCCTTATGTGTTCACACATGACTTAAAGGCTAAATGACATTTACAATTTT AAGTTATACCAAGGCGCCTCACACTTACCTCCCTGGGCCCTGTTGAAGGCCTGCTGGGGC TTGAAGGGGCGGTGGGCCCCTAGCCACGCCCTGTTTAAATAAACGCAAAGGCCAAAATCT CGGTGGAAAAGTTAATGCTCACCCCTGATCAAAATGTGGCTTGATCCCACCAAAAATTCC AATTGTTTTTCCCACTCCCCCCCCCATCAGGAGCCCAGGACACCCCTCTGAGGCTGAGGA ACCCTGCCCAGAAGAACCCCTTTTCCTCAATATACCGCGTTTGGAACACACCCCCGGCTA TTTTAAATGGGGTTATTTTTTGCAACCAAATATATATCGCCATTTTTTTACCGCATACCC ACCTGGATCGTGCCTTACACCCTGCGCCCCCGCCCGATCCCAGTCACATCCTTTTCNTTA TACCCCTTCACACCGGAC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002198 |
| Insert Size | 2600 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002198.1, NP_002189.1 |
| RefSeq Size | 2035 bp |
| RefSeq ORF | 978 bp |
| Locus ID | 3659 |
| UniProt ID | P10914 |
| Domains | IRF |
| Protein Families | Druggable Genome, Transcription Factors |
| Gene Summary | The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017] |
Citations (6)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Interferon regulatory factor 1 (IRF1) inhibits lung endothelial regeneration following inflammation-induced acute lung injury
,null,
Clinical Science (London, England : 1979)
,PubMed ID 36857175
[IRF1]
|
|
iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice
,Du, Q;Luo, J;Yang, MQ;Liu, Q;Heres, C;Yan, YH;Stolz, D;Geller, DA;,
Mol. Med.
,PubMed ID 32517688
[IRF1]
|
|
Immune Mediators Regulate CFTR Expression through a Bifunctional Airway-Selective Enhancer
,Zhaolin Zhang, Shih-Hsing Leir, and Ann Harris,
Mol. Cell. Biol., Aug 2013; 33: 2843 - 2853.
,PubMed ID 23689137
[IRF1]
|
|
Dysregulation of interferon regulatory factors impairs the expression of immunostimulatory molecules in hepatitis C virus genotype 1-infected hepatocytes
,Esther Larrea, Jose-I Riezu-Boj, Rafael Aldabe, Laura Guembe, Itziar Echeverria, Anangi Balasiddaiah, Pablo Gastaminza, María Pilar Civeira, Pablo Sarobe, and Jesus Prieto,
Gut, Jun 2013; 10.1136/gutjnl-2012-304377.
,PubMed ID 23787026
[IRF1]
|
|
IRF-1 and miRNA126 Modulate VCAM-1 Expression in Response to a High-Fat Meal
,Chongxiu Sun, Kenan Alkhoury, Ying I. Wang, Greg A. Foster, Christopher E. Radecke, Kayan Tam, Christina M. Edwards, Marc T. Facciotti, Ehrin J. Armstrong, Anne A. Knowlton, John W. Newman, Anthony G. Passerini, and Scott I. Simon,
Circ. Res., Sep 2012; 111: 1054 - 1064.
[IRF1]
|
|
Virus-Activated Interferon Regulatory Factor 7 Upregulates Expression of the Interferon-Regulated BST2 Gene Independently of Interferon Signaling
,Mariana G. Bego, Johanne Mercier, and Éric A. Cohen,
J. Virol., Apr 2012; 86: 3513 - 3527.
[IRF1]
|
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Resources
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