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PAX2 (NM_000278) Human Untagged Clone
CAT＃: SC300041
PAX2 (untagged)-Human paired box 2 (PAX2), transcript variant b
CNY 3,656.00
CNY 6,370.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | FSGS7; PAPRS |
| Vector | PCMV6-Neo |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene ORF within SC300041 sequence for NM_000278 edited (data generated by NextGen Sequencing)
ATGGATATGCACTGCAAAGCAGACCCCTTCTCCGCGATGCACCNNNGGCACGGGGGTGTG AACCAGCTCGGGGGGGTGTTTGTGAACGGCCGGCCCCTACCCGACGTGGTGAGGCAGCGC ATCGTGGAGCTGGCCCACCAGGGTGTGCGGCCCTGTGACATCTCCCGGCAGCTGCGGGTC AGCCACGGCTGTGTCAGCAAAATCCTGGGCAGGTACTACGAGACCGGCAGCATCAAGCCG GGTGTGATCGGTGGCTCCAAGCCCAAAGTGGCGACGCCCAAAGTGGTGGACAAGATTGCT GAATACAAACGACAGAACCCGACTATGTTCGCCTGGGAGATTCGAGACCGGCTCCTGGCC GAGGGCATCTGTGACAATGACACAGTGCCCAGCGTCTCTTCCATCAACAGAATCATCCGG ACCAAAGTTCAGCAGCCTTTCCACCCAACGCCGGATGGGGCTGGGACAGGAGTGACCGCC CCTGGCCACACCATTGTTCCCAGCACGGCCTCCCCTCCTGTTTCCAGCGCCTCCAATGAC CCAGTGGGATCCTACTCCATCAATGGGATCCTGGGGATTCCTCGCTCCAATGGTGAGAAG AGGAAACGTGATGAAGATGTGTCTGAGGGCTCAGTCCCCAATGGAGATTCCCAGAGTGGT GTGGACAGTTTGCGGAAGCACTTGCGAGCTGACACCTTCACCCAGCAGCAGCTGGAAGCT TTGGATCGGGTCTTTGAGCGTCCTTCCTACCCTGACGTCTTCCAGGCATCAGAGCACATC AAATCAGAACAGGGGAACGAGTACTCCCTCCCAGCCCTGACCCCTGGGCTTGATGAAGTC AAGTCGAGTCTATCTGCATCCACCAACCCTGAGCTGGGCAGCAACGTGTCAGGCACACAG ACATACCCAGTTGTGACTGGTCGTGACATGGCGAGCACCACTCTGCCTGGTTACCCCCCT CACGTGCCCCCCACTGGCCAGGGAAGCTACCCCACCTCCACCCTGGCAGGAATGGTGCCT GGGAGCGAGTTCTCCGGCAACCCGTACAGCCACCCCCAGTACACGGCCTACAACGAGGCT TGGAGATTCAGCAACCCCGCCTTACTAAGTTCCCCTTATTATTATAGTGCCGCCCCCCGG TCCGCCCCTGCCGCTGCTGCCGCTGCCTATGACCGCCACTAG Clone variation with respect to NM_000278.3 44 c=>n;45 a=>n;46 g=>n |
| Restriction Sites | Please inquire |
| ACCN | NM_000278 |
| Insert Size | 1300 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to differ from the protein associated to this reference by three amino acids. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000278.2, NP_000269.2 |
| RefSeq Size | 4207 bp |
| RefSeq ORF | 1182 bp |
| Locus ID | 5076 |
| UniProt ID | Q02962 |
| Protein Families | Druggable Genome |
| Gene Summary | PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014] Transcript Variant: This variant (b) lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant e. This results in a protein (isoform b) with a shorter, distinct C-terminus compared to isoform e. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. CCDS Note: The coding region has been updated to add an additional glycine residue in the protein C-terminal region, supported by the available transcript and conservation data. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations
,Hart, MR;Anderson, DJ;Porter, CC;Neff, T;Levin, M;Horwitz, MS;,
PLoS Genet.
,PubMed ID 30216339
[PAX2]
|
|
DNA methylation promotes paired box 2 expression via myeloid zinc finger 1 in endometrial cancer
,Jia, N;Wang, J;Li, Q;Tao, X;Chang, K;Hua, K;Yu, Y;Wong, KK;Feng, W;,
Oncotarget
,PubMed ID 27764784
[PAX2]
|
Documents
| Product Manuals |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC212112 | PAX2 (Myc-DDK-tagged)-Human paired box 2 (PAX2), transcript variant b |
CNY 3,656.00 |
|
| RC212112L1 | Lenti ORF clone of Human paired box 2 (PAX2), transcript variant b, Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC212112L2 | Lenti ORF clone of Human paired box 2 (PAX2), transcript variant b, mGFP tagged |
CNY 5,890.00 |
|
| RC212112L3 | Lenti ORF clone of Human paired box 2 (PAX2), transcript variant b, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC212112L4 | Lenti ORF clone of Human paired box 2 (PAX2), transcript variant b, mGFP tagged |
CNY 5,890.00 |
|
| RG212112 | PAX2 (tGFP-tagged) - Human paired box 2 (PAX2), transcript variant b |
CNY 5,256.00 |
