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KCTD11 (NM_001002914) Human Untagged Clone
CAT＃: SC121957
KCTD11 (untagged)-Human potassium channel tetramerisation domain containing 11 (KCTD11)
CNY 2,400.00
CNY 3,990.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C17orf36; KCASH1; REN; REN/KCTD11 |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC121957 sequence for NM_001002914 edited (data generated by NextGen Sequencing)
ATGCTGGGGGCCATGTTTAGGGCCGGCACCCCCATGCCCCCCAACCTCAATTCCCAAGGA GGCGGCCACTACTTCATCGACCGGGATGGCAAGGCCTTCCGGCACATCCTCAATTTCCTG AGGCTGGGCCGCCTGGACCTGCCCCGTGGGTACGGAGAGACAGCGCTGCTCAGGGCAGAG GCTGACTTCTACCAGATCCGGCCCCTCCTGGATGCGCTGCGGGAACTGGAGGCCTCTCAG GGGACCCCTGCACCCACAGCTGCCCTGCTCCACGCAGATGTAGATGTCAGCCCCCGCCTG GTGCACTTCTCTGCTCGCCGGGGACCCCATCACTATGAGCTGAGCTCCGTCCAGGTGGAC ACCTTCCGAGCCAACCTTTTCTGCACCGACTCTGAGTGTCTAGGTGCTTTGCGGGCCCGA TTTGGTGTGGCCAGTGGGGATAGGGCAGAGGGGAGCCCACATTTTCATCTGGAGTGGGCC CCCCGCCCCGTGGAACTCCCCGAGGTGGAGTATGGGAGACTGGGGCTGCAGCCGCTGTGG ACTGGGGGGCCAGGAGAGCGGCGGGAGGTGGTGGGCACCCCAAGCTTCCTGGAGGAGGTG CTGCGGGTGGCTCTCGAGCACGGCTTCCGACTAGACTCTGTCTTCCCCGACCCCGAAGAC CTGCTCAACTCCAGGTCTCTGCGCTTTGTCCGGCACTGA Clone variation with respect to NM_001002914.2 213 c=>t >OriGene 5' read for NM_001002914 unedited
CCCCCCATTCCCCCGCCCGTTGACGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTAT ATAAGCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCG GCCGCGAATTCGGCACGAGGGTCTCTTAAAGGGCCCCGGGCCGCTGCCCTTAGGCCACTT CCTGGGGGCGGAGAGGACCTCAGCGGCTGCGGCGACACCCAGGGAAGGCGGCGCGGCCGG GTCCCGAAACTCCTGGCTGTTTCCATCAGAGCCCTCGGACACTCCCAGCCCGGGCTGAGC ACGCATCGTCGCTCCCCGGCGGATACAAGGGGGCTCCGCCATCCGCTCCCGTCAGTTCGG CCTCCATCTCCTGGGACCCGCGCCGGCAGCCAGGCCAGGCCTCTGAGTGGCCCCAGAGCC CTGGCTGGACTCGTCCACGGCGGCAGCGATCTGCCCGGGGTCTCGGAGGCCATCCCTTCA GAGTCGGCCCTGTGCTCGCCACCGTCACCTGCTGGTTGGATTCCGGAAACCCACTGTCTG AAGACCACAGAGGGGTGTCGCTGACCACCCCAAATCGGATACGTCCAGACCTCAAGCTCC CTTCCCCTCTCTGGCTGCCCTCTGCTCTTTTCATCTCTTCTCTCAACCTTTTGGGGATTT CTGTGTCCTGACACCACCTCCCCATCCACCACCAAAGTAGCCGGGGGTGAGCCCCAAACC TTACTGGNGTGTGCTCCACCTGTGCCTCCAACCCAGCGAATCTGACAGCTTCGACCCAAT TCTGCCCACACCCAGAAAGTTCTGCCTTTTCTTTTCTTTTCGGNGNCTCCTGTACTTCCC AAAATTCTCCTCCTCCTGTGCCCTCTTCGCCCCCTCCTATTGGGGCCCCGTGACCCTGCA TGTTGGGGGGCAC >OriGene 3' read for NM_001002914 unedited
NNNCCGTTCTACTATGNACGCGGCCGCATTCTAGNGATCGGTTTTTTTTTTTTTTTTTTG TGGTTCCAAAAGCAGTTTTATTTTTCTTCTTGTAAATCATGACCAGTGAGAAATAATGTG TGCCCCACCCCCCACCAGTGAAGAAGCTGTGCGTGAGTATCCCACCCGCTCTGGGACCCA GAAATCCCATCCCTTCCCATCTCCTCCCCCACTGTCCCAAACTCTTCGTCTCCTCTCTCT GCCCTGGGCGGGCTTGGGCCTTCCCCAGCTATCTCCTAGCAACAGGTCCATGGTTGCCTC AGCAACCAAGAGTTCCATACAGGCCTCAGAGGCCCAGCTAAGCCCAGTGACTTCTCTTAC CTCTCACCAGGAAGATCCCAGTGACTCAAACCCCAACAGGCCCCTCCTGGCTACGTGGTG ATGCATATACATGCGTGCACATAAACACACACACACACACACACACACACACACACACCC TGTGATTAAACTACTAATTGTCAACCACCTCACAGGTATACCACAGACACACCCTGTGCC AAAAGAGTCGCTTGGGAACCCCAAACAGGCCTGGACATGCGGACATCACAGACCCTGTGG TCAGCAACACAGATATGAACCCGGGTGCCCCGGGCCTATTCATCATTCAGCCTCACGGGG TGGTTTTCCCGCGCACCTGGAAAAAGGGCCGGACCCCCAGATACTACCCTTTTTCCCTGG GCAACCTGGCCATAGTTGGGAATTTTTCCAGAGAAGGGAGGTTCCAACCCCTTGGCATGG GGACTGGCCAACTCCCTTAATAAACCAAGGGGGGGGGGGGGCTTTTGCCCCCCCCAGGGA GGGTGGGGAAAATA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001002914 |
| Insert Size | 3000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001002914.1, NP_001002914.1 |
| RefSeq Size | 2780 bp |
| RefSeq ORF | 699 bp |
| Locus ID | 147040 |
| UniProt ID | Q693B1 |
| Protein Families | Ion Channels: Other |
| Gene Summary | Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.[UniProtKB/Swiss-Prot Function] |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205782 | KCTD11 (Myc-DDK-tagged)-Human potassium channel tetramerisation domain containing 11 (KCTD11) |
CNY 2,400.00 |
|
| RC205782L1 | Lenti ORF clone of Human potassium channel tetramerisation domain containing 11 (KCTD11), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC205782L2 | Lenti ORF clone of Human potassium channel tetramerisation domain containing 11 (KCTD11), mGFP tagged |
CNY 5,890.00 |
|
| RC205782L3 | Lenti ORF clone of Human potassium channel tetramerisation domain containing 11 (KCTD11), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC205782L4 | Lenti ORF clone of Human potassium channel tetramerisation domain containing 11 (KCTD11), mGFP tagged |
CNY 5,890.00 |
|
| RG205782 | KCTD11 (tGFP-tagged) - Human potassium channel tetramerisation domain containing 11 (KCTD11) |
CNY 4,000.00 |
