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IREB2 (NM_004136) Human Untagged Clone
CAT＃: SC128101
IREB2 (untagged)-Human iron-responsive element binding protein 2 (IREB2)
CNY 7,064.00
CNY 7,220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ACO3; IRE-BP 2; IRE-BP2; IRP2; IRP2AD; NDCAMA |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC128101 sequence for NM_004136 edited (data generated by NextGen Sequencing)
ATGGACGCCCCAAAAGCAGGATACGCCTTTGAGTACCTTATTGAAACATTAAATGACAGT TCACATAAGAAGTTCTTCGATGTATCTAAACTTGGCACCAAGTATGATGTTCTGCCTTAC TCAATACGGGTCTTGTTGGAAGCTGCTGTACGAAATTGTGATGGCTTTTTAATGAAGAAG GAAGATGTTATGAACATTTTAGACTGGAAAACCAAACAAAGCAATGTTGAAGTGCCCTTT TTCCCTGCCCGTGTTCTTCTTCAAGATTTTACTGGAATACCAGCAATGGTGGATTTTGCT GCTATGAGGGAGGCAGTGAAAACTCTTGGAGGTGATCCTGAGAAAGTCCATCCTGCTTGT CCGACAGATCTTACAGTTGACCATTCTTTACAAATTGACTTCAGTAAATGTGCAATACAG AATGCACCAAATCCTGGAGGTGGTGACCTGCAGAAAGCAGGAAAGCTCTCTCCACTTAAA GTGCAGCCTAAGAAGCTTCCCTGCAGAGGCCAGACTACCTGCCGAGGATCTTGTGATTCT GGAGAACTAGGCCGAAACTCAGGAACATTTTCTTCGCAGATTGAGAATACACCCATCCTG TGTCCTTTTCATTTGCAACCAGTGCCTGAACCTGAAACAGTGTTAAAAAATCAAGAAGTA GAATTCGGCAGAAATCGAGAGAGGCTTCAGTTTTTTAAGTGGAGTTCAAGAGTTTTTAAG AATGTGGCAGTGATCCCTCCTGGAACTGGAATGGCTCATCAAATAAACTTAGAATATTTG TCAAGAGTGGTTTTTGAAGAAAAAGACCTCCTCTTCCCAGACAGTGTAGTCGGCACAGAT TCACACATAACGATGGTGAATGGTTTAGGGATTCTGGGGTGGGGGGTTGGAGGCATTGAA ACAGAAGCAGTTATGCTTGGTCTGCCAGTTTCTCTTACTTTACCAGAGGTGGTTGGATGT GAGTTAACTGGGTCATCAAACCCTTTTGTTACATCCATAGATGTTGTTCTTGGTATTACA AAGCACCTCAGGCAAGTAGGAGTGGCTGGAAAGTTTGTTGAGTTTTTTGGAAGTGGAGTT TCACAATTATCTATAGTTGATCGAACTACAATAGCAAACATGTGTCCGGAATATGGTGCT ATCCTCAGCTTTTTCCCTGTTGACAATGTGACATTAAAACATTTAGAACATACAGGTTTT AGCAAAGCCAAACTCGAATCAATGGAAACATACCTTAAAGCTGTGAAATTGTTTCGAAAT GACCAGAATTCTTCAGGAGAACCTGAATACTCCCAGGTGATCCAGATTAATCTGAATTCA ATAGTTCCATCTGTTAGTGGTCCAAAAAGACCTCAGGATAGAGTTGCTGTGACAGATATG AAAAGCGATTTCCAGGCTTGCTTAAATGAAAAGGTTGGATTTAAAGGCTTCCAAATTGCA GCTGAAAAACAAAAGGATATTGTCTCCATTCATTATGAAGGAAGTGAATATAAGCTGTCT CATGGATCAGTGGTCATTGCTGCAGTTATCAGTTGTACCAATAATTGCAATCCATCTGTC ATGCTTGCTGCAGGTCTTTTGGCTAAAAAGGCTGTTGAAGCTGGTCTGCGTGTTAAACCT TATATAAGAACAAGTTTATCTCCAGGCAGTGGGATGGTTACACATTACCTCAGTTCAAGT GGAGTATTACCATATCTAAGTAAGCTTGGATTTGAAATCGTTGGCTATGGATGTTCAACT TGTGTGGGAAATACAGCACCCTTATCAGACGCAGTTTTAAATGCAGTAAAACAGGGTGAT TTGGTTACCTGTGGAATTTTATCTGGAAACAAAAATTTTGAAGGTCGTCTTTGTGATTGT GTTCGTGCCAATTATCTTGCCTCTCCACCCTTAGTGGTAGCTTATGCCATAGCAGGCACA GTGAATATAGATTTCCAGACAGAACCTTTAGGTACTGACCCCACCGGCAAGAACATTTAC CTGCATGATATTTGGCCTAGTCGAGAAGAAGTTCATCGAGTAGAGGAAGAACATGTTATA CTATCCATGTTTAAAGCATTAAAAGATAAAATAGAAATGGGGAATAAACGGTGGAATTCC TTAGAAGCACCGGATTCAGTTTTGTTTCCATGGGACTTAAAGTCTACTTATATCAGATGC CCTTCATTTTTTGATAAACTTACCAAAGAGCCAATTGCACTCCAGGCTATTGAAAATGCC CATGTCTTATTATATTTGGGAGACTCTGTCACAACAGATCATATATCACCTGCAGGAAGT ATCGCTAGGAATAGTGCTGCCGCTAAGTATTTGACAAACAGAGGCCTTACCCCTCGTGAA TTCAACTCTTACGGAGCTCGAAGAGGTAATGATGCTGTAATGACAAGAGGCACTTTTGCA AATATCAAGCTTTTTAATAAGTTTATTGGAAAACCAGCTCCTAAAACAATTCATTTTCCA TCAGGACAGACGCTAGATGTATTTGAGGCTGCAGAGCTGTACCAGAAAGAAGGTATCCCA CTGATTATTTTAGCAGGAAAGAAATATGGTTCAGGAAACTCCAGAGACTGGGCTGCCAAA GGACCGTATTTACTGGGTGTGAAAGCTGTTTTGGCTGAAAGTTATGAAAAAATACACAAA GATCATTTGATTGGAATTGGCATAGCTCCACTTCAGTTCCTTCCAGGAGAAAATGCAGAT TCCTTGGGCCTCTCCGGTAGAGAAACATTTTCTTTAACATTTCCTGAAGAACTGTCTCCT GGAATTACATTGAATATACAGACAAGCACTGGAAAAGTATTCAGCGTGATTGCTTCGTTT GAAGATGATGTGGAAATAACATTATACAAACATGGAGGATTATTAAACTTTGTGGCACGA AAATTCTCATAG Clone variation with respect to NM_004136.2 2616 c=>t >OriGene 5' read for NM_004136 unedited
CAATTCCCCCGCCCGTTGCCGCATTGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAA GCAGAGTTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCG CGAATTCGGCACGAGGCCCTTCTTCCCCCGCTGGCCCCCTCCCCGGAGGGATAATATGGT CTCCGGCGATGGACGCCCCAAAAGCAGGATACGCCTTTGAGTACCTTATTGAAACATTAA ATGACAGTTCACATAAGAAGTTCTTCGATGTATCTAAACTTGGCACCAAGTATGATGTTC TGCCTTACTCAATACGGGTCTTGTTGGAAGCTGCTGTACGAAATTGTGATGGCTTTTTAA TGAAGAAGGAAGATGTTATGAACATTTTAGACTGGAAAACCAAACAAAGCAATGTTGAAG TGCCCTTTTTCCCTGCCCGTGTTCTTCTTCAAGAGTTTACTGGAATACCAGCAATGGTGG ATTTTGCTGCTATGAGGGAGGCAGTGAAAACTCTTGGAGGTGATCCTGAGAAAGTCCATC CTGCTTGTCCGACAGATCTTACAGTTGACCATTCTTTACAAATTGACTTCAGTAAATGTG CAATACAGAATGCACCAAATCCTGGAGGTGGTGACCTGCAGAAAGCAGGAAAGCTCTCTC CACTTAAAGTGCAGCCTAAGAAGCTTCCCTGCAGAGGCCAGACTACCTGCCGAGGATCTT GTGATTCTGGAGACTAGGCCGAAACTCAGGACATTTTCTTCGCAGATTGAGAGACACCCA TNCTGTGTCCTTTTCATTTGCAACCAGTGCCCTGACCTGAAACAGTGTTAAANCATCAAG AAGTAGTATTCTGCTGACATCGAGAGAGGCTTCAGTTNTTTCAAGTGGAGTTCAAGACGT TTTCGAGTGTGGCAGTGATCCTTCTGNAAACTGCATGGCTCATCCAATAACTTAGATAAT TGTCA >OriGene 3' genomic read for NM_004136 unedited
TAGGATCGAGTTTTTTTTTTTTTTTTTTGGTAACACAAAATTACCCAAGGTATAGTAAAC AAAGAAGACACAGACAATAAAAACTAACAGATGCCACATTTTGCAAACATAGCATTTGGC TAGAGGCAGAATTATAAGGTATACATATTAAAACATACATCCNAGACTCTCCTCCTCAAT TTGAACCAATGTTATCAAGTTTTACTTCATGNNTATAGCCAAAAAAATTAGAGAACTTGA TTTGTCCTGAAATCAGAATTGCTTGATTATTACTGACCAGTNAACTGGAATGGGAAGTTT AATCAAAGTTGCCAGGTTTACACCACCCCCGAAAACCTGCGGGGAGACCGTGGGCCGGCC CAAAAAATTATAAAGATGCTTTTAAAAACATAGCCGCCGGTGGGGGCCCACCCGGATCCC ACCTTTGGGGGCCCAGGGGGGGGTTCCAGGGCGAGAAATTTTATTTGGCGCCCCGGGGAA ACCCCCCCTCCAAAAAACAAAAAAAAATGGGCGGGGGGGGCACCCCTTTTCCCCCCCCCC CGGAGGGGGGGGGGGGGAACCCCCCCCCCCCGGGGCGGGGTTTTTTTAAAAAAAAATACC CTTTTTTTTCCCCCCCCCCCGGGGGAACAACCCTCTAAAAAAAACCACCCAAATTTTTTT TTTTCCCCCCCAACAGGGGGAAAATTTTTTTTAAAAAAACAAAGGGTTTTTTCTTCTCCG GGTGTTTCCCCCCAACGGTTTTGGAGGAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004136 |
| Insert Size | 4700 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004136.1, NP_004127.1 |
| RefSeq Size | 3928 bp |
| RefSeq ORF | 2892 bp |
| Locus ID | 3658 |
| UniProt ID | P48200 |
| Protein Families | Druggable Genome |
| Gene Summary | The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221385 | IREB2 (Myc-DDK-tagged)-Human iron-responsive element binding protein 2 (IREB2) |
CNY 7,056.00 |
|
| RC221385L1 | Lenti ORF clone of Human iron-responsive element binding protein 2 (IREB2), Myc-DDK-tagged |
CNY 9,456.00 |
|
| RC221385L2 | Lenti ORF clone of Human iron-responsive element binding protein 2 (IREB2), mGFP tagged |
CNY 9,030.00 |
|
| RC221385L3 | Lenti ORF clone of Human iron-responsive element binding protein 2 (IREB2), Myc-DDK-tagged |
CNY 9,030.00 |
|
| RC221385L4 | Lenti ORF clone of Human iron-responsive element binding protein 2 (IREB2), mGFP tagged |
CNY 9,456.00 |
|
| RG221385 | IREB2 (tGFP-tagged) - Human iron-responsive element binding protein 2 (IREB2) |
CNY 8,656.00 |
