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SRC (NM_005417) Human Untagged Clone
CAT＃: SC125208
SRC (untagged)-Human v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC), transcript variant 1
CNY 4,000.00
| Cited in 4 publications. |
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热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ASV; c-SRC; p60-Src; SRC1; THC6 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene ORF within SC125208 sequence for NM_005417 edited (data generated by NextGen Sequencing)
ATGGGTAGCAACAAGAGCAAGCCCAAGGATGCCAGCCAGCGGCGCCGCAGCCTGGAGCCC GCCGAGAACGTGCACGGCGCTGGCGGGGGCGCTTTCCCCGCCTCGCAGACCCCCAGCAAG CCAGCCTCGGCCGACGGCCACCGCGGCCCCAGCGCGGCCTTCGCCCCCGCGGCCGCCGAG CCCAAGCTGTTCGGAGGCTTCAACTCCTCGGACACCGTCACCTCCCCGCAGAGGGCGGGC CCGCTGGCCGGTGGAGTGACCACCTTTGTGGCCCTCTATGACTATGAGTCTAGGACGGAG ACAGACCTGTCCTTCAAGAAAGGCGAGCGGCTCCAGATTGTCAACAACACAGAGGGAGAC TGGTGGCTGGCCCACTCGCTCAGCACAGGACAGACAGGCTACATCCCCAGCAACTACGTG GCGCCCTCCGACTCCATCCAGGCTGAGGAGTGGTATTTTGGCAAGATCACCAGACGGGAG TCAGAGCGGTTACTGCTCAATGCAGAGAACCCGAGAGGGACCTTCCTCGTGCGAGAAAGT GAGACCACGAAAGGTGCCTACTGCCTCTCAGTGTCTGACTTCGACAACGCCAAGGGCCTC AACGTGAAGCACTACAAGATCCGCAAGCTGGACAGCGGCGGCTTCTACATCACCTCCCGC ACCCAGTTCAACAGCCTGCAGCAGCTGGTGGCCTACTACTCCAAACACGCCGATGGCCTG TGCCACCGCCTCACCACCGTGTGCCCCACGTCCAAGCCGCAGACTCAGGGCCTGGCCAAG GATGCCTGGGAGATCCCTCGGGAGTCGCTGCGGCTGGAGGTCAAGCTGGGCCAGGGCTGC TTTGGCGAGGTGTGGATGGGGACCTGGAACGGTACCACCAGGGTGGCCATCAAAACCCTG AAGCCTGGCACGATGTCTCCAGAGGCCTTCCTGCAGGAGGCCCAGGTCATGAAGAAGCTG AGGCATGAGAAGCTGGTGCAGTTGTATGCTGTGGTTTCAGAGGAGCCCATTTACATCGTC ACGGAGTACATGAGCAAGGGGAGTTTGCTGGACTTTCTCAAGGGGGAGACAGGCAAGTAC CTGCGGCTGCCTCAGCTGGTGGACATGGCTGCTCAGATCGCCTCAGGCATGGCGTACGTG GAGCGGATGAACTACGTCCACCGGGACCTTCGTGCAGCCAACATCCTGGTGGGAGAGAAC CTGGTGTGCAAAGTGGCCGACTTTGGGCTGGCTCGGCTCATTGAAGACAATGAGTACACG GCGCGGCAAGGTGCCAAATTCCCCATCAAGTGGACGGCTCCAGAAGCTGCCCTCTATGGC CGCTTCACCATCAAGTCGGACGTGTGGTCCTTCGGGATCCTGCTGACTGAGCTCACCACA AAGGGACGGGTGCCCTACCCTGGGATGGTGAACCGCGAGGTGCTGGACCAGGTGGAGCGG GGCTACCGGATGCCCTGCCCGCCGGAGTGTCCCGAGTCCCTGCACGACCTCATGTGCCAG TGCTGGCGGAAGGAGCCTGAGGAGCGGCCCACCTTCGAGTACCTGCAGGCCTTCCTGGAG GACTACTTCACGTCCACCGAGCCCCAGTACCAGCCCGGGGAGAACCTCTAG Clone variation with respect to NM_005417.3 >OriGene 5' read for NM_005417 unedited
NAGTTCGCAATTTGTATACGACTCACTATAGGGCGGCCGCGAATTCGCACGAGGGCCGGA CGGCCAGGCCGCCGTCTGCCCGTCCCGCTGGACGTCCCGCGGTCCGCCCTCCCGTGCGTC CGTCTGCCGGTGAGCCCGCCCGCCCGCCGGCCCAGAACAGAGAACAGAAGCTCAGAGAAG TGAAGCAACTTGCCCAGCTATGAGAGACAGAGCCAGGATTTGAAACCAGATGAGGACGCT GAGGCCCAGAGAGGGAAAGCCACTTGCCTAGGGACACACAGCGGGGAGAGGTGGAGCAGG GCCTCTATTTCGAGACCCCTGACTCCACACCTGGTGTTTGTGCCAAGACCCCAGGCTGCC TCCCAGGTCCTCTGGGACAGCCCCTGCCTTCTACCAGGACCATGGGTAGCAACAAGAGCA AGCCCAAGGATGCCAGCCAGCGGCGCCGCAGCCTGGAGCCCGCCGAGAACGTGCACGGCG CTGGCGGGGGCGCTTTCCCCGCCTCGCAGACCCCCAGCAAGCCAGCCTCGGCCGACGGCC ACCGCGGCCCCAGCGCGGCCTTCGCCCCCGCGGCCGCCGAGCCCAAGCTGTTCGGAGGCT TCAACTCCTCGGACACCGTCACCTCCCCGCAGAGGGCGGGCCCGCTGGCCGGTGGAGTGA CCACCTTTGTGGCCCTCTATGACTATGAGTCTAGGACGGAGACAGACCTGTCCTTCAAGA AGGCGAGCGGGCTCCGATTGTCAACAACACAAAGGGAGACTGGTGGCTGGCCCACTCGCT CAGCACAGGACAGACAGGCTACATTCCCAGCAACTAAGTGGCGCCCTTCGACTCCTTCCA GGCTGAAGGATTGGTATTTTGGGCAGATCACCAGACGGGGAGTG >OriGene 3' read for NM_005417 unedited
NANTTGCACTGGGGAGGCGTCACAGGGATGCCACCCGGGATCTGTTCAGGAAACAGCTAT GACCGTGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTCTGAGGTCTGTTTGT GTTTAATCAGACAATATGCAAAGTATTTACAACCAATTCTGGATACCCCCCCACCCCCCG CAAGTCTGGGCCTTGGAATTTCGGAGCCCCAGGCCCGGCCCAGAGCCAGGGGTCCCCCAG GCCTCTGCATAGTCATCTGAAATCTACAAAACACTGTTAAAAAAAAAAAGGACAGTATTA AGACACCTTACACAAAGGGCCTTATGCAGTTGGAGAGGGATTTGAGAGCTCGCTGGGGTG AGTGAGCCCAGATTTGACTGGAATGGACGGGAGAAGACTTGGGTAATAAAGACGTATGAA AGGAAAAGTTGAAATTTCATAGGCAGGCACTGCTTGGCCTCCTTCCCCACTGGCAGGGCC TTGCTGGCTTCAAGAACCCCTGCAGTGGGAATGTTATTGCTATGATGAGGGGNGCCATGG TGAATGTACAACAATTGTTGGNGGACGNGAGCGNGGGGACATTNTTACATGTTAAATATT GGACGCACATGGAGACACGCACACATGCACACACATACACACACACAGGGACCCTTTGCA AGATGCCACNACTTGTAGCTTGCCTTTTACAGATGGGCACACTGGGCCCAGGGAGATCAA CACACAACCAAAGGCCGACAGAGCANAAGCCNATTTNCTTGATGTCAAGCGTTGNCTTTC ATCTTTGCTGTCCAAG |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_005417 |
| Insert Size | 1611 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | no |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005417.3 |
| RefSeq Size | 4131 bp |
| RefSeq ORF | 1611 bp |
| Locus ID | 6714 |
| UniProt ID | P12931 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Stem cell relevant signaling - JAK/STAT signaling pathway |
| Protein Pathways | Adherens junction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, GnRH signaling pathway, Tight junction, VEGF signaling pathway |
| MW | 59.8 kDa |
| Gene Summary | This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
A Dimerization Function in the Intrinsically Disordered N-Terminal Region of Src
,Spassov, DS;Ruiz-Saenz, A;Piple, A;Moasser, MM;,
Cell Rep
,PubMed ID 30304684
[SRC]
|
|
All-trans-retinoic acid activates the pro-invasive Src-YAP-Interleukin 6 axis in triple-negative MDA-MB-231 breast cancer cells while cerivastatin reverses this action
,Mezquita, B;Mezquita, P;Pau, M;Gasa, L;Navarro, L;Samitier, M;Pons, M;Mezquita, C;,
Sci Rep
,PubMed ID 29728589
[SRC]
|
|
Frank-ter Haar Syndrome Protein Tks4 Regulates Epidermal Growth Factor-dependent Cell Migration
,Gábor Bögel, Annamária Gujdár, Miklós Geiszt, Árpád Lányi, Anna Fekete, Szabolcs Sipeki, Julian Downward, and László Buday,
J. Biol. Chem., Sep 2012; 287: 31321 - 31329.
[SRC]
|
|
Src tyrosine kinase phosphorylation of nuclear receptor HNF4a correlates with isoform-specific loss of HNF4a in human colon cancer
,Karthikeyani Chellappa, Lucy Jankova, Jake M. Schnabl, Songqin Pan, Yann Brelivet, Caroline L-S. Fung, Charles Chan, Owen F. Dent, Stephen J. Clarke, Graham R. Robertson, and Frances M. Sladek,
PNAS, Feb 2012; 109: 2302 - 2307.
[SRC]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208622 | SRC (Myc-DDK-tagged)-Human v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC), transcript variant 1 |
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| RC208622L1 | Lenti ORF clone of Human v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC208622L2 | Lenti ORF clone of Human v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC), transcript variant 1, mGFP tagged |
CNY 8,384.00 |
|
| RC208622L3 | Lenti ORF clone of Human v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC208622L4 | Lenti ORF clone of Human v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC), transcript variant 1, mGFP tagged |
CNY 8,384.00 |
|
| RG208622 | SRC (tGFP-tagged) - Human v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC), transcript variant 1 |
CNY 7,584.00 |
|
| SC323642 | SRC (untagged)-Kinase deficient mutant (K298M) of Human v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC), transcript variant 1 |
CNY 4,000.00 |
