APLP2 (BC004371) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	amyloid beta (A4) precursor-like protein 2; amyloid precursor protein homolog HSD-2; APPH; APPL2; CDEBP
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC004371 edited GCTAAGCGAGGAGTCTGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAG GGATGGCGGCCACCGGGACCGCGGCCGCCGCAGCCACGGGCAGGCTCCTGCTTCTGCTGC TGGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGCTACATCGAGGCTCTTGCAGCCA ATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAA ATATGCATGTGAACATTCAGACTGGGAAATGGGAACCTGATCCAACAGGCACCAAGAGCT GCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTATCCAGAGCTACAGA TCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACA AAAAGCAATGCAAGAGTCGCTTTGTTACACCTTTCAAGTGTCTCGTTCCTCCAACTCCTC TGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTC GCTTCCAGAAGGCTAAGGAGCAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAA AGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAAGCAGAGAGGCAGA CTCTGATTCAGCACTTCCAAGCCATGGTTAAAGCTTTAGAGAAGGAAGCAGCCAGTGAGA AGCAGCAGCTGGTGGAGACCCACCTGGCCCGAGTGGAAGCTATGCTGAATGACCGCCGTC GGATGGCTCTGGAGAACTACCTGGCTGCCTTGCAGTCTGACCCGCCACGGCCTCATCGCA TTCTCCAGGCCTTACGGCGTTATGTCCGTGCTGAGAACAAAGATCGCTTACATACCATCC GTCATTACCAGCACGTGTTGGCTGTTGACCCAGAAAAGGCGGCCCAGATGAAATCCCAGG TGATGACACATCTCCACGTGATTGAAGAAAGGAGGAACCAAACCCTCTCTCTGCTCTACA AAGTACCTTATGTAGCCCAAGAAATTCAAGAGGAAATTGATGAGCTCCTTCAGGAGCAGC GTGCAGATATGGACCAGTTCACTGCCTCAATCTCAGAGACCCCTGTGGACGTCCGGGTGA GCTCTGAGGAGAGTGAGGAGATCCCACCGTTCCACCCCTTCCACCCCTTCCCAGCCCTAC CTGAGAACGAAGGATCTGGAGTGGGAGAGCAGGATGGGGGACTGATCGGTGCCGAAGAGA AAGTGATTAACAGTAAGAATAAAGTGGATGAAAACATGGTCATTGACGAGACTCTGGATG TTAAGGAAATGATTTTCAATGCCGAGAGAGTTGGAGGCCTCGAGGAAGAGCGGGAATCCG TGGGCCCACTGCGGGAGGACTTCAGTCTGAGTAGCAGTGCTCTCATTGGCCTGCTGGTCA TCGCAGTGGCCATTGCCACGGTCATCGTCATCAGCCTGGTGATGCTGAGGAAGAGGCAGT ATGGCACCATCAGCCACGGGATCGTGGAGGTTGATCCAATGCTCACCCCAGAAGAGCGTC ACCTGAACAAGATGCAGAACCATGGCTATGAGAACCCCACCTACAAATACCTGGAGCAGA TGCAGATTTAGGTGGCAGGGAGCGCGGCAGCCCTGGCGGAGGGATGCAGGTGGGCCGGAA GATCCCACGATTCCGATCGACTGCCAAGCAGCAGCCGCTGCCAGGGGCTGCGTCTGACAT CCTGACCTCCTGGACTGTAGGACTATATAAAGTACTACTGTAGAACTGCAATTTCCATTC TTTTAAATGGGTGAAAAATGGTAATATAACAATATATGATATATAAAAAAAAAAAAAAAA AA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC004371 unedited GTTCAGATTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGGCTAAGCGAG GAGTCTGAGTGTGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCGGC CACCGGGACCGCGGCCGCCGCAGCCACGGGCAGGCTCCTGCTTCTGCTGCTGGTGGGGCT CACGGCGCCTGCCTTGGCGCTGGCCGGCTACATCGAGGCTCTTGCAGCCAATGCCGGAAC AGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCATGT GAACATTCAGACTGGGAAATGGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAAC AAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTATCCAGAGCTACAGATCACAAATGT GATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATG CAAGAGTCGCTTTGTTACACCTTTCAAGTGTCTCGTTCCTCCAACTCCTCTGCCAACCAA TGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCAGAA GGCTAAGGAGCAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATG GGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCAAAGCAGAGAGGCAGACTCTGATTCAG CACTTCCAAGCCATGGTTAAAGCTTTAGAGAAGGAAGCAGCCAGTGAGAAGCAGCAGCTG GTGGAGACCCANCTGGCCCGAGTGGAAGCTATGCTGAATGACCCCGCGTCGATGGCTCTG GAGAACTACCTGGCTGCCNTTGCAGTCTGACCGCCACGGCCTCATCGCATTCTNNCAGCC TTNACNGCGTAATGTCCGTGCTGAGAACAAAGATCGCTTACTTACATTCGTA
Restriction Sites	Please inquire
ACCN	BC004371
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC004371.1, AAH04371.1
RefSeq Size	1862 bp
RefSeq ORF	1566 bp
Locus ID	334
Protein Families	Druggable Genome, Transmembrane
Gene Summary	This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

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