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ATP1A2 (NM_000702) Human Untagged Clone
CAT＃: SC119715
ATP1A2 (untagged)-Human ATPase, Na+/K+ transporting, alpha 2 polypeptide (ATP1A2)
CNY 10,664.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | FHM2; MHP2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC119715 sequence for NM_000702 edited (data generated by NextGen Sequencing)
ATGGGCCGTGGGGCTGGCCGTGAGTACTCACCTGCCGCCACCACGGCAGAGAATGGGGGC GGCAAGAAGAAACAGAAGGAGAAGGAACTGGATGAGCTGAAGAAGGAGGTGGCAATGGAT GACCACAAGCTGTCCTTGGATGAGCTGGGCCGCAAATACCAAGTGGACCTGTCCAAGGGC CTCACCAACCAGCGGGCTCAGGACGTTCTGGCTCGAGATGGGCCCAACGCCCTCACACCA CCTCCCACAACCCCTGAGTGGGTCAAGTTCTGCCGTCAGCTTTTCGGGGGGTTCTCCATC CTGCTGTGGATTGGGGCTATCCTCTGCTTCCTGGCCTACGGCATCCAGGCTGCCATGGAG GATGAACCATCCAACGACAATCTATATCTGGGTGTGGTGCTGGCAGCTGTGGTCATTGTC ACTGGCTGCTTCTCCTACTACCAGGAGGCCAAGAGCTCCAAGATCATGGATTCCTTCAAG AACATGGTACCTCAGCAAGCCCTTGTGATCCGGGAGGGAGAGAAGATGCAGATCAACGCA GAGGAAGTGGTGGTGGGAGACCTGGTGGAGGTGAAGGGTGGAGACCGCGTCCCTGCTGAC CTCCGGATCATCTCTTCTCATGGCTGTAAGGTGGATAACTCATCCTTAACAGGAGAGTCG GAGCCCCAGACCCGCTCCCCCGAGTTCACCCATGAGAACCCCCTGGAGACCCGCAATATC TGTTTCTTCTCCACCAACTGTGTTGAAGGCACTGCCAGGGGCATTGTGATTGCCACAGGA GACCGGACGGTGATGGGCCGCATAGCTACTCTCGCCTCAGGCCTGGAGGTTGGGCGGACA CCCATAGCAATGGAGATTGAACACTTCATCCAGCTGATCACAGGGGTCGCTGTATTCCTG GGGGTCTCCTTCTTCGTGCTCTCCCTCATCCTGGGCTACAGCTGGCTGGAGGCAGTCATC TTCCTCATCGGCATCATAGTGGCCAACGTGCCTGAGGGGCTTCTGGCCACTGTCACTGTG TGCCTGACCCTGACAGCCAAGCGCATGGCACGGAAGAACTGCCTGGTGAAGAACCTGGAG GCGGTGGAGACGCTGGGCTCCACGTCCACCATCTGCTCGGACAAGACGGGCACCCTCACC CAGAACCGCATGACCGTCGCCCACATGTGGTTCGACAACCAAATCCATGAGGCTGACACC ACCGAAGATCAGTCTGGGGCCACTTTTGACAAACGATCCCCTACGTGGACGGCCCTGTCT CGAATTGCTGGTCTCTGCAACCGCGCCGTCTTCAAGGCAGGACAGGAGAACATCTCCGTG TCTAAGCGGGACACAGCTGGTGATGCCTCTGAGTCAGCTCTGCTCAAGTGCATTGAGCTC TCCTGTGGCTCAGTGAGGAAAATGAGAGACAGAAACCCCAAGGTGGCAGAGATTCCTTTC AACTCTACCAACAAGTACCAGCTGTCTATCCACGAGCGAGAAGACAGCCCCCAGAGCCAC GTGCTGGTGATGAAGGGGGCCCCAGAGCGCATTCTGGACCGGTGCTCCACCATCCTGGTG CAGGGCAAGGAGATCCCGCTCGACAAGGAGATGCAAGATGCCTTTCAAAATGCCTACATG GAGCTGGGGGGACTTGGGGAGCGTGTGCTGGGATTCTGTCAACTGAATCTGCCATCTGGA AAGTTTCCTCGGGGCTTCAAATTCGACACGGATGAGCTGAACTTTCCCACGGAGAAGCTT TGCTTTGTGGGGCTCATGTCTATGATTGACCCTCCCCGGGCTGCTGTGCCAGATGCTGTG GGCAAGTGCCGAAGCGCAGGCATCAAGGTGATCATGGTAACCGGGGATCACCCTATCACA GCCAAGGCCATTGCCAAAGGCGTGGGCATCATATCAGAGGGTAACGAGACTGTGGAGGAC ATTGCAGCCCGGCTCAACATTCCCATGAGTCAAGTCAACCCCAGAGAAGCCAAGGCATGC GTGGTGCACGGCTCTGACCTGAAGGACATGACATCGGAGCAGCTCGATGAGATCCTCAAG AACCACACAGAGATCGTCTTTGCTCGAACGTCTCCCCAGCAGAAGCTCATCATTGTGGAG GGATGTCAGAGGCAGGGAGCCATTGTGGCCGTGACGGGTGACGGGGTGAACGACTCCCCT GCATTGAAGAAGGCTGACATTGGCATTGCCATGGGCATCTCTGGCTCTGACGTCTCTAAG CAGGCAGCCGACATGATCCTGCTGGATGACAACTTTGCCTCCATCGTCACGGGGGTGGAG GAGGGCCGCCTGATCTTTGACAACTTGAAGAAATCCATCGCCTACACCCTGACCAGCAAC ATCCCCGAGATCACCCCCTTCCTGCTGTTCATCATTGCCAACATCCCCCTACCTCTGGGC ACTGTGACCATCCTTTGCATTGACCTGGGCACAGATATGGTCCCTGCCATCTCCTTGGCC TATGAGGCAGCTGAGAGTGATATCATGAAGCGGCAGCCACGAAACTCCCAGACGGACAAG CTGGTGAATGAGAGGCTCATCAGCATGGCCTACGGACAGATCGGGATGATCCAGGCACTG GGTGGCTTCTTCACCTACTTTGTGATCCTGGCAGAGAACGGTTTCCTGCCATCACGGCTA CTGGGAATCCGCCTCGACTGGGATGACCGGACCATGAATGATCTGGAGGACAGCTATGGA CAGGAGTGGACCTATGAGCAGCGGAAGGTGGTGGAGTTCACGTGCCACACGGCATTCTTT GCCAGCATCGTGGTGGTGCAGTGGGCTGACCTCATCATCTGCAAGACCCGCCGCAACTCA GTCTTCCAGCAGGGCATGAAGAACAAGATCCTGATTTTTGGGCTCCTGGAGGAGACGGCG TTGGCTGCCTTTCTCTCTTACTGCCCAGGCATGGGTGTAGCCCTCCGCATGTACCCGCTC AAAGTCACCTGGTGGTTCTGCGCCTTCCCCTACAGCCTCCTCATCTTCATCTATGATGAG GTCCGAAAGCTCATCCTGCGGCGGTATCCTGGTGGCTGGGTGGAGAAGGAGACATACTAC TGA Clone variation with respect to NM_000702.3 >OriGene 5' read for NM_000702 unedited
GGCACATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCCGAGGTCTCCGACTGTC CCAGACGGGCTGGTGTGGGCTTGGGATCCTCCTGGTGACCTCTCCCGCTAAGGTCCCTCA GCCACTCTGCCCCAAGATGGGCCGTGGGGCTGGCCGTGAGTACTCACCTGCCGCCACCAC GGCAGAGAATGGGGGCGGCAAGAAGAAACAGAAGGAGAAGGAACTGGATGAGCTGAAGAA GGAGGTGGCAATGGATGACCACAAGCTGTCCTTGGATGAGCTGGGCCGCAAATACCAAGT GGACCTGTCCAAGGGCCTCACCAACCAGCGGGCTCAGGACGTTCTGGCTCGAGATGGGCC CAACGCCCTCACACCACCTCCCACAACCCCTGAGTGGGTCAAGTTCTGCCGTCAGCTTTT CGGGGGGTTCTCCATCCTGCTGTGGATTGGGGCTATCCTCTGCTTCCTGGCCTACGGCAT CCAGGCTGCCATGGAGGATGAACCATCCAACGACAATCTATATCTGGGTGTGGTGCTGGC AGCTGTGGTCATTGTCACTGGCTGCTTCTCCTACTACCAGGAGGCCAAGAGCTCCAAGAT CATGGATTCCTTCAAGAACATGGTACCTCAGCAAGCCCTTGTGATCCGGGAGGGAGAGAA GATGCAGATCAACGCATAGGAAGTGGTGGTGGGAGAACTGGTGGAGGTGAAGGGTGGAGA CCGCGTCCCTGCTGACCCCCGGATCACCTCTTTTATGGCTGTAAGGTGGAAACTCATCCT TACCAGAGAGTTCGACCCCCAGACCCGTCCCCCGAGTTACCCATGAGAACCCCTGGAGAC CCGGCATATCTGGTTTCTTCTCCCCCACTGTGTTGAAAGCCCTGCCCAGGCCTTTGGGAT TGC >OriGene 3' read for NM_000702 unedited
CCGCGGCCGCAATCTAAAGTCGAGTTTTTTTTTTTTTTTTTTGAGAGGAGTCTCACCCTT TCGCCCAGGCTGGAGTGTAATGGCACGATCTCAGCTCACTGCAACCTCTTCCTCACAGGT TCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGAGATTACAGGCGTGTGCCACCAT GACTGGCTAATTTTTTGTACTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTCG CCTCGAACTCCTGACCTCATGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAG GCATGAGCCACCGCACCCAGAAAAAGCAAATCTCTTAGTATTTTTCCTCTTGTCCAAAGG TTCTGACCATGTTCATGACCTAAGCTTGTCCCTGGAAGCATACATGTCCCTGGGAGACAG GAAGGTTCAGGGAACTTCTCCACCCTGATTCTAGCCAATGGCCAGCGAACTCCTTTTCCA GGGTTGGCTTGGCAGTGTCGGGGAATGATGCAGGTTCATCGGGATGGGCATGAAAAGAAA GGGAATGGAAGAGGCTGGGAAAGAACTTGTGGCCATCCCTTTCAGAACAGCATGGAGCTC TGANGACTTAGTATTACAGAAGGTGAAGTGTTATTAAGTACATGAGTGACATCCGGACCT TGTGGACTAAGAAGGACCCTACCAAAGGTCAGCGGGGAACTCTGTGCACACAAGGTGGCA TTTCTGGAGCCTCTGATTGCCTCTGGCCTGCTCTGCTGCACCCTGAGAGACTGAGTTTGT CTGCTGTGGGGGATCTAAAAGTGGACGATAGCTGGATCCCCACTCTATTGGAACTAGTCA AAGCCCGGCATGGCCCACCTACTTCTTTTGTGGTCCTCCTCCACCG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000702 |
| Insert Size | 5000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000702.2, NP_000693.1 |
| RefSeq Size | 5468 bp |
| RefSeq ORF | 3063 bp |
| Locus ID | 477 |
| UniProt ID | P50993 |
| Domains | E1-E2_ATPase, Cation_ATPase_N, Hydrolase, Cation_ATPase_C |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cardiac muscle contraction |
| Gene Summary | The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump
,Schneditz, G;Elias, JE;Pagano, E;Zaeem Cader, M;Saveljeva, S;Long, K;Mukhopadhyay, S;Arasteh, M;Lawley, TD;Dougan, G;Bassett, A;Karlsen, TH;Kaser, A;Kaneider, NC;,
Sci Signal
,PubMed ID 30600262
[ATP1A2]
|
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The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations
,J. Preben Morth, Hanne Poulsen, Mads S Toustrup-Jensen, Vivien Rodacker Schack, Jan Egebjerg, Jens Peter Andersen, Bente Vilsen, and Poul Nissen,
Phil Trans R Soc B, Jan 2009; 364: 217 - 227.
[ATP1A2]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208606 | ATP1A2 (Myc-DDK-tagged)-Human ATPase, Na+/K+ transporting, alpha 2 polypeptide (ATP1A2) |
CNY 10,656.00 |
|
| RC208606L1 | Lenti ORF clone of Human ATPase, Na+/K+ transporting, alpha 2 polypeptide (ATP1A2), Myc-DDK-tagged |
CNY 13,056.00 |
|
| RC208606L2 | Lenti ORF clone of Human ATPase, Na+/K+ transporting, alpha 2 polypeptide (ATP1A2), mGFP tagged |
CNY 7,600.00 |
|
| RC208606L3 | Lenti ORF clone of Human ATPase, Na+/K+ transporting, alpha 2 polypeptide (ATP1A2), Myc-DDK-tagged |
CNY 7,600.00 |
|
| RC208606L4 | Lenti ORF clone of Human ATPase, Na+/K+ transporting, alpha 2 polypeptide (ATP1A2), mGFP tagged |
CNY 7,600.00 |
|
| RG208606 | ATP1A2 (tGFP-tagged) - Human ATPase, Na+/K+ transporting, alpha 2 polypeptide (ATP1A2) |
CNY 12,256.00 |
