CLN8 (BC007725) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	C8orf61; ceroid-lipofuscinosis, neuronal 8; ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation); EPMR; FLJ39417
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC007725 edited GCCAAGCGCAGGGAGCCCGGCTGAGTGGCAGCCCAGATTGAAGATGGATACGTGACAATC CCAGGGACCGCTGCACTGACTTCATTTCCTTAGACAAGACACAGTGTAGGGCCCGGCCCG TGTTGGCCCCAGGACTCCTTTGGAATATAGCTGTGGACAATGAATCCTGCGAGCGATGGG GGCACATCAGAGAGCATTTTTGACCTGGACTATGCATCCTGGGGGATCCGCTCCACGCTG ATGGTCGCTGGCTTTGTCTTCTACTTGGGCGTCTTTGTGGTCTGCCACCAGCTGTCCTCT TCCCTGAATGCCACTTACCGTTCTTTGGTGGCCAGAGAGAAGGTCTTCTGGGACCTGGCG GCCACGCGTGCAGTCTTTGGTGTTCAGAGCACAGCCGCAGGCCTGTGGGCTCTGCTGGGG GACCCTGTGCTGCATGCCGACAAGGCGCGTGGCCAGCAGAACTGGTGCTGGTTTCACATC ACGACAGCAACGGGATTCTTTTGCTTTGAAAATGTTGCAGTCCACCTGTCCAACTTGATC TTCCGGACATTTGACTTGTTTCTGGTTATCCACCATCTCTTTGCCTTTCTTGGGTTTCTT GGCTGCTTGGTCAATCTCCAAGCTGGCCACTATCTAGCTATGACCACGTTGCTCCTGGAG ATGAGCACGCCCTTTACCTGCGTTTCCTGGATGCTCTTAAAGGCGGGCTGGTCCGAGTCT CTGTTTTGGAAGCTCAACCAGTGGCTGATGATTCACATGTTTCACTGCCGCATGGTTCTA ACCTACCACATGTGGTGGGTGTGTTTCTGGCACTGGGACGGCCTGGTCAGCAGCCTGTAT CTGCCTCATTTGACACTGTTCCTTGTCGGACTGGCTCTGCTTACGCTAATCATTAATCCA TATTGGACCCATAAGAAGACTCAGCAGCTTCTCAATCCGGTGGACTGGAACTTCGCACAG CCAGAAGCCAAGAGCAGGCCAGAAGGCAACGGGCAGCTGCTGCGGAAGAAGAGGCCATAG CTGCTCCAGCCGGGGCTCCGGGGCGGCAGCAGAGCTGGCACACCGATTCTGGGAAGCCCC GCGAATGATGGCTTTTGAATTAATGAGGCAGTGAATGTTTTGTGTTTACTTCTAAGGGAA ATACTAACTTTCTTTCGCATTAGTATTAATTTTGAAGTAGCTACAAAGTATTTTTAAGAA ATTATAATTTTATGACTGTCTGGCAGGCTCTGTCAGTTTAGCCGCGCCGGACCGTGTCAA GCATCTAGGAGAGGAGTCCATGGTGTCCAGGCATCGGGGCGTCACACCTGTTGAGGAGTG GGGTGGCTTTGAATGCTGGAAATGGCTTCATAGTGAAGTGCCTCCCACAGGGCGGGTGGG TCAGCGTTGACTCTTTCCAGCTGCACACTCATATGCCGTGTGTCTTATTCAGAAGTCACA TTCTTTTCAGTTGGAGAGAATTGGGCTAAGATAGAAAATAACATGATTTGTTCCTTATTA AAGTTTCCCAGCGTATGAAATTCTAAGCTGGGTGGGGTGGCTCACACCCGACGTAATCCC AGCACGTTGGGAGGCCGAGGCAGGTGGATCACTTGAGGCCAGGAGTTCGAGACCAGCCTG GTCAAGATGGTGAAACCCCATCTCTACTAAAATTACAAAAATTAGCCGGGTGTCGTGGCA CACACCTGTAATCCCAGCTATTTGGGAGGCCAAGGCAGGAGAATTGCCTGAACCCGGGAG GCGGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCACTCCAGCCTGGGTGAC GGAGCAAGACTCTCTCTCAAAAAAAAAAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC007725 unedited AGCCCGGCTGAGTGGCAGCCCAGCTTGAAGCAGGCTACGTGACAATCCCAGGGACCGCCG CACTGACTTCATTTCCTTAGACAAGACACCGTGTAGGGCCCGGCCCGTGTTGGCCCCAGG ACTCCTTTGGAATATGCCGTGGACAATGAACCCTGCGAGCGATGGGGGCACATCAGAAAG CATTTTTGACCTGGACAATGCATCCTGGGGGATCCGCTCCACGCTGATGGTCGCTGGCTT TGTCTTCTACTTGGGCGTCTTTGTGGTCTGCCACCAGCTTGTCCTTCTTCCCTGAATGCC ACTTACCGTTCTTTGGTGGCCAGAGAGAAGGTCTTCTGGGACCTGGCGGCCACGCGTGCC AGTCTTTGGTGTTCAGAGCACAGCCGCAGGCCTGTGGGCTCTTCTGGGGGACCCTGTGCT GCATGCCGACAAGGCGCGTGGCCAGCAGAACTGGTGCTGGTTTCACATCACGACAGCAAC GGGATTCTTTTGCTTTGAAAATGTTGCAGTCCACCTGTCCAACTTGATCTTCCGGACATT TGACTTGTTTCTGGTTATCCACCATCTCTTTGCCTTTCTTGGGTTTCTTGGCTGCTTGGT CAATCTCCAAGCTGGCCACTATCTAGCTATGACCACGTTGCTCCTGGAGATGAGCACGCC CTTTACCTGCGTTTCCTGGATGCTCTTAAAGGCGGGCTGGTCCGAGTCTCTGTTTTGGAA GCTCAACCAGTGGCTGATGATTCACATGTTTCACTGCCCGCATGTTCTACCTACCCATGT GGTGGGNNTGTGTTCTTGCACTTTGGACGCCTGNTCAGCAGCCTGTATCTGCCTCATTTG ACACTGTTCTTTGTTCGACTGCTCTGCTTACGCTAATCATTAATCCATATTGNACCCATN AGAAGACTCANCAGCTTCTCATT
Restriction Sites	Please inquire
ACCN	BC007725
Insert Size	1846 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC007725.2, AAH07725.1
RefSeq Size	1837 bp
RefSeq ORF	858 bp
Locus ID	2055
Protein Families	Druggable Genome, Transmembrane
Gene Summary	This gene encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reticulum (ER), and may recycle between the ER and ER-Golgi intermediate compartment. Mutations in this gene are associated with a disorder characterized by progressive epilepsy with cognitive disabilities (EPMR), which is a subtype of neuronal ceroid lipofuscinoses (NCL). Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain. [provided by RefSeq, Jul 2017]

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