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SIRT3 (NM_012239) Human Untagged Clone
CAT＃: SC127342
SIRT3 (untagged)-Human sirtuin 3 (SIRT3), nuclear gene encoding mitochondrial protein, transcript variant 1
CNY 3,656.00
| Cited in 4 publications. |
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热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | SIR2L3 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_012239 edited
CTCGGACTGCGCGGAACATGGCGTTCTGGGGTTGGCGCGCCGCGGCAGCCCTCCGGCTGT GGGGCCGGGTAGTTGAACGGGTCGAGGCCGGGGGAGGCGTGGGGCCGTTTCAGGCCTGCG GCTGTCGGCTGGTGCTTGGCGGCAGGGACGATGTGAGTGCGGGGCTGAGAGGCAGCCATG GGGCCCGCGGTGAGCCCTTGGACCCGGCGCGCCCCTTGCAGAGGCCTCCCAGACCCGAGG TGCCCAGGGCATTCCGGAGGCAGCCGAGGGCAGCAGCTCCCAGTTTCTTCTTTTCGAGTA TTAAAGGTGGAAGAAGGTCCATATCTTTTTCTGTGGGTGCTTCAAGTGTTGTTGGAAGTG GAGGCAGCAGTGACAAGGGGAAGCTTTCCCTGCAGGATGTAGCTGAGCTGATTCGGGCCA GAGCCTGCCAGAGGGTGGTGGTCATGGTGGGGGCCGGCATCAGCACACCCAGTGGCATTC CAGACTTCAGATCGCCGGGGAGTGGCCTGTACAGCAACCTCCAGCAGTACGATCTCCCGT ACCCCGAGGCCATTTTTGAACTCCCATTCTTCTTTCACAACCCCAAGCCCTTTTTCACTT TGGCCAAGGAGCTGTACCCTGGAAACTACAAGCCCAACGTCACTCACTACTTTCTCCGGC TGCTTCATGACAAGGGGCTGCTTCTGCGGCTCTACACGCAGAACATCGATGGGCTTGAGA GAGTGTCGGGCATCCCTGCCTCAAAGCTGGTTGAAGCTCATGGAACCTTTGCCTCTGCCA CCTGCACAGTCTGCCAAAGACCCTTCCCAGGGGAGGACATTCGGGCTGACGTGATGGCAG ACAGGGTTCCCCGCTGCCCGGTCTGCACCGGCGTTGTGAAGCCCGACATTGTGTTCTTTG GGGAGCCGCTGCCCCAGAGGTTCTTGCTGCATGTGGTTGATTTCCCCATGGCAGATCTGC TGCTCATCCTTGGGACCTCCCTGGAGGTGGAGCCTTTTGCCAGCTTGACCGAGGCCGTGC GGAGCTCAGTTCCCCGACTGCTCATCAACCGGGACTTGGTGGGGCCCTTGGCTTGGCATC CTCGCAGCAGGGACGTGGCCCAGCTGGGGGACGTGGTTCACGGCGTGGAAAGCCTAGTGG AGCTTCTGGGCTGGACAGAAGAGATGCGGGACCTTGTGCAGCGGGAAACTGGGAAGCTTG ATGGACCAGACAAATAGGATGATGGCTGCCCCCACACAATAAATGGTAACATAGGAGACA TCCACATCCCAATTCTGACAAGACCTCATGCCTGAAGACAGCTTGGGCAGGTGAAACCAG AATATGTGAACTGAGTGGACACCCGAGGCTGCCACTGGAATGTCTTCTCAGGCCATGAGC TGCAGTGACTGGTAGGGCTGTGTTTACAGTCAGGGCCACCCCGTCACATATACAAAGGAG CTGCCTGCCTGTTTGCTGTGTTGAACTCTTCACTCTGCTGAAGCTCCTAATGGAAAAAGC TTTCTTCTGACTGTGACCCTCTTGAACTGAATCAGACCAACTGGAATCCCAGACCGAGTC TGCTTTCTGTGCCTAGTTGAACGGCAAGCTCGGCATCTGTTGGTTACAAGATCCAGACTT GGGCCGAGCGGTCCCCAGCCCTCTTCATGTTCCGAAGTGTAGTCTTGAGGCCCTGGTGCC GCACTTCTAGCATGTTGGTCTCCTTTAGTGGGGCTATTTTTAATGAGAGAAAATCTGTTC TTTCCAGCATGAAATACATTTAGTCTCCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_012239 |
| Insert Size | 1800 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The insert of this clone has been fully sequenced and found to be a perfect match to NM_012239.4. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_012239.4, NP_036371.1 |
| RefSeq Size | 2900 bp |
| RefSeq ORF | 1200 bp |
| Locus ID | 23410 |
| UniProt ID | Q9NTG7 |
| Domains | SIR2 |
| Protein Families | Druggable Genome, Transcription Factors |
| Gene Summary | SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019] Transcript Variant: This variant (1) encodes isoform a. |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Neutrophil elastase-mediated proteolysis of the tumor suppressor p200 CUX1 promotes cell proliferation and inhibits cell differentiation in APL
,Yu, L;Zhong, L;Xiong, L;Dan, W;Li, J;Ye, J;Wan, P;Luo, X;Chu, X;Liu, C;He, C;Mu, F;Liu, B;,
Life Sci.
,PubMed ID 31887298
[SIRT3]
|
|
Mutant p53 induces SIRT3/MnSOD axis to moderate ROS production in melanoma cells
,Torrens-Mas, M;Cordani, M;Mullappilly, N;Pacchiana, R;Riganti, C;Palmieri, M;Pons, DG;Roca, P;Oliver, J;Donadelli, M;,
Arch. Biochem. Biophys.
,PubMed ID 31812668
[SIRT3]
|
|
Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival
,Pfleger, J;He, M;Abdellatif, M;,
Cell Death Dis
,PubMed ID 26225774
[SIRT3]
|
|
Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1a destabilization
,Wei, L;Zhou, Y;Qiao, C;Ni, T;Li, Z;You, Q;Guo, Q;Lu, N;,
Cell Death Dis
,PubMed ID 25855962
[SIRT3]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200190 | SIRT3 (Myc-DDK-tagged)-Human sirtuin 3 (SIRT3), nuclear gene encoding mitochondrial protein, transcript variant 1 |
CNY 5,488.00 |
|
| RC200190L1 | Lenti ORF clone of Human sirtuin 3 (SIRT3), nuclear gene encoding mitochondrial protein, transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC200190L2 | Lenti ORF clone of Human sirtuin 3 (SIRT3), nuclear gene encoding mitochondrial protein, transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC200190L3 | Lenti ORF clone of Human sirtuin 3 (SIRT3), nuclear gene encoding mitochondrial protein, transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC200190L4 | Lenti ORF clone of Human sirtuin 3 (SIRT3), nuclear gene encoding mitochondrial protein, transcript variant 1, mGFP tagged |
CNY 7,888.00 |
|
| RG200190 | SIRT3 (tGFP-tagged) - Human sirtuin 3 (SIRT3), nuclear gene encoding mitochondrial protein, transcript variant 1 |
CNY 7,088.00 |
|
| SC320624 | SIRT3 (untagged)-Human sirtuin 3 (SIRT3), nuclear gene encoding mitochondrial protein, transcript variant 1 |
CNY 3,656.00 |
