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EXOSC10 (NM_001001998) Human Untagged Clone
CAT＃: SC124367
EXOSC10 (untagged)-Human exosome component 10 (EXOSC10), transcript variant 1
CNY 6,488.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_001001998, the custom clone sequence may differ by one or more nucleotides
ATGGCGCCACCCAGTACCCGGGAGCCCAGGGTCCTGTCGGCGACCAGCGCAACCAAATCCGACGGAGAGA TGGTGCTGCCAGGCTTCCCGGACGCCGACAGCTTTGTGAAGTTTGCTCTTGGGTCCGTGGTGGCAGTCAC CAAGGCATCTGGGGGCCTACCACAGTTTGGCGATGAGTATGATTTTTACCGAAGTTTTCCTGGCTTCCAA GCATTTTGCGAAACACAGGGAGACAGGTTGCTTCAGTGCATGAGCAGAGTAATGCAGTACCATGGGTGTC GCAGCAACATTAAGGATCGAAGTAAAGTGACTGAGCTGGAAGACAAGTTTGATTTACTAGTTGATGCCAA TGATGTAATTCTGGAGAGAGTGGGTATTTTACTGGATGAAGCCTCAGGTGTAAACAAGAATCAACAGCCT GTCCTCCCTGCCGGCTTGCAGGTCCCCAAAACGGTAGTGTCCAGCTGGAACCGTAAGGCAGCAGAATATG GCAAAAAAGCAAAATCTGAAACTTTCCGGCTGCTTCATGCAAAAAATATCATCCGACCTCAGCTCAAGTT TCGAGAGAAGATTGACAATTCCAACACACCATTTCTTCCTAAAATCTTCATCAAACCCAATGCTCAGAAA CCTCTCCCTCAAGCTCTCTCTAAGGAAAGGCGGGAACGCCCACAGGATCGTCCTGAGGACTTGGACGTCC CCCCTGCACTGGCTGATTTCATCCATCAGCAGAGAACCCAGCAGGTTGAGCAAGACATGTTTGCACATCC TTATCAATATGAACTAAATCACTTTACCCCAGCAGATGCAGTGCTTCAAAAGCCACAACCCCAGTTATAC AGACCTATAGAAGAGACACCATGCCATTTCATATCCTCCCTGGATGAACTCGTGGAACTCAACGAAAAGC TCTTGAATTGTCAGGAATTTGCAGTTGACTTGGAGCACCACTCTTACAGGAGCTTCCTGGGACTGACCTG CCTGATGCAAATTTCTACTCGGACGGAAGACTTCATCATTGACACCCTCGAGCTTCGAAGTGACATGTAC ATTCTCAATGAGAGCCTCACAGACCCAGCCATCGTTAAGGTCTTTCATGGTGCTGATTCAGACATAGAAT GGCTACAGAAAGACTTTGGGTTGTATGTAGTAAACATGTTTGATACTCATCAGGCAGCACGCCTTCTTAA CCTGGGCAGGCACTCACTCGATCATCTCCTGAAACTCTACTGCAACGTGGACTCAAACAAGCAATATCAG CTGGCTGATTGGAGAATACGCCCTCTGCCCGAGGAGATGCTCAGCTACGCCCGGGATGACACCCATTACC TGCTATATATCTATGACAAAATGAGGCTGGAGATGTGGGAGCGCGGCAACGGGCAGCCGGTGCAGCTGCA GGTGGTGTGGCAACGGAGCAGGGACATCTGCCTCAAGAAATTCATCAAACCTATCTTCACGGATGAGTCC TACCTTGAACTCTATAGGAAGCAGAAGAAGCACCTTAACACACAGCAGTTGACAGCCTTTCAGCTGCTGT TTGCCTGGAGGGATAAAACAGCTCGCAGGGAAGATGAAAGTTACGGATATGTACTGCCAAACCACATGAT GCTGAAAATAGCTGAAGAACTGCCTAAGGAACCTCAGGGCATCATAGCTTGCTGCAACCCAGTACCGCCC CTTGTGCGGCAGCAGATCAACGAAATGCACCTTTTAATCCAGCAGGCCCGAGAGATGCCCCTGCTCAAGT CTGAAGTTGCAGCCGGAGTGAAGAAGAGCGGACCGCTGCCCAGTGCTGAGAGATTGGAGAATGTTCTCTT TGGACCTCACGACTGCTCCCATGCCCCTCCGGATGGCTATCCAATCATCCCAACCAGTGGATCTGTGCCA GTTCAGAAGCAGGCGAGCCTCTTCCCTGATGAAAAAGAAGATAACTTGCTGGGTACCACATGCCTGATTG CCACAGCTGTCATCACGTTATTTAATGAACCTAGTGCTGAAGACAGTAAAAAGGGTCCATTGACAGTTGC ACAGAAAAAAGCCCAGAACATCATGGAGTCCTTTGAAAATCCATTTAGGATGTTTCTGCCCTCACTGGGA CACCGTGCTCCCGTCTCTCAGGCAGCGAAGTTCGATCCATCAACCAAAATCTATGAAATCAGCAACCGCT GGAAGCTGGCCCAGGTACAAGTACAAAAAGACTCTAAAGAAGCTGTCAAGAAGAAGGCAGCTGAGCAAAC AGCTGCCCGGGAACAGGCAAAGGAGGCGTGCAAAGCTGCAGCAGAACAGGCCATCTCCGTCCGACAGCAG GTCGTGCTAGAAAATGCTGCAAAGAAGAGAGAGCGAGCAACAAGCGACCCAAGGACCACAGAACAGAAAC AAGAGAAGAAACGACTCAAAATTTCCAAGAAGCCAAAGGACCCAGAGCCACCAGAAAAAGAGTTTACGCC TTACGACTACAGCCAGTCAGACTTCAAGGCTTTTGCTGGAAACAGCAAATCCAAAGTTTCTTCTCAGTTT GATCCAAATAAACAGACCCCGTCTGGCAAGAAATGCATTGCAGCCAAAAAAATTAAACAGTCGGTGGGAA ACAAAAGCATGTCCTTTCCAACTGGAAAGTCAGACAGAGGCTTCAGGTACAACTGGCCACAGAGATAG >OriGene 5' read for NM_001001998 unedited
TTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGAAAAAATGGCGCCA CCCAGTACCCGGGAGCCCAGGGTCCTGTCGGCGACCAGCGCAACCAAATCCGACGGAGAG ATGGTGCTGCCAGGCTTCCCGGACGCCGACAGCTTTGTGAAGTTTGCTCTTGGGTCCGTG GTGGCAGTCACCAAGGCATCTGGGGGCCTACCACAGTTTGGCGATGAGTATGATTTTTAC CGAAGTTTTCCTGGCTTCCAAGCATTTTGCGAAACACAGGGAGACAGGTTGCTTCAGTGC ATGAGCAGAGTAATGCAGTACCATGGGTGTCGCAGCAACATTAAGGATCGAAGTAAAGTG ACTGAGCTGGAAGACAAGTTTGATTTACTAGTTGATGCCAATGATGTAATTCTGGAGAGA GTGGGTATTTTACTGGATGAAGCCTCAGGTGTAAACAAGAATCAACAGCCTGTCCTCCCT GCCGGCTTGCAGGTCCCCAAAACGGTAGTGTCCAGCTGGAACCGTAAGGCAGCAGAATAT GGCAAAAAAGCAAAATCTGAAACTTTCCGGCTGCTTCATGCAAAAAATATCATCCGACCT CAGCTCAAGTTTCGAGAGAAGATTGACAATTCCAACACACCATTTTCTTCCTAAAATCTT CATCAAACCCAATGCTCAGAAACCTCTCCCTCAAGCTCTCTCTAGGAAAGGCGGGAACGC CACAGGATCGTCCTGAGACTTGGACGTNCCCCCTGACTGGCTGATTTATCCATAGCAGAG ACCCAGCAGNTGAGCAAGAATGTTTGCACTCCTTATATATGACTAAATACTTTACCCAGC GATGCAGGCTTCAAACCCAACCCAGTTTCAGACTATGAAAGACACTGCCTTTCTATCTCC TGGAGACTCGGGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001001998 |
| Insert Size | 3000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001001998.1, NP_001001998.1 |
| RefSeq Size | 2834 bp |
| RefSeq ORF | 2658 bp |
| Locus ID | 5394 |
| UniProt ID | Q01780 |
| Protein Pathways | RNA degradation |
| Gene Summary | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC210055 | EXOSC10 (Myc-DDK-tagged)-Human exosome component 10 (EXOSC10), transcript variant 1 |
CNY 6,480.00 |
|
| RC210055L1 | Lenti ORF clone of Human exosome component 10 (EXOSC10), transcript variant 1, Myc-DDK-tagged |
CNY 8,880.00 |
|
| RC210055L2 | Lenti ORF clone of Human exosome component 10 (EXOSC10), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC210055L3 | Lenti ORF clone of Human exosome component 10 (EXOSC10), transcript variant 1, Myc-DDK-tagged |
CNY 8,880.00 |
|
| RC210055L4 | Lenti ORF clone of Human exosome component 10 (EXOSC10), transcript variant 1, mGFP tagged |
CNY 8,880.00 |
|
| RG210055 | EXOSC10 (tGFP-tagged) - Human exosome component 10 (EXOSC10), transcript variant 1 |
CNY 8,080.00 |
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