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NQO1 (NM_000903) Human Untagged Clone
CAT＃: SC119599
NQO1 (untagged)-Human NAD(P)H dehydrogenase, quinone 1 (NQO1), transcript variant 1
CNY 2,400.00
CNY 2,950.00
| Cited in 6 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | DHQU; DIA4; DTD; NMOR1; NMORI; QR1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000903 edited
GAATTCGGCACGAGGCCTCGTGCCGAATTCGGCACGAGGTTGCAGCCGGAGCCGCCCAGC TCACCGAGAGCCTAGTTCCGGCCAGGGTCGCCCCGGCAACCACGAGCCCAGCCAATCAGC GCCCCGGACTGCACCAGAGCCATGGTCGGCAGAAGAGCACTGATCGTACTGGCTCACTCA GAGAGGACGTCCTTCAACTATGCCATGAAGGAGGCTGCTGCAGCGGCTTTGAAGAAGAAA GGATGGGAGGTGGTGGAGTCGGACCTCTATGCCATGAACTTCAATCCCATCATTTCCAGA AAGGACATCACAGGTAAACTGAAGGACCCTGCGAACTTTCAGTATCCTGCCGAGTCTGTT CTGGCTTATAAAGAAGGCCATCTGAGCCCAGATATTGTGGCTGAACAAAAGAAGCTGGAA GCCGCAGACCTTGTGATATTCCAGTTCCCCCTGCAGTGGTTTGGAGTCCCTGCCATTCTG AAAGGCTGGTTTGAGCGAGTGTTCATAGGAGAGTTTGCTTACACTTACGCTGCCATGTAT GACAAAGGACCCTTCCGGAGTAAGAAGGCAGTGCTTTCCATCACCACTGGTGGCAGTGGC TCCATGTACTCTCTGCAAGGGATCCACGGGGACATGAATGTCATTCTCTGGCCAATTCAG AGTGGCATTCTGCATTTCTGTGGCTTCCAAGTCTTAGAACCTCAACTGACATATAGCATT GGGCACACTCCAGCAGACGCCCGAATTCAAATCCTGGAAGGATGGAAGAAACGCCTGGAG AATATTTGGGATGAGACACCACTGTATTTTGCTCCAAGCAGCCTCTTTGACCTAAACTTC CAGGCAGGATTCTTAATGAAAAAAGAGGTACAGGATGAGGAGAAAAACAAGAAATTTGGC CTTTCTGTGGGCCATCACTTGGGCAAGTCCATCCCAACTGACAACCAGATCAAAGCTAGA AAATGAGATTCCTTAGCCTGGATTTCCTTCTAACATGTTATCAAATCTGGGTATCTTTCC AGGCTTCCCTGACTTGCTTTAGTTTTTAAGATTTGTGTTTTTCTTTTTCCACAAGGAATA AATGAGAGGGAATCGACTGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA ACTCGAC >OriGene 5' read for NM_000903 unedited
ATCGGGATTTGTAACCGACTTATATAGGCGGCCGCGCAATTCGCACGAGGCCTCGTGCCG AATTCGGCACGAGGTTGCAGCCGGAGCCGCCCAGCTCACCGAGAGCCTAGTTCCGGCCAG GGTCGCCCCGGCAACCACGAGCCCAGCCAATCAGCGCCCCGGACTGCACCAGAGCCATGG TCGGCAGAAGAGCACTGATCGTACTGGCTCATTCAGAGAGGACGTCCTTCAACTATGCCA TGAAGGAGGCTGCTGCAGCGGCTTTGAAGAAGAAAGGATGGGAGGTGGTGGAGTCGGACC TCTATGCCATGAACTTCAATCCCATCATTTCCAGAAAGGACATCACAGGTAAACTGAAGG ACCCTGCGAACTTTCAGTATCCTGCCGAGTCTGTTCTGGCTTATAAAGAAGGCCATCTGA GCCCAGATATTGTGGCTGAACAAAAGAAGCTGGAAGCCGCAGACCTTGTGATATTCCAGT TCCCCCTGCAGTGGTTTGGAGTCCCTGCCATTCTGAAAGGCTGGTTTGAGCGAGTGTTCA TAGGAGAGTTTGCTTACACTTACGCTGCCATGTATGACAAAGGACCCTTCCGGAGTAAGA AGGCAGTGCTTTCCATCACCACTGGTGGCAGTGGCTCCATGTACTCTCTGCAAGGGATCC ACGGNGACATGAATGTCATTCTCTGGCCAATTCAGAGTGGCATTCTGCATTTCTGTGGCT TCCAAGTCTTAGAACCTCAACTGACATATAGCATTGGGCACACTCCAGCAGACGCCCGAA TTCAAATCCTGGNAGGGATGGAAGAACGCCTGGAGAATATTTGGGATGAGACACCACTGT ATTTTGCTCCNAGCAGCCTCTTTGACCTANACTTCCCAGNCAGGATTCTTAATGAAAAAA GAAGTACAGGATGC >OriGene 3' read for NM_000903 unedited
GGCCGCAATCTAGAGTCGAGNNNTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TAACAGGCGATTCCCTCTCATTTATTCCTTGGGGAAAAAAAAAAACACAAATCTTAAAAA CTAAAGCAAGTCAGGGAACCCTGGAAAGATACCCAAATTTGATAACATGTTAAAAGGAAA TCCAGGCTAAGGAATCTCATTTTCTAGCTTTGATCTGGTTGTCAGTTGGGATGGACTTGC CCAAGTGATGGCCCACAAAAAGGCCAAATTTCTTGTTTTTCTCCTCATCCTGTACCTTTT TTTTCATTAAAAATCCTGCCTGGAAGTTTAGGTCAAAAAGGCTGCTTGGAGCAAAATACA GGGGGGTCTCATCCCAAATATTCTCCAGGCGTTTCTTCCATCCTTCCAGGATTTGAATTC GGGCGTCTGCTGGAGTGTGCCCAATGCTATATGTCAGTGGAGGTTCTAAAACTTGGAAGC CACAGAAATGCAAAATGCCACTCTGAATTGGCCAAAAAATGACATTCATGTCCCCGTGGA TCCCTTGCAAAGAGTACATGGAGCCACTGCCACCAGTGGTGATGGAAAGCACTGCCTTCT TACTCCGGAAGGGTCCTTTGTCATACATGGCAGCGTAAGTGTAAGCAAACTCTCCTATGA ACACTCGCTCAAACCAGCCTTTCAGATGGCAGGGACTCCAAACCACTGCAGGGGGAACTG GAATTCACAAGGTCTGCGGCTTACAGCTTCTTTTGTTCACCCACAATATCTGGGCTCANA TGGCCTTCTTTTAAGCCAAACAGACTCGGCAGATACTTGAAGTCGCAGGGCCCTTAGTTA CCTGGATGNCCTTCCTGAAAGATGGGATTGAGTTATGCCTANAGGCCGACTCCCACCTTC ATCTTTTTTTAAAGCGCTGAGACCCTCTATGATTAATGAAGACGTCTTTTAGGAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000903 |
| Insert Size | 1120 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000903.2, NP_000894.1 |
| RefSeq Size | 2601 bp |
| RefSeq ORF | 825 bp |
| Locus ID | 1728 |
| UniProt ID | P15559 |
| Domains | Flavodoxin_2 |
| Protein Families | Druggable Genome |
| Gene Summary | This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). |
Citations (6)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma
,Zhou, HZ;Zeng, HQ;Yuan, D;Ren, JH;Cheng, ST;Yu, HB;Ren, F;Wang, Q;Qin, YP;Huang, AL;Chen, J;,
Cell Commun. Signal
,PubMed ID 31842909
[NQO1]
|
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NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein
,Li, WY;Zhou, HZ;Chen, Y;Cai, XF;Tang, H;Ren, JH;Wai Wong, VK;Kwan Law, BY;Chen, Y;Cheng, ST;Yu, HB;Cai, HY;Chen, WX;Tang, N;Zhang, WL;Tao, NN;Yang, QX;Ren, F;He, L;Jiang, H;Huang, AL;Chen, J;,
Cancer Lett.
,PubMed ID 30867140
[NQO1]
|
|
Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays
,Rezende, F;Prior, KK;Löwe, O;Wittig, I;Strecker, V;Moll, F;Helfinger, V;Schnütgenc, F;Kurrlec, N;Wempe, F;Walter, M;Zukunft, S;Luck, B;Fleming, I;Weissmann, N;Brandes, RP;Schröder, K;,
Free Radical Biology and Medicine
,PubMed ID 27863990
[NQO1]
|
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Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)-Mediated Inactivation of Reactive Quinoneimine Metabolites of Diclofenac and Mefenamic Acid
,Vredenburg, G;Elias, NS;Venkataraman, H;Hendriks, DF;Vermeulen, NP;Commandeur, JN;Vos, JC;,
Chem. Res. Toxicol., Feb 2014.
,PubMed ID 24552538
[NQO1]
|
|
Suppression of NAD(P)H-quinone oxidoreductase 1 enhanced the susceptibility of cholangiocarcinoma cells to chemotherapeutic agents
,Zeekpudsa, P;Kukongviriyapan, V;Senggunprai, L;Sripa, B;Prawan, A;,
J. Exp. Clin. Cancer Res., Jan 2014.
,PubMed ID 24460787
[NQO1]
|
|
NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells
,null,
The Journal of steroid biochemistry and molecular biology
,PubMed ID 19628038
[NQO1]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200620 | NQO1 (Myc-DDK-tagged)-Human NAD(P)H dehydrogenase, quinone 1 (NQO1), transcript variant 1 |
CNY 2,400.00 |
|
| RC200620L1 | Lenti ORF clone of Human NAD(P)H dehydrogenase, quinone 1 (NQO1), transcript variant 1, Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC200620L2 | Lenti ORF clone of Human NAD(P)H dehydrogenase, quinone 1 (NQO1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC200620L3 | Lenti ORF clone of Human NAD(P)H dehydrogenase, quinone 1 (NQO1), transcript variant 1, Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC200620L4 | Lenti ORF clone of Human NAD(P)H dehydrogenase, quinone 1 (NQO1), transcript variant 1, mGFP tagged |
CNY 4,800.00 |
|
| RG200620 | NQO1 (tGFP-tagged) - Human NAD(P)H dehydrogenase, quinone 1 (NQO1), transcript variant 1 |
CNY 4,000.00 |
