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IFIT3 (NM_001549) Human Untagged Clone
CAT＃: SC119171
IFIT3 (untagged)-Human interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 1
CNY 5,488.00
Product images
CNY 1,999.00
CNY 2,700.00
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CIG-49; cig41; GARG-49; IFI60; IFIT4; IRG2; ISG60; P60; RIG-G |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC119171 sequence for NM_001549 edited (data generated by NextGen Sequencing)
ATGAGTGAGGTCACCAAGAATTCCCTGGAGAAAATCCTTCCACAGCTGAAATGCCATTTC ACCTGGAACTTATTCAAGGAAGACAGTGTCTCAAGGGATCTAGAAGATAGAGTGTGTAAC CAGATTGAATTTTTAAACACTGAGTTCAAAGCTACAATGTACAACTTGTTGGCCTACATA AAACACCTAGATGGTAACAACGAGGCAGCCCTGGAATGCTTACGGCAAGCTGAAGAGTTA ATCCAGCAAGAACATGCTGACCAAGCAGAAATCAGAAGTCTAGTCACTTGGGGAAACTAC GCCTGGGTCTACTATCACTTGGGCAGACTCTCAGATGCTCAGATTTATGTAGATAAGGTG AAACAAACCTGCAAGAAATTTTCAAATCCATACAGTATTGAGTATTCTGAACTTGACTGT GAGGAAGGGTGGACACAACTGAAGTGTGGAAGAAATGAAAGGGCGAAGGTGTGTTTTGAG AAGGCTCTGGAAGAAAAGCCCAACAACCCAGAATTCTCCTCTGGACTGGCAATTGCGATG TACCATCTGGATAATCACCCAGAGAAACAGTTCTCTACTGATGTTTTGAAGCAGGCCATT GAGCTGAGTCCTGATAACCAATACGTCAAGGTTCTCTTGGGCCTGAAACTGCAGAAGATG AATAAAGAAGCTGAAGGAGAGCAGTTTGTTGAAGAAGCCTTGGAAAAGTCTCCTTGCCAA ACAGATGTCCTCCGCAGTGCAGCCAAATTTTACAGAAGAAAAGGTGACCTAGACAAAGCT ATTGAACTGTTTCAACGGGTGTTGGAATCCACACCAAACAATGGCTACCTCTATCACCAG ATTGGGTGCTGCTACAAGGCAAAAGTAAGACAAATGCAGAATACAGGAGAATCTGAAGCT AGTGGAAATAAAGAGATGATTGAAGCACTAAAGCAATATGCTATGGACTATTCGAATAAA GCTCTTGAGAAGGGACTGAATCCTCTGAATGCATACTCCGATCTCGCTGAGTTCCTGGAG ACGGAATGTTATCAGACACCATTCAATAAGGAAGTCCCTGATGCTGAAAAGCAACAATCC CATCAGCGCTACTGCAACCTTCAGAAATATAATGGGAAGTCTGAAGACACTGCTGTGCAA CATGGTTTAGAGGGTTTGTCCATAAGCAAAAAATCAACTGACAAGGAAGAGATCAAAGAC CAACCACAGAATGTATCTGAAAATCTGCTTCCACAAAATGCACCAAATTATTGGTATCTT CAAGGATTAATTCATAAGCAGAATGGAGATCTGCTGCAAGCAGCCAAATGTTATGAGAAG GAACTGGGCCGCCTGCTAAGGGATGCCCCTTCAGGCATAGGCAGTATTTTCCTGTCAGCA TCTGAGCTTGAGGATGGTAGTGAGGAAATGGGCCAGGGCGCAGTCAGCTCCAGTCCCAGA GAGCTCCTCTCTAACTCAGAGCAACTGAACTGA Clone variation with respect to NM_001549.4 >OriGene 5' read for NM_001549 unedited
NGGAATTTGTATACGACTCACTTAGGGCGGCCGCGNATTCGGCACGAGGGCTTTCTGAAA AACAAATCAGCCTGGTCACCAGCTTTTCGGAACAGCAGAGACACAGAGGGCAGTCATGAG TGAGGTCACCAAGAATTCCCTGGAGAAAATCCTTCCACAGCTGAAATGCCATTTCACCTG GAACTTATTCAAGGAAGACAGTGTCTCAAGGGATCTAGAAGATAGAGTGTGTAACCAGAT TGAATTTTTAAACACTGAGTTCAAAGCTACAATGTACAACTTGTTGGCCTACATAAAACA CCTAGATGGTAACAACGAGGCAGCCCTGGAATGCTTACGGCAAGCTGAAGAGTTAATCCA GCAAGAACATGCTGACCAAGCAGAAATCAGAAGTCTAGTCACTTGGGGAAACTACGCCTG GGTCTACTATCACTTGGGCAGACTCTCAGATGCTCAGATTTATGTAGATAAGGTGAAACA AACCTGCAAGAAATTTTCAAATCCATACAGTATTGAGTATTCTGAACTTGACTGTGAGGA AGGGTGGACACAACTGAAGTGTGGAAGAAATGAAAGGGCGAAGGTGTGTTTTGAGAAGGC TCTGGAAGAAAAGCCCAACAACCCAGAATTCTCCTCTGGACTGGCAATTGCGATGTACCA TCTGGATAATCACCCAGAGAAACAGTTCTCTACTGATGTTTTGAAGCAGGCCATTGAGCT GAGTCCTGATAACCAATACGTCAAGGTTCTCTTGGGCCTGAAACTGCAGAAGATGAATAA AGAAGCTGAAGGAGAGCAGTTTGTTGAAGAAGCCTTTGGAAAGTCTNCTTGNCCAACAGA TGTCCTCCGCAGTGCAGCCCAAATTTACAGAAAANAAGGTGACCTAGACAAAGCTATTGA ACTGGTTCAACGGGTGNTGGAATNCCACCAAACATGG >OriGene 3' read for NM_001549 unedited
TCTTGGCCGCGGCCGCATCTAAGTCGAGTTTTTTTTTTTTTTTTTTGAGAGGAGTCTTGC TCTGTTGCCCAGGCTGGAGTGCAGGGGCGCAATCTTGGCTCACTGCAACCTCTTCCTTCC AGGTTCACGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGCCAGCCA CCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGATTTCACTGTGTTAGCCAGG ATGGTCTCAAACTCCAGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATT ACAGGCATGAGCCACTGCGCCCGGCCAAAAAACAACTCTTTAAAAATGTACCTTAGAGCA ACATGCAAAGCTTCCCTGCTCAGCAATCCCAGGTTGGGGCCCCCTGTCTTCCTATCGTCC TACCCGTCACAACCACCACCTGCAGGCTTCTGATGCTCTGTTTTCCTCCTCTGTCTCAGT TCAGTCGCTCTGAGTTAGAGAGGAGCTCTCTGGGACTGGAGCTGACTGCGCCCTGTCCCA TTCTCTCACTACCATCCTAAAGCTCAGATGCTGACAGGAAAATACTGCCTATGCCTGACG GGGCTCCCTTATCAGGCGGCCCAGCCCCTTCCCATAACATTGGGCTGGCTGCCACAGATC TCCATTCTGCTTATGAATTAATCCCTGAAAATACCAACAATTTGGGGCATTTCGTGGAAC CAAATTTTTAAATACCTCCTGGGCGGTCGCGCTTCGACCTCTTGCTTGCCACTGGAACTT TTGCCTTATGGCCACACCCTCTTAACACTGTTGGCCAACCGCGGCCTGCAAATTCCCCAT TTATTCCCCACGGTGCACCACCGCTCAGCGATTCCCGCTTTCCCCCACAGGGCTCCCCCT ATGGAGGGGCGCGCAAACTCGCCGCGAGGAACTCCGGACACGCCGTTCCGTTCGAGGTAT TCATCGCCTCACAAACT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001549 |
| Insert Size | 2100 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001549.2, NP_001540.2 |
| RefSeq Size | 1977 bp |
| RefSeq ORF | 1473 bp |
| Locus ID | 3437 |
| UniProt ID | O14879 |
| Domains | TPR |
| Gene Summary | IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 2 both encode isoform a, using different start codons but encoding identical proteins. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200610 | IFIT3 (Myc-DDK-tagged)-Human interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 1 |
CNY 5,488.00 |
|
| RC200610L1 | Lenti ORF clone of Human interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC200610L2 | Lenti ORF clone of Human interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC200610L3 | Lenti ORF clone of Human interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC200610L4 | Lenti ORF clone of Human interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG200610 | IFIT3 (tGFP-tagged) - Human interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 1 |
CNY 7,088.00 |
