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HSD11B2 (NM_000196) Human Untagged Clone
CAT＃: SC122552
HSD11B2 (untagged)-Human hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2)
CNY 3,656.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AME; AME1; HSD2; HSD11K; SDR9C3 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000196 edited
CCCTCTCGCGCCCCAGGCCGGTGTACCCCCGCACTCCGCGCCCCGGCCTAGAAGCTCTCT CTCCCCGCTCCCCGGCCCGGCCCCCGCCCCGCCCCGCCCCAGCCCGCTGGGCCGCCATGG AGCGCTGGCCTTGGCCGTCGGGCGGCGCCTGGCTGCTCGTGGCTGCCCGCGCGCTGCTGC AGCTGCTGCGCTCAGACCTGCGTCTGGGCCGCCCGCTGCTGGCGGCGCTGGCGCTGCTGG CCGCGCTCGACTGGCTGTGCCAGCGCCTGCTGCCCCCGCCGGCCGCACTCGCCGTGCTGG CCGCCGCCGGCTGGATCGCGTTGTCCCGCCTGGCGCGCCCGCAGCGCCTGCCGGTGGCCA CTCGCGCGGTGCTCATCACCGGCTGTGACTCTGGTTTTGGCAAGGAGACGGCCAAGAAAC TGGACTCCATGGGCTTCACGGTGCTGGCCACCGTATTGGAGTTGAACAGCCCCGGTGCCA TCGAGCTGCGTACCTGCTGCTCCCCTCGCCTAAGGCTGCTGCAGATGGACCTGACCAAAC CAGGAGACATTAGCCGCGTGCTAGAGTTCACCAAGGCCCACACCACCAGCACCGGCCTGT GGGGCCTCGTCAACAACGCAGGCCACAATGAAGTAGTTGCTGATGCGGAGCTGTCTCCAG TGGCCACTTTCCGTAGCTGCATGGAGGTGAATTTCTTTGGCGCGCTCGAGCTGACCAAGG GCCTCCTGCCCCTGCTGCGCAGCTCAAGGGGCCGCATCGTGACTGTGGGGAGCCCAGCGG GGGACATGCCATATCCGTGCTTGGGGGCCTATGGAACCTCCAAAGCGGCCGTGGCGCTAC TCATGGACACATTCAGCTGTGAACTCCTTCCCTGGGGGGTCAAGGTCAGCATCATCCAGC CTGGCTGCTTCAAGACAGAGTCAGTGAGAAACGTGGGTCAGTGGGAAAAGCGCAAGCAAT TGCTGCTGGCCAACCTGCCTCAAGAGCTGCTGCAGGCCTACGGCAAGGACTACATCGAGC ACTTGCATGGGCAGTTCCTGCACTCGCTACGCCTGGCCATGTCCGACCTCACCCCAGTTG TAGATGCCATCACAGATGCGCTGCTGGCAGCTCGGCCCCGCCGCCGCTATTACCCCGGCC AGGGCCTGGGGCTCATGTACTTCATCCACTACTACCTGCCTGAAGGCCTGCGGCGCCGCT TCCTGCAGGCCTTCTTCATCAGTCACTGTCTGCCTCGAGCACTGCAGCCTGGCCAGCCTG GCACTACCCCACCACAGGACGCAGCCCAGGGCCCAAACCTGAGCCCCGGCCCTTCCCCAG CAGTGGCTCGGTGAGCCATGTGCACCTATGGCCCAGCCACTGCAGCACAGGAGGCTCCGT GAGCCCTTGGTTCCTCCCCGAAAACCCCCAGCATTACGATCCCCCAAGTGTCCTGGACCC TGGCCTAAAGAATCCCACCCCCACTTCATGCCCACTGCCGATGCCCAATCCAGGCCCGGT GAGGCCAAGGTTTCCCAGTGAGCCTCTGCGCCTCTCCACTGTTTCATGAGCCCAAACACC CTCCTGGCACAACGCTCTACCCTGCAGCTTGGAGAACTCCGCTGGATGGGGAGTCTCATG CAAGACTTCACTGCAGCCTTTCACAGGACTCTGCAGATAGTGCCTCTGCAAACTAAGGAG TGACTAGGTGGGTTGGGGACCCCCTCAGGATTGTTTCTCGGCACCAGTGCCTCAGTGCTG CAATTGAGGGCTAAATCCCAAGTGTCTCTTGACTGGCTCAAGAATTAGGGCCCCAACTAC ACACCCCCAAGCCACAGGGAAGCATGTACTGTACTTCCCAATTGCCACATTTTAAATAAA GACAAATTTTTATTTCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_000196 unedited
GGGTTTGGATTTGTATACGACTCATATAGGCGGCCGCGACTTCCCGGGATCCCTCTCGCG CCCCAGGCCGGTGTACCCCCGCACTCCGCGCCCCGGCCTAGAAGCTCTCTCTCCCCGCTC CCCGGCCCGGCCCCCGCCCCGCCCCGCCCCAGCCCGCTGGGCCGCCATGGAGCGCTGGCC TTGGCCGTCGGGCGGCGCCTGGCTGCTCGTGGCTGCCCGCGCGCTGCTGCAGCTGCTGCG CTCAGACCTGCGTCTGGGCCGCCCGCTGCTGGCGGCGCTGGCGCTGCTGGCCGCGCTCGA CTGGCTGTGCCAGCGCCTGCTGCCCCCGCCGGCCGCACTCGCCGTGCTGGCCGCCGCCGG CTGGATCGCGTTGTCCCGCCTGGCGCGCCCGCAGCGCCTGCCGGTGGCCACTCGCGCGGT GCTCATCACCGGCTGTGACTCTGGTTTTGGCAAGGAGACGGCCAAGAAACTGGACTCCAT GGGCTTCACGGTGCTGGCCACCGTATTGGAGTTGAACAGCCCCGGTGCCATCGAGCTGCG TACCTGCTGCTCCCCTCGCCTAAGGCTGCTGCAGATGGACCTGACCAAACCAGGAGACAT TAGCCGCGTGCTAGAGTTCACCAAGGCCCACACCACCAGCACCGGCCTGTGGGGCCTCGT CAACAACGCAGGCCACAATGAAGTAGTTGCTGATGCGGAGCTGTCTCCCATGGCCACTTT CCGTAGCTGCATGGAGGTGAATTTCTTTGGCGCGCTCGAGCTGACCCAAGGCCTCCTGCC TCTGCTGCGCAGCTAAAGGGCCGCATCGTGACTGTGGGGAGCCCACCGGGGGACATGCCA TATCCGTGCTTGGGGGCCCAATGGAACCTCCAAAGGGCGCGTGGCCCTCCTCATGGACAC ATTCGCCTGTGAACTCCT |
| Restriction Sites | Please inquire |
| ACCN | NM_000196 |
| Insert Size | 1944 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000196.2, NP_000187.2 |
| RefSeq Size | 1944 bp |
| RefSeq ORF | 1218 bp |
| Locus ID | 3291 |
| UniProt ID | P80365 |
| Protein Families | Druggable Genome |
| Protein Pathways | Androgen and estrogen metabolism, C21-Steroid hormone metabolism, Metabolic pathways |
| Gene Summary | There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
,Voisin, M;de Medina, P;Mallinger, A;Dalenc, F;Huc-Claustre, E;Leignadier, J;Serhan, N;Soules, R;Ségala, G;Mougel, A;Noguer, E;Mhamdi, L;Bacquié, E;Iuliano, L;Zerbinati, C;Lacroix-Triki, M;Chaltiel, L;Filleron, T;Cavaillès, V;Al Saati, T;Rochaix, P;Duprez-Paumier, R;Franchet, C;Ligat, L;Lopez, F;Record, M;Poirot, M;Silvente-Poirot, S;,
Proc. Natl. Acad. Sci. U.S.A.
,PubMed ID 29078321
[HSD11B2]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC207796 | HSD11B2 (Myc-DDK-tagged)-Human hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2) |
CNY 3,656.00 |
|
| RC207796L1 | Lenti ORF clone of Human hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC207796L2 | Lenti ORF clone of Human hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2), mGFP tagged |
CNY 5,890.00 |
|
| RC207796L3 | Lenti ORF clone of Human hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC207796L4 | Lenti ORF clone of Human hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2), mGFP tagged |
CNY 6,056.00 |
|
| RG207796 | HSD11B2 (tGFP-tagged) - Human hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2) |
CNY 5,256.00 |
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