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SIRP alpha (SIRPA) (NM_080792) Human Untagged Clone
CAT＃: SC120326
SIRPA (untagged)-Human signal-regulatory protein alpha (SIRPA), transcript variant 3
CNY 3,760.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BIT; CD172A; MFR; MYD-1; P84; PTPNS1; SHPS1; SIRP |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_080792 edited
GAATTCGGCACGAGGCCCTGGCTTTATTTCTCGCGCGCTTGGGGTCTCTCCCAGTCTCCG TCTCTCCATTTCTCCTGGGGGGCGGGGAGGGGGGGTCTCCAAAAACCGCGGCGGCGGCGG CGGCCGCTCCAGGCGCCCGTTCCGGAGTCGGGGGGAGGCCCAGCCGGGAGGGGGGAAGGG GGGGAGCCTTAGTCATTTCCCCGCTCCAGCCTGCTCCCGCCCGAGCGCGCACTCACGGCC GCTCTCCCTCCTCGCTCCGCAGCCGCGGCCCATGGAGCCCGCCGGCCCGGCCCCCGGCCG CCTCGGGCCGCTGCTCTGCCTGCTGCTCGCCGCGTCCTGCGCCTGGTCAGGAGTGGCGGG TGAGGAGGAGCTGCAGGTGATTCAGCCTGACAAGTCCGTGTTGGTTGCAGCTGGAGAGAC AGCCACTCTGCGCTGCACTGCGACCTCTCTGATCCCTGTGGGGCCCATCCAGTGGTTCAG AGGAGCTGGACCAGGCCGGGAATTAATCTACAATCAAAAAGAAGGCCACTTCCCCCGGGT AACAACTGTTTCAGACCTCACAAAGAGAAACAACATGGACTTTTCCATCCGCATCGGTAA CATCACCCCAGCAGATGCCGGCACCTACTACTGTGTGAAGTTCCGGAAAGGGAGCCCCGA TGACGTGGAGTTTAAGTCTGGAGCAGGCACTGAGCTGTCTGTGCGCGCCAAACCCTCTGC CCCCGTGGTATCGGGCCCTGCGGCGAGGGCCACACCTCAGCACACAGTGAGCTTCACCTG CGAGTCCCACGGCTTCTCACCCAGAGACATCACCCTGAAATGGTTCAAAAATGGGAATGA GCTCTCAGACTTCCAGACCAACGTGGACCCCGTAGGAGAGAGCGTGTCCTACAGCATCCA CAGCACAGCCAAGGTGGTGCTGACCCGCGAGGACGTTCACTCTCAAGTCATCTGCGAGGT GGCCCACGTCACCTTGCAGGGGGACCCTCTTCGTGGGACTGCCAACTTGTCTGAGACCAT CCGAGTTCCACCCACCTTGGAGGTTACTCAACAGCCCGTGAGGGCAGAGAACCAGGTGAA TGTCACCTGCCAGGTGAGGAAGTTCTACCCCCAGAGACTACAGCTGACCTGGTTGGAGAA TGGAAACGTGTCCCGGACAGAAACGGCCTCAACCGTTACAGAGAACAAGGATGGTACCTA CAACTGGATGAGCTGGCTCCTGGTGAATGTATCTGCCCACAGGGATGATGTGAAGCTCAC CTGCCAGGTGGAGCATGACGGGCAGCCAGCGGTCAGCAAAAGCCATGACCTGAAGGTCTC AGCCCACCCGAAGGAGCAGGGCTCAAATACCGCCGCTGAGAACACTGGATCTAATGAACG GAACATCTATATTGTGGTGGGTGTGGTGTGCACCTTGCTGGTGGCCCTACTGATGGCGGC CCTCTACCTCGTCCGAATCAGACAGAAGAAAGCCCAGGGCTCCACTTCTTCTACAAGGTT GCATGAGCCCGAGAAGAATGCCAGAGAAATAACACAGGACACAAATGATATCACATATGC AGACCTGAACCTGCCCAAGGGGAAGAAGCCTGCTCCCCAGGCTGCGGAGCCCAACAACCA CACGGAGTATGCCAGCATTCAGACCAGCCCGCAGCCCGCGTCGGAGGACACCCTCACCTA TGCTGACCTGGACATGGTCCACCTCAACCGGACCCCCAAGCAGCCGGCCCCCAAGCCTGA GCCGTCCTTCTCAGAGTACGCCAGCGTCCAGGTCCCGAGGAAGTGAATGGGACCGTGGTT TGCTCTAGCACCCATCTCTACGCGCTTTCTTGTCCCACAGGGAGCCGCCGTGATGAGCAC AGCCAACCCAGTTCCCGGAGGGCTGGGGCGGTGCAGGCTCTGGGACCCAGGGGCCAGGGT GGCTCTTCTCTCCCCACCCCTCCTTGGCTCTCCAGCACTTCCTGGGCAGCCACGGCCCCC TCCCCCCACATTGCCACATACCTGGAGGCTGACGTTGCCAAACCAGCCAGGGAACCAACC TGGGAAGTGGCCAGAACTTCCTGGGGTCCAAGAACTCTTGTGCCTCCGTCCATCACCATG TGGGTTTTGAAGACCCTCGACTGCCTCCCCGATGCTCCGAAGCCTGATCTTCCAGGGTGG GGAGGAGAAAATCCCACCTCCCCTGACCTCCACCACCTCCACCACCACCACCACCACCAC CACCACCACTACCACCACCACCCAACTGGGGCTAGAGTGGGGAAGATTTCCCCTTTAGAT CAAACTGCCCCTTCCATGGAAAAGCTGGAAAAAAACTCTGGAACCCATATCCAGGCTTGG TGAGGTTGCTGCCAACAGTCCTGGCCTCCCCCATCCCTAGGCTAAAGAGCCATGAGTCCT GGAGGAGGAGAGGACCCCTCCCAAAGGACTGGAGACAAAACCCTCTGCTTCCTTGGGTCC CTCCAAGACTCCCTGGGGCCCAACTGTGTTGCTCCACCCGGACCCATCTCTCCCTTCTAG ACCTGAGCTTGCCCCTCCAGCTAGCACTAAGCAACATCTCGCTGTGGACGCCTGTAAATT ACTGAGAAATGTGAAACGTGCAATCTTGAAACTGAGGTGTTAGAAAACTTGATCTGTGGT GTTTTGTTTTGTTTTTTTTCTTAAAACAACAGCAACGTGATCTTGGCTGTCTGTCATGTG TTGAAGTCCATGGTTGGGTCTTGTGAAGTCTGAGGTTTAACAGTTTGTTGTCCTGGAGGG ATTTTCTTACAGCGAAGACTTGAGTTCCTCCAAGTCCCAGAACCCCAAGAATGGGCAAGA AGGATCAGGTCAGCCACTCCCTGGAGACACAGCCTTCTGGCTGGGACTGACTTGGCCATG TTCTCAGCTGAGCCACGCGGCTGGTAGTGCAGCCTTCTGTGACCCCGCTGTGGTAAGTCC AGCCTGCCCAGGGCTGCTGAGGGCTGCCTCTTGACAGTGCAGTCTTATCGAGACCCAACG CCTCAGTCTGCTCATCCGTAAAGTGGGGATAGTGAAGATGACACCCCTCCCCACCACCTC TCATAAGCACTTTAGGAACACACAGAGGGTAGGGATAGTGGCCCTGGCCGTCTATCCTAC CCCTTTAGTGACCGCCCCCATCCCGGCTTTCTGAGCTGATCCTTGAAGAAGAAATCTTCC ATTTCTGCTCTCAAACCCTACTGGGATCAAACTGGAATAAATTGAAGACAGCCAGGGGGA TGGTGCAGCTGTGAAGCTCGGGCTGATTCCCCCTCTGTCCCAGAAGGTTGGCCAGAGGGT GTGACCCAGTTACCCTTTAACCCCCACCCTTCCAGTCGGGTGTGAGGGCCTGACCGGGCC CAGGGCAAGCAGATGTCGCAAGCCCTATTTATTCAGTCTTCACTATAACTCTTAGAGTTG AGACGCTAATGTTCATGACTCCTGGCCTTGGGATGCCCAAGGGATTTCTGGCTCAGGCTG TAAAAGTAGCTGAGCCATCCTGCCCATTCCTGGAGGTCCTACAGGTGAAACTGCAGGAGC TCAGCATAGACCCAGCTCTCTGGGGGATGGTCACCTGGTGATTTCAATGATGGCATCCAG GAATTAGCTGAGCCAACAGACCATGTGGACAGCTTTGGCCAGAGCTCCCGTGTGGCATCT GGGAGCCACAGTGACCCAGCCACCTGGCTCAGGCTAGTTCCAAATTCCAAAAGATTGGCT TGTAAACCTTCGTCTCCCTCTCTTTTACCCAGAGACAGCACATACGTGTGCACACGCATG CACACACACATTCAGTATTTTAAAAGAATGTTTTCTTGGTGCCATTTTCATTTTATTTTA TTTTTTAATTCTTGGAGGGGGAAATAAGGGAATAAGGCCAAGGAAGATGTATAGCTTTAG CTTTAGCCTGGCAACCTGGAGAATCCACATACCTTGTGTATTGAACCCCAGGAAAAGGAA GAGGTCGAACCAACCCTGCGGAAGGAGCATGGTTTCAGGAGTTTATTTTAAGACTGCTGG GAAGGAAACAGGCCCCATTTTGTATATAGTTGCAACTTAAACTTTTTGGCTTGCAAAATA TTTTTGTAATAAAGATTTCTGGGTAATAATGAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_080792 unedited
AACTTTTGGATTTTGTAACACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCCC TGGCTTTATTTCTCGCGCGCTTGGGGTCTCTCCCAGTCTCCGTCTCTCCATTTCTCCTGG GGGGCGGGGAGGGGGGGTCTCCAAAAACCGCGGCGGCGGCGGCGGCCGCTCCAGGCGCCC GTTCCGGAGTCGGGGGGAGGCCCAGCCGGGAGGGGGGAATGGGGGGAGCCTTATTCATTT CCCCGCTCCAGCCTGCTCCCGCCCGAGCGCGCACTCACGGCCGCTCTCCCTCCTCGCTCC GCAGCCGCGGCCCATGGAGCCCGCCGGCCCGGCCCCCGGCCGCCTCGGGCCGCTGCTCTG CCTGCTGCTCGCCGCGTCCTGCGCCTGGTCAGGAGTGGCGGGTGAGGAGGAGCTGCAGGT GATTCAGCCTGACAAGTCCGTGTTGGTTGCAGCTGGAGAGACAGCCACTCTGCGCTGCAC TGCGACCTCTCTGATCCCTGTGGGGCCCATCCAGTGGTTCAGAGGAGCTGGACCAGGCCG GGAATTAATCTACAATCAAAAAGAAAGCCACTTCCCCCGGGTAACAACTGTTTCAGACCT CACAAAGAGAAACAACATGGACTTTTCCATCCGCATCGGTAACATCACCCCAGCAGATGC CGGCACCTACTACTGTGTGAAGTTCCGGATAGGGAGCCCCGATGACGTGGAGTTTAAGTC TGGAGCAGGCACTGAGCTGTCTGTGCGCGCCAAACCCTCTGCCCCCGTGGTATCGGGCCC TGCGGCGAGGGCCACACCTCAGCACACAGTGAGCTTCACCTGCGAGTCCCACGGCTTCTC ACCAGAGACTCACCCTGAAATGGTTCANAAATGGGGATGAGCTCTCAGACTTNCAGACAA CGTGGACCCCCGTAGAGAGAGCGTGTCCTACAGCATG >OriGene 3' read for NM_080792 unedited
ACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCATTATTACCCAAAAAT CTTTATTACAAAAATATTTTGCAAGCCAAAAGTTTAAGTTGCAACTATATACAAAATGGG GCCTGTTTCCTTCCCAGCAGTCTTAAAATAAACTCCTGAAACCATGCTCCTTCCGCAGGG TTGGTTCGACCTCTTCCTTTTCCTGGGGTTCAATACACAAGGTATGTGGATTCTCCAGGT TGCCAGGCTAAAGCTAAAGCTATACATCTTCCTTGGCCTTATTCCCTTATTTCCCCCTCC AAGAATTAAAAAATAAAATAAAATGAAAATGGCACCAAGAAAACATTCTTTTAAAATACT GAATGTGTGTGTGCATGCGTGTGCACACGTATGTGCTGTCTCTGGGTAAAAGAGAGGGAG ACGAAGGTTTACAAGCCAATCTTTTGGAATTTGGAACTAGCCTGAGCCAGGTGGCTGGGT CACTGTGGCTCCCAGATGCCACACGGGAGCTCTGGCCAAAGCTGTCCACATGGTCTGTTG GCTCAGCTAATTCCTGGATGCCATCATTGAAATCACCAGGTGACCATCCCCCAGAGAGCT GGGTCTATGCTGAGCTCCTGCAGTTTCACCTGTAGGACCTCCAGGAATGGGCAGGATGGC TCAGCTACTTTTACAGCCTGAGCCAGAAATCCCTTGGGCATCCCAAGGCCAGGAGTCATG AACATTAGCGTCTCAACTCTAAGAGTATAGTGAAGACTGAAAAATAGGGCTTGCGACATC TGCTTGCCCTGGGCCCNGTCAGGCCCTCACACCCGACTGGAGGGTGGGGGGNTAAGGGGT ACTGGGTCACACCCTTGGCCACCTTCTGGACAGAGGGGAAATANCCGAGCTTACACTGCA CATCCCCTGGCTGNCTCAATTATTCAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_080792 |
| Insert Size | 3860 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_080792.1, NP_542970.1 |
| RefSeq Size | 3872 bp |
| RefSeq ORF | 1515 bp |
| Locus ID | 140885 |
| UniProt ID | P78324 |
| Domains | ig, IGv, IGc1, IG |
| Protein Families | Druggable Genome, Phosphatase, Transmembrane |
| Gene Summary | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate, in-frame, splice donor site in the 3' coding region compared to variant 4. This variant encodes a shorter protein (isoform 1) compared to isoform 2. Variants 1, 2, and 3 encode the same protein (isoform 1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Cleavage of signal regulatory protein alpha (SIRPa) enhances inflammatory signaling
,Londino, JD;Gulick, D;Isenberg, JS;Mallampalli, RK;,
J. Biol. Chem.
,PubMed ID 26534964
[SIRPA]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC207315 | SIRPA (Myc-DDK-tagged)-Human signal-regulatory protein alpha (SIRPA), transcript variant 3 |
CNY 4,120.00 |
|
| RC207315L1 | Lenti ORF clone of Human signal-regulatory protein alpha (SIRPA), transcript variant 3, Myc-DDK-tagged |
CNY 6,520.00 |
|
| RC207315L2 | Lenti ORF clone of Human signal-regulatory protein alpha (SIRPA), transcript variant 3, mGFP tagged |
CNY 5,890.00 |
|
| RC207315L3 | Lenti ORF clone of Human signal-regulatory protein alpha (SIRPA), transcript variant 3, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC207315L4 | Lenti ORF clone of Human signal-regulatory protein alpha (SIRPA), transcript variant 3, mGFP tagged |
CNY 5,890.00 |
|
| RG207315 | SIRPA (tGFP-tagged) - Human signal-regulatory protein alpha (SIRPA), transcript variant 3 |
CNY 4,370.00 |
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