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CUG BP1 (CELF1) (NM_006560) Human Untagged Clone
CAT＃: SC128043
CELF1 (untagged)-Human CUGBP, Elav-like family member 1 (CELF1), transcript variant 1
CNY 3,656.00
| Cited in 5 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP; hNab50; NAB50; NAPOR |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC128043 sequence for NM_006560 edited (data generated by NextGen Sequencing)
ATGAACGGCACCCTGGACCACCCAGACCAACCAGATCTTGATGCTATCAAGATGTTTGTG GGCCAGGTTCCAAGGACCTGGTCTGAAAAGGACTTGCGGGAACTCTTCGAACAGTATGGT GCTGTGTATGAAATCAACGTCCTAAGGGATAGGAGCCAAAACCCGCCTCAGAGCAAAGGG TGCTGTTTTGTTACATTTTACACCCGTAAAGCTGCATTAGAAGCTCAGAATGCTCTTCAC AACATGAAAGTCCTCCCAGGGATGCATCACCCTATACAGATGAAACCTGCTGACAGTGAG AAGAACAATGCAGTGGAAGACAGGAAGCTGTTTATTGGTATGATTTCCAAGAAGTGCACT GAAAATGACATCCGAGTCATGTTCTCTTCGTTTGGACAGATTGAAGAATGCCGGATATTG CGGGGACCTGATGGCCTGAGCCGAGGTTGTGCATTTGTGACTTTTACAACAAGAGCCATG GCACAGACGGCTATCAAGGCAATGCACCAAGCACAGACCATGGAGGGTTGCTCATCACCC ATGGTGGTAAAATTTGCTGATACACAGAAGGACAAAGAACAGAAGAGAATGGCCCAGCAG CTCCAGCAGCAGATGCAGCAAATCAGCGCAGCATCTGTGTGGGGAAACCTTGCTGGTCTA AATACTCTTGGACCCCAGCATTTAGCACTCCTTCAGCAGACTGCCTCCTCTGGGAACCTC AACACCCTGAGCAGCCTCCACCCAATGGGAGGGTTGAATGCAATGCAGTTACAGAATTTG GCTGCACTAGCTGCTGCAGCTAGTGCAGCTCAGAACACACCAAGTGGTACCAATGCTCTC ACTACATCCAGCAGTCCCCTCAGCGTGCTCACTAGTTCAGGGTCCTCACCTAGCTCTAGC AGCAGTAATTCTGTCAACCCCATAGCCTCACTTGGAGCCCTGCAGACATTAGCTGGAGCA ACGGCTGGCCTCAATGTTGGCTCTTTGGCAGGAATGGCTGCTTTAAATGGTGGCCTGGGC AGCAGTGGCCTTTCCAATGGCACCGGGAGCACCATGGAGGCCCTCACTCAGGCCTACTCG GGTATCCAGCAATATGCTGCTGCTGCGCTCCCCACTCTGTACAACCAGAATCTTCTGACA CAGCAGAGTATTGGTGCTGCTGGAAGCCAGAAGGAAGGTCCAGAGGGAGCCAACCTGTTC ATCTACCACCTGCCCCAGGAGTTTGGTGATCAGGACCTGCTGCAGATGTTTATGCCCTTT GGGAATGTCGTGTCTGCCAAGGTTTTCATAGACAAGCAGACAAACCTGAGCAAGTGTTTT GGTTTTGTAAGTTACGACAATCCTGTTTCGGCCCAAGCTGCCATCCAGTCCATGAACGGC TTTCAGATTGGCATGAAGCGGCTTAAAGTGCAGCTCAAACGTTCGAAGAATGACAGCAAG CCCTACTGA Clone variation with respect to NM_006560.3 679 t=>c >OriGene 5' read for NM_006560 unedited
GTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCTGGCGGCAGCGGCAGC GGCGGCGGGACGCGGAGGCTCCCCCGGGATTCGGCCTCAGCAGCGAGGCGGCGGCGGCGG CTGCGGAGGCGCAGGCAGCAACTGAGGCAGCGGCAGGCTCAGGTGCAGCCGCTGGCTGGA GTGCAGTGGTGTGTTCTCAGCTCTGCAGCCCCCGCTTCCCAGGTTCAAGTAACTGCCTCA GCCTTCTGAGTAGCTGGGATTACAGGTGTGCACCACCACGCCCAGGCTGAACATAACTTC TTTTTTTCAAAGTTCCCTGTGTTGTGAACTGAGCTTGGGTGAAGTGAAATCTTTGAGGAA GCTAAAGCTGTGTGTATTTGTGGATCAGACAAGTGCAGCAAGTTAATATCATTGGCTTCT GAAGGGGAGAGTGAGGTGATGGCTGCGTTTAAGTTGGATTTCCTTCCAGAAATGATGGTG GATCATTGCTCTTTGAATTCCAGTCCCGTCTCAAAGAAAATGAACGGCACCCTGGACCAC CCAGACCAACCAGATCTTGATGCTATCAAGATGTTTGTGGGCCAGGTTCCAAGGACCTGG TCTGAAAAGGACTTGCGGGAACTCTTCGAACAGTATGGTGCTGTGTATGAAATCAACGTC CTAAGGGATAGGAGCCAAAACCCGCCTCAGACANAGGGTGCTGTTTTGTTACATTTTACA NCCCGTAAGCTGCATTAGAAGCTCAGAATGCTCTTCACACATGAAAGTCCTCCCAGGATG CATCACCCTATACAGATGANACCTGCTGACAGTGAGAAGAACAATGCAGTGGNAAGACAG AAAGCTGTTNATTGGTATGANTTCCCAGAAGTGCACTGANAATGACATNNCGAGTCATGT CTCTTCGTTNGGAANNGATGAANAATGCCGNATATTTGCGGGACCTGATGGCCTC >OriGene 3' genomic read for NM_006560 unedited
GTACCGCGGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTATTTTTATTTTTTG CATTTATTTAAAAAATCCCATCATGACCCTGGAAGCCTTTAGAACAGTTTTATCCTTTGA AACACAGGACACATTTCTCCCAGTGCGCAGAATTTCAAGTTTACGTGGTTCAGCTTAAGA AGTGTATGTTTCACGTTCCTTAGAGGACAACAGACCCAAGTTATCACTATGAGAAAGGAA CAGCTGTCCCAGCTTCAATGGGATAATCCAACACCACCAGCTACCTGTACAACAGTAAGA TGGTCAATCCCTGTCTGTTACCCACAGGGACAGCATGACAAGGAGAGAGCCCCCATCTGA CTTAATAGCAAACCAACCCCTTTATTCTTATCTCTGCTGCTAGGGGTCAAGACTGGTATT TGTTGAGGTTTCAGATTCCAGAGACCCAGGGATCCCATCCCCTGGCTGTGGCTACAGTCA CATCTTAACAGGGCCACCTCTGCCCAGGTGTACATTCCCAACAGCATGTCCTTCCTGGTT CTCTACCCCCACAGCACTTCTTAGAGCACAGGCCGAGCCCACAAGCTGTGTGGGTCACAG GCAAGAGCTGAAGTAAGACCTGCAAGAGGCGGCAGGGAGCTAACTGTACCACGAGCACAA AACGACCCGGTTATACTGAGGTAAACGAACACTCACTTCATGCGGAGGCTGGCAACGCCC TGATGTTCCCTCTGCCTCAGAGCAAACAAGGGATTGGAGTGTTTCCGGAAGGCCCTGCCA CACCCCTGGGGAAATCTACTCTGGGCACCTAATTAACGAGGCAGGGAAACCTCTGGCACT GGCACCGACCCTCTGGTTCGCCGGACCCTCGGTTAAGTCCCCAAAAAAACCCCCCCTCCC CATACAGGTTCGGCCCCTCCCCCAACGCCCCG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_006560 |
| Insert Size | 3780 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_006560.2, NP_006551.1 |
| RefSeq Size | 2157 bp |
| RefSeq ORF | 1449 bp |
| Locus ID | 10658 |
| UniProt ID | Q92879 |
| Domains | RRM |
| Protein Families | Druggable Genome |
| Gene Summary | Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) is the predominant transcript and it encodes isoform 1. |
Citations (5)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition
,Yan, JK;Zhang, T;Dai, LN;Gu, BL;Zhu, J;Yan, WH;Cai, W;Wang, Y;,
FASEB J.
,PubMed ID 30514107
[CELF1]
|
|
Overexpression of miR-214-3p in esophageal squamous cancer cells enhances sensitivity to cisplatin by targeting survivin directly and indirectly through CUG-BP1
,Phatak, P;Byrnes, KA;Mansour, D;Liu, L;Cao, S;Li, R;Rao, JN;Turner, DJ;Wang, JY;Donahue, JM;,
Oncogene
,PubMed ID 26234674
[CELF1]
|
|
Competition between RNA-binding proteins CELF1 and HuR modulates MYC translation and intestinal epithelium renewal
,Liu, L;Ouyang, M;Rao, JN;Zou, T;Xiao, L;Chung, HK;Wu, J;Donahue, JM;Gorospe, M;Wang, JY;,
Mol. Biol. Cell
,PubMed ID 25808495
[CELF1]
|
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Jnk2 Deletion Disrupts Intestinal Mucosal Homeostasis and Maturation by Differentially Modulating RNA-binding Proteins HuR and CUGBP1
,Chung, HK;Rao, JN;Zou, T;Liu, L;Xiao, L;Gu, H;Turner, DJ;Yang, P;Wang, JY;,
Am. J. Physiol., Cell Physiol. April 2014
,PubMed ID 24740539
[CELF1]
|
|
Competitive binding of CUGBP1 and HuR to occludin mRNA controls its translation and modulates epithelial barrier function
,Ting-Xi Yu, Jaladanki N. Rao, Tongtong Zou, Lan Liu, Lan Xiao, Miao Ouyang, Shan Cao, Myriam Gorospe, and Jian-Ying Wang,
Mol. Biol. Cell, Jan 2013; 24: 85 - 99.
[CELF1]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC206275 | CELF1 (Myc-DDK-tagged)-Human CUGBP, Elav-like family member 1 (CELF1), transcript variant 1 |
CNY 3,656.00 |
|
| RC206275L1 | Lenti ORF clone of Human CUGBP, Elav-like family member 1 (CELF1), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC206275L2 | Lenti ORF clone of Human CUGBP, Elav-like family member 1 (CELF1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC206275L3 | Lenti ORF clone of Human CUGBP, Elav-like family member 1 (CELF1), transcript variant 1, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC206275L4 | Lenti ORF clone of Human CUGBP, Elav-like family member 1 (CELF1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG206275 | CELF1 (tGFP-tagged) - Human CUGBP, Elav-like family member 1 (CELF1), transcript variant 1 |
CNY 5,256.00 |
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