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XIAP (NM_001167) Human Untagged Clone
CAT＃: SC119404
XIAP (untagged)-Human X-linked inhibitor of apoptosis (XIAP), transcript variant 1
CNY 3,656.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1; MIHA; XLP2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC119404 sequence for NM_001167 edited (data generated by NextGen Sequencing)
ATGACTTTTAACAGTTTTGAAGGATCTAAAACTTGTGTACCTGCAGACATCAATAAGGAA GAAGAATTTGTAGAAGAGTTTAATAGATTAAAAACTTTTGCTAATTTTCCAAGTGGTAGT CCTGTTTCAGCATCAACACTGGCACGAGCAGGGTTTCTTTATACTGGTGAAGGAGATACC GTGCGGTGCTTTAGTTGTCATGCAGCTGTAGATAGATGGCAATATGGAGACTCAGCAGTT GGAAGACACAGGAAAGTATCCCCAAATTGCAGATTTATCAACGGCTTTTATCTTGAAAAT AGTGCCACGCAGTCTACAAATTCTGGTATCCAGAATGGTCAGTACAAAGTTGAAAACTAT CTGGGAAGCAGAGATCATTTTGCCTTAGACAGGCCATCTGAGACACATGCAGACTATCTT TTGAGAACTGGGCAGGTTGTAGATATATCAGACACCATATACCCGAGGAACCCTGCCATG TATAGTGAAGAAGCTAGATTAAAGTCCTTTCAGAACTGGCCAGACTATGCTCACCTAACC CCAAGAGAGTTAGCAAGTGCTGGACTCTACTACACAGGTATTGGTGACCAAGTGCAGTGC TTTTGTTGTGGTGGAAAACTGAAAAATTGGGAACCTTGTGATCGTGCCTGGTCAGAACAC AGGCGACACTTTCCTAATTGCTTCTTTGTTTTGGGCCGGAATCTTAATATTCGAAGTGAA TCTGATGCTGTGAGTTCTGATAGGAATTTCCCAAATTCAACAAATCTTCCAAGAAATCCA TCCATGGCAGATTATGAAGCACGGATCTTTACTTTTGGGACATGGATATACTCAGTTAAC AAGGAGCAGCTTGCAAGAGCTGGATTTTATGCTTTAGGTGAAGGTGATAAAGTAAAGTGC TTTCACTGTGGAGGAGGGCTAACTGATTGGAAGCCCAGTGAAGACCCTTGGGAACAACAT GCTAAATGGTATCCAGGGTGCAAATATCTGTTAGAACAGAAGGGACAAGAATATATAAAC AATATTCATTTAACTCATTCACTTGAGGAGTGTCTGGTAAGAACTACTGAGAAAACACCA TCACTAACTAGAAGAATTGATGATACCATCTTCCAAAATCCTATGGTACAAGAAGCTATA CGAATGGGGTTCAGTTTCAAGGACATTAAGAAAATAATGGAGGAAAAAATTCAGATATCT GGGAGCAACTATAAATCACTTGAGGTTCTGGTTGCAGATCTAGTGAATGCTCAGAAAGAC AGTATGCAAGATGAGTCAAGTCAGACTTCATTACAGAAAGAGATTAGTACTGAAGAGCAG CTAAGGCGCCTGCAAGAGGAGAAGCTTTGCAAAATCTGTATGGATAGAAATATTGCTATC GTTTTTGTTCCTTGTGGACATCTAGTCACTTGTAAACAATGTGCTGAAGCAGTTGACAAG TGTCCCATGTGCTACACAGTCATTACTTTCAAGCAAAAAATTTTTATGTCTTAA Clone variation with respect to NM_001167.3 >OriGene 5' read for NM_001167 unedited
GGTAGGATTTTGTAACACGATTTCACTATAGGGCGGCCGCGAATTCGCACGAGGCCAAGC CGTAGAGCGGAGTTGGCATTTCCAGATTGGGGCTCGGGCCGCGCCTCCTCCGGGACCCTC CCCTTGGACCGAGCCGATCGCCGCGGGGCAGTTCGGGCCGGCTGTCCTGGCGCGAAAAGG TGGACAAGTCCTATTTTCAAGAGAAGATGACTTTTAACAGTTTTGAAGGATCTAAAACTT GTGTACCTGCAGACATCAATAAGGAAGAAGAATTTGTAGAAGAGTTTAATAGATTAAAAA CTTTTGCTAATTTTCCAAGTGGTAGTCCTGTTTCAGCATCAACACTGGCACGAGCAGGGT TTCTTTATACTGGTGAAGGAGATACCGTGCGGTGCTTTAGTTGTCATGCAGCTGTAGATA GATGGCAATATGGAGACTCAGCAGTTGGAAGACACAGGAAAGTATCCCCAAATTGCAGAT TTATCAACGGCTTTTATCTTGAAAATAGTGCCACGCAGTCTACAAATTCTGGTATCCAGA ATGGTCAGTACAAAGTTGAAAACTATCTGGGAAGCAGAGATCATTTTGCCTTAGACAGGC CATCTGAGACACATGCAGACTATCTTTTGAGAACTGNGCAGGTTGTAGATATATCAGACA CCATATACCCGAGGAACCCTGCCATGTATAGTGAAGAAGCTAGATTAAAAGTCCTTTCAG AACTGCCCAGACTATGCTCACCTAACCCCAGAGAGTTAGCCAGTGCTGGACTCTACTACA CAGGTATTGGTGACCAAGTGCAGTGCTTTTTGTTGTGGTGGAAAACTGAAAAAATGGGAA CCTGTGATCGTGCCTTGGTCAGACACAAGCGACACTTNTCCTAATTGCTTCTTTGGTTGG GGCCNGNATTCTTATATTCGAATGAAATTGAGGCTGGGAGGTCTGATG >OriGene 3' read for NM_001167 unedited
CGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTAAGGATCTTGAGAGAACAT TTATTTCAGAAGTATCTACTACTATTACTAGCCAAGAAAACAAATGTAGGTAGAGGAAAG ACTTAACATTTTGTCCTATATACATCTTAATCATCCTAATGGTAAAAACTCACATGAAAC TTTAAGATACAAGATGATATGAGAATCTCAACATGGAAAGCTGTCACTATAACTACAAGC AGTGTACAAACATGCTTCTACTTTTACCTACATAAGCTGACAGATGTTTAAAATACTGAG TTAACAAAGATCTTTTAGTAAAGTGACTTAGGCAGGCTTAAACTAGCAAGGATTAAGGAT GAATCCTTACTAATTAATTGGAAGATCTGAGACATATTTTATATTTCATTTTACAAAATC AGAAATACTTATTTTGAAACAAGATAAGACATGGTCTACCTGTCAAAAAACTACCACTCA GAAATATTTTTCATCCACAAAGCAGGAAAAACATAAAATCATTTACATTTCACATTGGCA CCAAAAAGGTTAACTGCCCTGCCTTCTTGGATTAGAAAAACTAAAGCTGAGTGATAAGTA GTTTTGCAGGCGTTTGAACATGCCTAAGCCTTTAAATCAGCAAAATACTTTCTAAAAATT CTGATTACAAAAGTAATACATACTTATAAAAAATTCGAACAGAACAAAATGAAAAAAGTA GAAGGTGGAAAAGGGCCCCTATAAAACCCCTATGGNGCCCTTTCCCCCCAATTCCCNCCC TTCCCGGAAGAGAAACCACATTTTACAGNNTTGGTGTATATCTTTCCAAATCTTTTGNTC TATGCATATTAAAACATACATACTTTGATCTGGCTAGACTTACATAGTGNNTTGCCACTG CATTTACACTTAACATATCTTGACATCTTCATGTAGTACATGTGGCTCGATAGATCTATC ATAATACGCTTCAAAATGCAATACC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001167 |
| Insert Size | 3000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001167.2, NP_001158.2 |
| RefSeq Size | 8413 bp |
| RefSeq ORF | 1494 bp |
| Locus ID | 331 |
| UniProt ID | P98170 |
| Domains | BIR, RING |
| Protein Families | Druggable Genome |
| Protein Pathways | Apoptosis, Focal adhesion, NOD-like receptor signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis |
| Gene Summary | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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miR-CATCH Identifies Biologically Active miRNA Regulators of the Pro-Survival Gene XIAP, in Chinese Hamster Ovary Cells
,Griffith, A;Kelly, PS;Vencken, S;Lao, NT;Greene, CM;Clynes, M;Barron, N;,
Biotechnol J
,PubMed ID 28976632
[XIAP]
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AAV-Mediated Gene Transfer of Human X-Linked Inhibitor of Apoptosis Protects against Oxidative Cell Death in Human RPE Cells
,Haidong Shan, Dan Ji, Alun R. Barnard, Daniel M. Lipinski, Qisheng You, Edward J. Lee, Tengku Ain Kamalden, Xinghuai Sun, and Robert E. MacLaren,
Invest. Ophthalmol. Vis. Sci., Dec 2011; 52: 9591 - 9597.
[XIAP]
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Inhibition of Constitutive Activation of STAT3 by Curcurbitacin-I (JSI-124) Sensitized Human B-Leukemia Cells to Apoptosis
,Ganchimeg Ishdorj, James B. Johnston, and Spencer B. Gibson,
Mol. Cancer Ther., Dec 2010; 9: 3302 - 3314
[XIAP]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC207627 | XIAP (Myc-DDK-tagged)-Human X-linked inhibitor of apoptosis (XIAP), transcript variant 1 |
CNY 3,656.00 |
|
| RC207627L1 | Lenti ORF clone of Human X-linked inhibitor of apoptosis (XIAP), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC207627L2 | Lenti ORF clone of Human X-linked inhibitor of apoptosis (XIAP), transcript variant 1, mGFP tagged |
CNY 6,056.00 |
|
| RC207627L3 | Lenti ORF clone of Human X-linked inhibitor of apoptosis (XIAP), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC207627L4 | Lenti ORF clone of Human X-linked inhibitor of apoptosis (XIAP), transcript variant 1, mGFP tagged |
CNY 6,056.00 |
|
| RG207627 | XIAP (tGFP-tagged) - Human X-linked inhibitor of apoptosis (XIAP), transcript variant 1 |
CNY 5,256.00 |
