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Myelin Protein Zero (MPZ) (NM_000530) Human Untagged Clone
CAT＃: SC122563
MPZ (untagged)-Human myelin protein zero (MPZ)
CNY 2,400.00
CNY 2,950.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CHM; CHN2; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; P0 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000530 edited
CACTTTCTCAACCCCACAGATGCTCCGGGCCCCTGCCCCTGCCCCAGCTATGGCTCCTGG GGCTCCCTCATCCAGCCCCAGCCCTATCCTGGCTGTGCTGCTCTTCTCTTCTTTGGTGCT GTCCCCGGCCCAGGCCATCGTGGTTTACACCGACAGGGAGGTCCATGGTGCTGTGGGCTC CCGGGTGACCCTGCACTGCTCCTTCTGGTCCAGTGAGTGGGTCTCAGATGACATCTCCTT CACCTGGCGCTACCAGCCCGAAGGGGGCAGAGATGCCATTTCGATCTTCCACTATGCCAA GGGACAACCCTACATTGACGAGGTGGGGACCTTCAAAGAGCGCATCCAGTGGGTAGGGGA CCCTCGCTGGAAGGATGGCTCCATTGTCATACACAACCTAGACTACAGTGACAATGGCAC GTTCACTTGTGACGTCAAAAACCCTCCAGACATAGTGGGCAAGACCTCTCAGGTCACGCT GTATGTCTTTGAAAAAGTGCCAACTAGGTACGGGGTCGTTCTGGGAGCTGTGATCGGGGG TGTCCTCGGGGTGGTGCTGTTGCTGCTGCTGCTTTTCTACGTGGTTCGGTACTGCTGGCT ACGCAGGCAGGCGGCCCTGCAGAGGAGGCTCAGTGCTATGGAGAAGGGGAAATTGCACAA GCCAGGAAAGGACGCGTCGAAGCGCGGGCGGCAGACGCCAGTGCTGTATGCAATGCTGGA CCACAGCAGAAGCACCAAAGCTGTCAGTGAGAAGAAGGCCAAGGGGCTGGGGGAGTCTCG CAAGGATAAGAAATAGCGGTTAGCGGGCCGGGCGGGGGATCGGGGGTTAGGGGTGGAGTC CGCCAAAGGCCCAAAGGTGATGGTCATCGAGATGGAGCTACGAAAGGATGAGCAGAGCCC GGAGCTCCGGCCTGCTGTCAAGTCCCCCAGCAGAACCAGCCTCAAAAACGCCCTCAAGAA CATGATGGGCCTGAACTCGGACAAGTGATCGCCACCCCCCCACCCCAGGCCCTGCCAGAG CAGGGGGACCTAGGCTCCTCTTACCCCCGTCTAGGTGCTTTCCCTCTTTGCTCCCCCGCC CTGCCCTGCCCTCACCTCCCTTTGAGATGTAAGTTTCATTCCAGAATTCATTCCCCAGCT CCATACTCTGTCCCCCCAGCTAATACCCAGAGCACCCAGATCAGACTCTCCTTCAGGGTT TATTTAGGTTATTATTTTTTATTTTTTAATCCATTCTTTGTTTGTTTACCTGTGCTCATC CTCTGCCCTTACACCCATGACTGAGGACCAATGACGTCATGTGGCTTTTGCAATTCACGC CCCCCTTAAGTCCTTAATGAAGAGCCAGCCCAAGTAGAGGGGCCCCTGATCCTCACACTT CAGTATAGCATTGGTTCCCCCTGACCACTTTGGAGCACTGTTCTGGGACTCCAGGTCTTG AGGAGAGAGACAGAGAGAGAGAATGGATCCTCATAGGTCAGGGAGTGGGGGAGGGGGCAA ATGAGCCTTAAGAAATGGTTTTTAAACAACCAAACAAAAAGCAGGAAAAACAAATGGGAA ATGGGGGGGCGGGGGGGAGGAAGAGGCTGCACTGCAGCCACAGGGGATTCTTAGGATTTT TCTACATTCTGTATATTTCTTCTCAAACCTCCAAATGTCCTTAAATGTTTAATAAACACT GACATTTCCAGAAAAAAAAAAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_000530 unedited
NNAAGAGTTCAAAATTTGTAATACGACTCACTATAGGGACCGGCCGCGAATTCGCACGAG GCACTTTCTCAACCCCACANAGCTCCGGGCCCCTGCCCCTGCCCCAGCTATGGCTCCTGG GGCTCCCTCATCCAGCCCCAGCCCTATCCTGGCTGTGCTGCTCTTCTCTTCTTTGGTGCT GTCCCCGGCCCAGGCCATCGTGGTTTACACCGACAGGGAGGTCCATGGTGCTGTGGGCTC CCGGGTGACCCTGCACTGCTCCTTCTGGTCCAGTGAGTGGGTCTCAGATGACATCTCCTT CACCTGGCGCTACCAGCCCGAAGGGGGCAGAGATGCCATTTCGATCTTCCACTATGCCAA GGGACAACCCTACATTGACGAGGTGGGGACCTTCAAAGAGCGCATCCAGTGGGTAGGGGA CCCTCGCTGGAAGGATGGCTCCATTGTCATACACAACCTAGACTACAGTGACAATGGCAC GTTCACTTGTGACGTCAAAAACCCTCCAGACATAGTGGGCAAGACCTCTCAGGTCACGCT GTATGTCTTTGAAAAAGTGCCAACTAGGTACGGGGTCGTTCTGGGAGCTGTGATCGGGGG TGTCCTCGGGGTGGTGCTGTTGCTGCTGCTGCTTTTCTACGTGGTTCGGTACTGCTGGCT ACGCAGGCAGGCGGCCCTGCAGAGGAGGCTCAGTGCTATGGAGAAGGGGAAATTGCACAA GCCAGGANAGGACGCGTCGAAGCGCGGGCGGCAGACGCCAGTGCTGTATGCAATGCTGGA CCACAGCAGAAGCACCAAAGCTGTCAGTGAGAAGAAGGCCAAGGGNGCTGGGGGAGTCTC GCAAGGATAAGAAATAGCGTTAGCGGGGCCGGGCGGGGATCGGGGGTTAGGGGTGGGAGT CCGGCAAAGCCCN >OriGene 3' read for NM_000530 unedited
GGGCTAAATGTCATGTTTCTTATTCATTTAAGGACATTTGGNAGTTTGNGTAATAAATAT ACAGCAATGTAGCAAAAATCCTAATAATCCCCTGTGGCTGCAGTGCATCCTCTTCCTCCC CCCCGCCCCCCCATTTCCCATTTGTTTTTCCTGCTTTTTGTTTGGTTGTTTAAAAACCAT TTCTTAAGGCTCATTTGCCCCCTCCCCCACTCCCTGACCTATGATGATCCATTCTCTCTC TCTGTCTCTCTCCTCAAGACCTGGAGTCCCAGAACAGTGCTCCAAAGTGGTCAGGGGGAA CCAATGCTATACTGAAGTGTGAGGATCAGGGGCCCCTCTACTTGGGCTGGCTCTTCATTA AGGACTTAAGGGGGGCGTGAATTGCAAAAGCCACATGACGTCATTGGTCCTCAGTCATGG GTGTAAGGGCAGAGGATGAGCACAGGTAAACAAACAAAGAATGGATTAAAAAATAAAAAA TAATAACCTAAATAAACCCTGAAGGATAGTCTGATCTGGGTGCTCTGGGTATTAGCTGGG GGGACAGAGTATGGAGCTGGGGAATGAATTCTGGAATGAAACTTACATCTCAAAGGGAGG TGAGGGCAGGGCATGGCGGGGGAGCAAAGAGGGAAAGCACCTAGACGGGGGTAAGATGAG CCTATGTCCCCCTGCTCTGGCAGGGCCTGGGGTGGGGGGGTGGCGATCACTTGTCCGAGT TCAGGCCCATCATGTTCTTGATGGCGTTTTTGAAGCTGGTTCTGCTGGGGGACTTGACAG CAGGCCCGAGCTCCGGGCTCTGCTCATCCTTTCGTAGCTCCATCTCGATGACCATCACCT TTGGGCCTTTTGCGGACTCCACCCCTTACCCCCGATCCCNCGCCCAGGCCCGCTAACCGC TATTTCTTATCCTTGCC |
| Restriction Sites | Please inquire |
| ACCN | NM_000530 |
| Insert Size | 1720 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000530.3, NP_000521.1 |
| RefSeq Size | 1718 bp |
| RefSeq ORF | 777 bp |
| Locus ID | 4359 |
| UniProt ID | P25189 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs) |
| Gene Summary | This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015] Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (MPZ). |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC202450 | MPZ (Myc-DDK-tagged)-Human myelin protein zero (MPZ) |
CNY 2,400.00 |
|
| RC202450L1 | Lenti ORF clone of Human myelin protein zero (MPZ), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC202450L2 | Lenti ORF clone of Human myelin protein zero (MPZ), mGFP tagged |
CNY 5,890.00 |
|
| RC202450L3 | Lenti ORF clone of Human myelin protein zero (MPZ), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC202450L4 | Lenti ORF clone of Human myelin protein zero (MPZ), mGFP tagged |
CNY 4,800.00 |
|
| RG202450 | MPZ (tGFP-tagged) - Human myelin protein zero (MPZ) |
CNY 4,000.00 |
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