USP6 (BC029495) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	HRP1; Tre-2; TRE2; TRE17; TRESMCR; USP6-short
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC029495 edited GAGTTCTACGGCAGTTACACACACGCAGTGGTATTCACAAGCGGTTTTGTGGACTCAAAG GTTTTCTCCCTGAGAGGCATAACCCAGGCCAGCTGATTCATCAGAATCAGGAAACTGGGC ATCTCTGTGGCCCTGAACATCCCAGGAGGCCGATCGTACAGAGACCTCTGGTGCCTGACC GCAGTTCACATCCACATCCCTGGAATAGACCATCACAGGCTCTTCACCCTTGGCAGGTGG ACACCATTCAACCTGCCGGGGCAGGATGGACATGGTAGAGAATGCAGATAGTTTGCAGGC ACAGGAGCGGAAGGACATACTTATGAAGTATGACAAGGGACACCGAGCTGGGCTGCCAGA GGACAAGGGGCCTGAGCCCGTTGGAATCAACAGCAGCATTGATCGTTTTGGCATTTTGCA GTCCTGCCCCTCCTGGGAGTCAGAGCCACAGGAAGGCCCTTGTCCTCCCTTCCCTGTGCC TTCTCCCGGGCTGAGCCCTGAGCTGGATAGGGACAGAGCCAGTCCTTTCTGGGGGTCGGC TCCCAGGCTTGGGCGGCTCCAGGCCCTGTGCACGTCCTCAGCTCTGCCTGGGTTGCCTTA CAGTGAGACGGAGCTGCCTCCTGTGACTGCACGGGAGGCGAAGAAAATTCGGCGGGAGAT GACACGAACGAGCAAGTGGATGGAAATGCTGGGAGAATGGGAGACATATAAGCACAGTAG CAAACTCATAGATCGAGTGTACAAGGGAATTCCCATGAACATCCGGGGCCCGGTGTGGTC AGTCCTCCTGAACATTCAGGAAATCAAGTTGAAAAACCCCGGAAGATACCAGATCATGAA GGAGAGGGGCAAGAGGTCATCTGAACACATCCACCACATCGACCTGGACGTGAGGACGAC TCTCCGGAACCATGTCTTCTTTAGGGATCGATATGGAGCCAAGTAAGCCTACGGGAGCCA CACAGTCCCAGCAGAGATGGGGTGAACGAGAGGGATGGGGACTTCCCCGGAGCAGAAGCC AGGGTCACCCAGGAGGGATGACAGAGCTGCCAAGAGCTCTCCTGGCCCAGGGAGCAGCCG GCACCATGAACCGAGCACCTCCCTGGTTCCAAGCCCTGGGCCAGGCTGGAACATGTGGGG CCAGAACCCAGGAGGATCCTGAGGAGACAGAAAACAGCAAAGAAAATCACACGCAATGGT GAAAGGTGCTCTCCCTGACCCACGGAGACCCATGGTAGGACCCACAGGAGGGTGGCAGGA TGGAGGGCCCATGAGCCTCCCCAGGCAACACAGCACCAAATGCTGGGAGAATTAGGGGTC CTGGAAACTGTCATCCAGGTCTGCTGGGAACATGACATGGCACAGCCACATTGGCAGCCA GTTGGGCAGTGGCTCACAAAGCTCAGTGGACTTGAACCACACATCCCCATGGTGTCACAG ATATTGAACCCACTGATTTGAAAACTGACATCCACATGAAACCTGCATGCCAGGTTCACT GCTTGATTCCTCATCACTCACACATGGAGCCTTCGGGGATGGCCTTCAACACGGGAATGG GGAGAGACAGGCTGGTCCTCCCTTCAAACGGAAGACCCAGTGAGAAAAGGGAACGAGCCA GTGATGCCTGCACGAACGTGGGTGGATCCTAGATGCATTTTGCTAAGGGAAAGAAGCCAG ACCCAATAAGCTACCATAGTAGGATTCCCATTCCTAGGCCATTCTGGAAAAGGCCAAACC ATAGGGACTGAGCAGCAGTCTGGGTGGCCAGGGGCTGACGGATCGGGGAGAGGCTGGGTG CATAGGGGAAACCCTGGAGATTTGGAAGATGATGGAGTCGCTCCAGGAGGGGCTGGAGCG GTGGCCGGGAGACTGCACATTGGTTTGGAACCATGGAGGAACTGTGCACCCAAAGACTGA ACTGGTGTGTGTGCAAAAAAAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC029495 unedited CGTCAAAATTTGTATACGACTCATATAGGCGGCCGCATAACTTCGTATAGCATACATTAT ACGAAGTTATGGATCAGGCCAAATCGGCCGAGCTCGAATTCGTCGAGAGCGGGAGTTCTA CGGCAGTTACACACACGCAGTGGTATTCACAAGCGGTTTTGTGGACTCAAAGGTTTTCTC CCTGAGAGGCATAACCCAGGCCAGCTGATTCATCAGAATCAGGAAACTGGGCATCTCTGT GGCCCTGAACATCCCAGGAGGCCGATCGTACAGAGACCTCTGGTGCCTGACCGCAGTTCA CATCCACATCCCTGGAATAGACCATCACAGGCTCTTCACCCTTGGCAGGTGGACACCATT CAACCTGCCGGGGCAGGATGGACATGGTAGAGAATGCAGATAGTTTGCAGGCACAGGAGC GGAAGGACATACTTATGAAGTATGACAAGGGACACCGAGCTGGGCTGCCAGAGGACAAGG GGCCTGAGCCCGTTGGAATCAACAGCAGCATTGATCGTTTTGGCATTTTGCAGTCCTGCC CCTCCTGGGAGTCAGAGCCACAGGAAGGCCCTTGTCCTCCCTTCCCTGTGCCTTCTCCCG GGCTGAGCCCTGAGCTGGATAGGGACAGAGCCAGTCCTTTCTGGGGGTCGGGCTCCAGGC TTGGGCGGCTCCAGGCCCTGTGCACGTCCTCAGCTCTGCCTGGGTTGCCTTACAGTGAGA CGGAGCTGCCTCCTGTGACTGCACGGNAGGCGAAGAAAATTCGGCGGNAGATGACACGAA CGAAGCAGTGGATGGAAATGCTGGGAGAATGGGAGGAATATTAGCCCAGTAGCAAACTCA TAGATCGAGTGTACAAGGGAATCCCAATGACATCCGGGGCCCGGTGTGGTCAATCCCTCT GAACATCAGGAAATCAGTTTAAA
Restriction Sites	Please inquire
ACCN	BC029495
Insert Size	1950 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC029495.1
RefSeq Size	1950 bp
Locus ID	9098
Protein Families	Druggable Genome, Protease
Gene Summary	Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.[UniProtKB/Swiss-Prot Function]

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