Neurexin 1 (NRXN1) (NM_138735) Human Untagged Clone

CAT#: SC120579

NRXN1 (untagged)-Human neurexin 1 (NRXN1), transcript variant beta



  "NM_138735" in other vectors (6)

CNY 7,030.00


货期*
2周

规格
    • 10 ug

Cited in 1 publication.

Product images

经常一起买 (4)
Goat Polyclonal Antibody against Neurexin 1
    • 100 ug

CNY 5,371.00


TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Synonyms Hs.22998; PTHSL2; SCZD17
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_138735 edited
GCTGTTTGGAGACTGCAGATTTGCATAGAGCCCCTTGCTTCACCAGCGTGTGTGGTTTTT
CTTTTCTTTTTTTCTTTTTCTTTTTCTTTTTCTGTTTCTCTCCCTTACTCCTTCGTCTGC
ATCTTCTTCTCAGCTGCCTTTCCGCCGTTCGATTCCCACTTCCTTCAGAAGGGCGCACTC
TTCCCTCTGAACCCCTCGCCGGGCGTAAGTGTCAGGAGGCGGCGGACGCGGAGATTGCCT
CGGGAGCAGGCGATGCGCGCCGCTGCTCCGCGCGCTGCCCGGGGGAGGCTGGCGCTAGCG
GGCGAGCCGGCCGGGGCTGAATGGAGGGAAGGGGCGCCTGGATTCCATGGGGTCTGCTTC
TGTCTTGAAAGGAGGTTGGGCCGGCGAAGTGGCCTCCCTAGTCCCCGCACACAAAGCTAA
ATGGATTTACCTAGTGGATTCGCGGTGGATGTCTGTCATGTAGAAGTGAGGACCTTCCAG
GAGGAGCTTTAAACAATTTCTCGGCCCCCCACCCGCCGGCACGCACTCTCGCCCGAAACT
CTTTGGGAGTATCTCTCGAGAACCTGGAGCCCTGGAAATCTGGGAGCAGCCACCCGCTCC
GCGCTTGCTGTTCCCGGGGCTGCCTTTCCGGACAAGCCCCTCTCCAGCTGCATTCGCCTC
GGCTATGTTTCGGATTGTTTGGGGTGCTAGGCACGGCGGACTCCAGGACCCCGAGAAGAC
TGTCCGAAGGAGGGAGAGGATGGGTGCCCTGGCGCGGTGAGGCGGCCGGCCCCTCAGCCC
ACTCCGCGCCGCCCGCTCCCCTGCGCCCTCTCCTCTCCCCGCGCCCCAAACTTTGCCTCC
CGCGGCGGCTGCCCCTCGGCGGGCGCCCCGCCATGTACCAGAGGATGCTCCGGTGCGGCG
CCGAGCTGGGCTCGCCCGGGGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGCAGGGGGGC
GCCTGGCCCTGCTTTGGATAGTCCCGCTCACCCTCAGCGGCCTCCTAGGAGTGGCGTGGG
GGGCATCCAGTTTGGGAGCGCACCACATCCACCATTTCCATGGCAGCAGCAAGCATCATT
CAGTGCCTATTGCAATCTACAGGTCACCGGCATCCTTGCGAGGCGGACACGCTGGGACGA
CATATATCTTTAGCAAAGGTGGTGGACAAATCACGTATAAGTGGCCTCCTAATGACCGAC
CCAGTACACGAGCAGACAGACTGGCCATAGGTTTTAGCACTGTTCAGAAAGAAGCCGTAT
TGGTGCGAGTGGACAGTTCTTCAGGCTTGGGTGACTACCTAGAACTGCATATACACCAGG
GAAAAATTGGAGTTAAGTTTAATGTTGGGACAGATGACATCGCCATTGAAGAATCCAATG
CAATCATTAATGATGGGAAATACCATGTAGTTCGTTTCACGAGGAGTGGTGGCAATGCCA
CGTTGCAGGTGGACAGCTGGCCAGTGATCGAGCGCTACCCTGCAGGGCGTCAGCTCACAA
TCTTCAATAGCCAAGCAACCATAATAATTGGCGGGAAAGAGCAGGGCCAGCCCTTCCAGG
GCCAGCTCTCTGGGCTGTACTACAATGGCTTGAAAGTTCTGAATATGGCAGCCGAAAACG
ATGCCAACATCGCCATAGTGGGAAATGTGAGACTGGTTGGTGAAGTGCCTTCCTCTATGA
CAACTGAGTCAACAGCCACTGCCATGCAATCAGAGATGTCCACATCAATTATGGAGACTA
CCACGACCCTGGCTACTAGCACAGCCAGAAGAGGAAAGCCCCCGACAAAAGAACCCATTA
GCCAGACCACAGATGACATCCTTGTGGCCTCAGCAGAGTGTCCCAGCGATGATGAGGACA
TTGACCCCTGTGAGCCGAGCTCAGGTGGGTTAGCCAACCCAACCCGAGCAGGCGGCAGAG
AGCCGTATCCAGGCTCAGCAGAAGTGATCCGGGAGTCCAGCAGCACCACGGGTATGGTCG
TTGGGATAGTAGCCGCTGCCGCCCTGTGCATCCTTATCCTCCTCTATGCCATGTACAAGT
ACAGAAACCGGGATGAAGGCTCATACCATGTGGACGAGAGTCGAAACTACATCAGTAACT
CAGCACAGTCCAATGGGGCTGTTGTAAAGGAGAAACAACCCAGCAGTGCGAAAAGCTCCA
ACAAAAATAAGAAAAACAAGGATAAAGAGTATTATGTCTGATCCCAAGATCTTAAATGGA
CACTTGTATAGAAATAGTCTTCATTTTATCTGAGACATAATATAAACTTATTTACTTTCC
TTTTTATGAAGCACATACAAAAGAAGACAGGGAATGCAATCAGGAAGGAAAGACTTTTTA
AAAAATAAAAACAAGTATCTCATGCTCTTGTTTCTCAAAAAAAAAAAAAAAAAA
Restriction Sites NotI-NotI     
ACCN NM_138735
Insert Size 2400 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation The insert of this clone has been fully sequenced and found to be perfect match to NM_138735.1.
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq NM_138735.1, NP_620072.1
RefSeq Size 3712 bp
RefSeq ORF 1329 bp
Locus ID 9378
UniProt ID P58400
Domains LamG
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs)
Gene Summary This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]
Transcript Variant: This variant (beta1) results from the use of an alternate promoter, referred to as beta. It contains an alternate 5' terminal exon and lacks most of the 5' exons and another exon in the 3' region compared to variant alpha2. The resulting isoform (beta1) is shorter with a distinct N-terminus lacking the EGF-like domain and containing fewer laminin G domains compared to isoform alpha2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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