Dematin (DMTN) (BC017445) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	dematin; DMT; erythrocyte membrane protein band 4.9; erythrocyte membrane protein band 4.9 (dematin); FLJ78462; FLJ98848
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC017445 edited GTTGCCTGGTTGTGAGAGTCAGGGGAGCAGGGACAGGTCCAAGACAAGGAAGGCAGTTGG GCTGTGGGAATGGGGAGCCCAGGGAAGGCCTCCAGAGCTGGCCTGGAGAGTCACCGCCGA GGGATGAGGACGCGCCAGCCCGGGGGAACGCGCCAGCTGCTTTCGCGGCCCCAAGCGCGC AGTGCCCAGCAGCCGCGCCGAGCCTGACACGCTGTCCTCTCCCCTCGCGCACAGGGCTCT GCGAGTGACCCGGCGGGCGAGCTCCGTGCTGCATGGAACGGCTGCAGAAGCAACCACTTA CCTCCCCCGGGAGCGTGAGCCCCTCCCGAGATTCCAGTGTGCCTGGCTCTCCCTCCAGCA TCGTGGCCAAGATGGACAATCAGGTGCTGGGCTACAAGGACCTGGCTGCCATCCCCAAGG ACAAGGCCATCCTGGACATCGAGCGGCCCGACCTCATGATCTACGAGCCTCACTTCACTT ATTCCCTCCTGGAACACGTGGAGCTGCCTCGCAGCCGCGAGCGCTCGCTGTCACCCAAAT CCACATCCCCCCCACCATCCCCAGAGGTGTGGGCGGACAGCCGGTCGCCTGGAATCATCT CTCAGGCCTCGGCCCCCAGAACCACTGGAACCCCCCGGACCAGCCTGCCCCATTTCCACC ACCCTGAGACCTCCCGCCCAGATTCCAACATCTACAAGAAGCCTCCCATCTATAAGCAGA GAGAGTCCGTGGGAGGCAGCCCTCAGACCAAGCACCTCATCGAGGATCTCATCATCGAGT CATCCAAGTTTCCTGCAGCCCAGCCCCCAGACCCCAACCAGCCAGCCAAAATCGAAACCG ACTACTGGCCATGCCCCCCGTCTCTGGCTGTTGTGGAGACAGAATGGAGGAAGCGGAAGG CGTCTCGGAGGGGAGCAGAGGAAGAGGAGGAGGAGGAAGATGACGACTCTGGAGAGGAGA TGAAGGCTCTCAGGGAGCGTCAGAGAGAGGAACTCAGTAAGGTTACTTCCAACTTGGGAA AGATGATCTTGAAAGAAGAGATGGAAAAGTCATTGCCGATCCGAAGGAAAACCCGCTCTC TGCCTGACCGGACACCCTTCCATACCTCCTTGCACCAGGGAACGTCTAAATCTTCCTCTC TCCCCGCCTATGGCAGGACCACCCTGAGCCGGCTACAGTCCACAGAGTTCAGCCCATCAG GGAGTGAGACTGGAAGCCCAGGCCTGCAGAACGGAGAGGGCCAGAGGGGGAGGATGGACC GGGGGAACTCCCTGCCCTGTGTGCTGGAGCAGAAGATCTATCCCTATGAAATGCTAGTGG TGACCAACAAGGGGCGAACCAAGCTGCCACCGGGGGTGGATCGGATGCGGCTTGAGAGGC ATCTGTCTGCCGAGGACTTCTCAAGGGTATTTGCCATGTCCCCTGAAGAGTTTGGCAAGC TGGCTCTGTGGAAGCGGAATGAGCTCAAGAAGAAGGCCTCTCTCTTCTGATGGCCCCCAC CTGCTCCGGGACGGCCCCCTTACCCCTGCTGCTTCAGGGTTTTTCCCCGGCGGGTTGGGA GGGGCAGGAGGTGGGGTGGAAATAGGGTGGGCTCCTTTCCTCAGGTAGAGTGGGGGGCCA AAACCTCTGCAGTCCCCGGCAGTGAGCTATGGACTTTCTTCCCCCTCACAAGGCTGGGGG CCTCCTGCTCTCGTCCCTGGCCCTCCCTGCACAGGGCAAAGCCAGTCTGGGCTCTGGCAC ACAGAGTTCATGTTTGCGCCCTCTCCCTGCCCCTCACCCCAGAGGGTGAGGAGGAATGAG GGGCATTGGTGGTTAGGCCGGTTGGCTGTCTTGAACAGCTGGAGGGAAGATGCAGGGGTG GGAAGCGGCCAGGCAGAAAGAGCTCCAGGCTCTTGTGTCGCCCACCCAGCCCTCCCATAC TCACTCCTGACAGCTTTCCTGCACTGCAGCTTCCTGCTCCTCTGACTCTAGTGGGAACAG GCCCCAGCTCAGCCTCCGGCAGGGAGGTCACCCCTCCACTTCAGCTTGCCCTGACCTCCG CTCGCAAACCCCGAGCTTCCAAGCCTTTTGCTCCAGCCCTGCGGCTTCCCCAGAAGCCTG GGCTTAGGGTGGAGATGCCGCCTACACACGATCCTGGCCCTCCACCTGCCTCCAGGCCAC GAAATGGGAATTCCAGCACTAAGCCAGGCACCGGGCAGAAGCTGGGCCTTCCGCCTCCCT TGGATGGGGTCAAGAGGCCAGGCCTGGCACATTTTGGAGTGTCCTGGCTACCAGCTTTCA CCTACACCCACGCACCCCCCCACACACTATGCTCTCTCAAGAATGTAATTTATTGGGGCC CCCCCCAGCTGCTTTCCTCACCTGCCCCTGCCCTACCTTACACCCCCAGCTTGACTTCTT TCCAGTCCACGTGTGTATATAATGATATCTATATTTTTGCCCAGGTCTGGGTATTGCTCC TGCCCAGACCCTGACATCCCTTTCCACTGTGTGTGTGACCATGCTGGGGGAGGGGGACTC TGCTTGGAATTAAAAGGTTGCATTGGGTCCCTAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC017445 unedited ACGTCAGCCAACTTTGTAATACGAACCTCACTATAGTGGCGGCCCGCGTAATTCGCGCAC GAGGGCTTGCACTGGTCTGCTGAGAAGCTCAGGGGNAGCCAGGGNACAGGTTCCAAGACA AGGAAGGCAGTTGGGCTGTGGGAATGGGGAGCCCAGGGAAGGCCTCCAGAGCTGGCCTGG AGAGTCACCGCCGAGGGATTGAGGACGCGCCAGCCCGGGGGAACGCGCCAGCTGCTTTCG CGGCCCCAAGCGCGCAGTGCCCAGCAGCCGCGCCGAGCCTGACACGCTGTCCTCTCCCCT CGCGCACAGGGCTCTGCGAGTGACCCGGCGGGCGAGCTCCGTGCTGCATGGAACGGCTGC AGAAGCAACCACTTACCTCCCCCGGGAGCGTGAGCCCCTCCCGAGATTCCAGTGTGCCTG GCTCTCCCTCCAGCATCGTGGCCAAGATGGACAATCAGGTGCTGGGCTACAAGGACCTGG CTGCCATCCCCAAGGACAAGGCCATCCTGGACATCGAGCGGCCCGACCTCATGATCTACG AGCCTCACTTCACTTATTCCCTCCTGGAACACGTGGAGCTGCCTCGCAGCCGCGAGCGCT CGCTGTCACCCAAATCCACATCCCCCCCACCATCCCCAGAGGTGTGGGCGGACAGCCGGT CGCCTGGAATCATCTCTCAGGCCTCGGCCCCCAGAACCACTGGAACCCCCCGGACCAGCC TGCCCCATTTCCACCACCCTGAGACCTCCCGCCCAGATTCCAACATCTACAAGAAGCCTC CCATCTATAAGCAGAGAGAGTCCGTGGGAGGCAGCCCTCAGACCAAGCACCTCATCGAGG ATCTCATCATCGAGTCATCCAAGTTTTCTGCAGCCCAGCCCCCAGACCCCAACCAGCCAG CCAAAATCGAAACCGACTACTGGCCATGCCCCCCGTCTCTGGCTGTTGTGGAGACAGAAT GGAGAGCC
Restriction Sites	Please inquire
ACCN	BC017445
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC017445.1, AAH17445.1
RefSeq Size	2585 bp
Locus ID	2039
Gene Summary	The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]

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