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WRN (NM_000553) Human Untagged Clone
CAT＃: SC300096
WRN (untagged)-Human Werner syndrome, RecQ helicase-like (WRN)
CNY 27,550.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | RECQ3; RECQL2; RECQL3 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_000553, the custom clone sequence may differ by one or more nucleotides
ATGAGTGAAAAAAAATTGGAAACAACTGCACAGCAGCGGAAATGTCCTGAATGGATGAAT GTGCAGAATAAAAGATGTGCTGTAGAAGAAAGAAAGGCATGTGTTCGGAAGAGTGTTTTT GAAGATGACCTCCCCTTCTTAGAATTCACTGGATCCATTGTGTATAGTTACGATGCTAGT GATTGCTCTTTCCTGTCAGAAGATATTAGCATGAGTCTATCAGATGGGGATGTGGTGGGA TTTGACATGGAGTGGCCACCATTATACAATAGAGGGAAACTTGGCAAAGTTGCACTAATT CAGTTGTGTGTTTCTGAGAGCAAATGTTACTTGTTCCACGTTTCTTCCATGTCAGTTTTT CCCCAGGGATTAAAAATGTTGCTTGAAAATAAAGCAGTTAAAAAGGCAGGTGTAGGAATT GAAGGAGATCAGTGGAAACTTCTACGTGACTTTGATATCAAATTGAAGAATTTTGTGGAG TTGACAGATGTTGCCAATAAAAAGCTGAAATGCACAGAGACCTGGAGCCTTAACAGTCTG GTTAAACACCTCTTAGGTAAACAGCTCCTGAAAGACAAGTCTATCCGCTGTAGCAATTGG AGTAAATTTCCTCTCACTGAGGACCAGAAACTGTATGCAGCCACTGATGCTTATGCTGGT TTTATTATTTACCGAAATTTAGAGATTTTGGATGATACTGTGCAAAGGTTTGCTATAAAT AAAGAGGAAGAAATCCTACTTAGCGACATGAACAAACAGTTGACTTCAATCTCTGAGGAA GTGATGGATCTGGCTAAGCATCTTCCTCATGCTTTCAGTAAATTGGAAAACCCACGGAGG GTTTCTATCTTACTAAAGGATATTTCAGAAAATCTATATTCACTGAGGAGGATGATAATT GGGTCTACTAACATTGAGACTGAACTGAGGCCCAGCAATAATTTAAACTTATTATCCTTT GAAGATTCAACTACTGGGGGAGTACAACAGAAACAAATTAGAGAACATGAAGTTTTAATT CACGTTGAAGATGAAACATGGGACCCAACACTTGATCATTTAGCTAAACATGATGGAGAA GATGTACTTGGAAATAAAGTGGAACGAAAAGAAGATGGATTTGAAGATGGAGTAGAAGAC AACAAATTGAAAGAGAATATGGAAAGAGCTTGTTTGATGTCGTTAGATATTACAGAACAT GAACTCCAAATTTTGGAACAGCAGTCTCAGGAAGAATATCTTAGTGATATTGCTTATAAA TCTACTGAGCATTTATCTCCCAATGATAATGAAAACGATACGTCCTATGTAATTGAGAGT GATGAAGATTTAGAAATGGAGATGCTTAAGCATTTATCTCCCAATGATAATGAAAACGAT ACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGTCTTTAGAA AACCTCAATAGTGGCACGGTAGAACCAACTCATTCTAAATGCTTAAAAATGGAAAGAAAT CTGGGTCTTCCTACTAAAGAAGAAGAAGAAGATGATGAAAATGAAGCTAATGAAGGGGAA GAAGATGATGATAAGGACTTTTTGTGGCCAGCACCCAATGAAGAGCAAGTTACTTGCCTC AAGATGTACTTTGGCCATTCCAGTTTTAAACCAGTTCAGTGGAAAGTGATTCATTCAGTA TTAGAAGAAAGAAGAGATAATGTTGCTGTCATGGCAACTGGATATGGAAAGAGTTTGTGC TTCCAGTATCCACCTGTTTATGTAGGCAAGATTGGCCTTGTTATCTCTCCCCTTATTTCT CTGATGGAAGACCAAGTGCTACAGCTTAAAATGTCCAACATCCCAGCTTGCTTCCTTGGA TCAGCACAGTCAGAAAATGTTCTAACAGATATTAAATTAGGTAAATACCGGATTGTATAC GTAACTCCAGAATACTGTTCAGGTAACATGGGCCTGCTCCAGCAACTTGAGGCTGATATT GGTATCACGCTCATTGCTGTGGATGAGGCTCACTGTATTTCTGAGTGGGGGCATGATTTT AGGGATTCATTCAGGAAGTTGGGCTCCCTAAAGACAGCACTGCCAATGGTTCCAATCGTT GCACTTACTGCTACTGCAAGTTCTTCAATCCGGGAAGACATTGTACGTTGCTTAAATCTG AGAAATCCTCAGATCACCTGTACTGGTTTTGATCGACCAAACCTGTATTTAGAAGTTAGG CGAAAAACAGGGAATATCCTTCAGGATCTGCAGCCATTTCTTGTCAAAACAAGTTCCCAC TGGGAATTTGAAGGTCCAACAATCATCTACTGTCCTTCTAGAAAAATGACACAACAAGTT ACAGGTGAACTTAGGAAACTGAATCTATCCTGTGGAACATACCATGCGGGCATGAGTTTT AGCACAAGGAAAGACATTCATCATAGGTTTGTAAGAGATGAAATTCAGTGTGTCATAGCT ACCATAGCTTTTGGAATGGGCATTAATAAAGCTGACATTCGCCAAGTCATTCATTACGGT GCTCCTAAGGACATGGAATCATATTATCAGGAGATTGGTAGAGCTGGTCGTGATGGACTT CAAAGTTCTTGTCACGTCCTCTGGGCTCCTGCAGACATTAACTTAAATAGGCACCTTCTT ACTGAGATACGTAATGAGAAGTTTCGATTATACAAATTAAAGATGATGGCAAAGATGGAA AAATATCTTCATTCTAGCAGATGTAGGAGACAAATCATCTTGTCTCATTTTGAGGACAAA CAAGTACAAAAAGCCTCCTTGGGAATTATGGGAACTGAAAAATGCTGTGATAATTGCAGG TCCAGATTGGATCATTGCTATTCCATGGATGACTCAGAGGATACATCCTGGGACTTTGGT CCACAAGCATTTAAGCTTTTGTCTGCTGTGGACATCTTAGGCGAAAAATTTGGAATTGGG CTTCCAATTTTATTTCTCCGAGGATCTAATTCTCAGCGTCTTGCCGATCAATATCGCAGG CACAGTTTATTTGGCACTGGCAAGGATCAAACAGAGAGTTGGTGGAAGGCTTTTTCCCGT CAGCTGATCACTGAGGGATTCTTGGTAGAAGTTTCTCGGTATAACAAATTTATGAAGATT TGCGCCCTTACGAAAAAGGGTAGAAATTGGCTTCATAAAGCTAATACAGAATCTCAGAGC CTCATCCTTCAAGCTAATGAAGAATTGTGTCCAAAGAAGTTGCTTCTGCCTAGTTCGAAA ACTGTATCTTCGGGCACCAAAGAGCATTGTTATAATCAAGTACCAGTTGAATTAAGTACA GAGAAGAAGTCTAACTTGGAGAAGTTATATTCTTATAAACCATGTGATAAGATTTCTTCT GGGAGTAACATTTCTAAAAAAAGTATCATGGTACAGTCACCAGAAAAAGCTTACAGTTCC TCACAGCCTGTTATTTCGGCACAAGAGCAGGAGACTCAGATTGTGTTATATGGCAAATTG GTAGAAGCTAGGCAGAAACATGCCAATAAAATGGATGTTCCCCCAGCTATTCTGGCAACA AACAAGATACTGGTGGATATGGCCAAAATGAGACCAACTACGGTTGAAAACGTAAAAAGG ATTGATGGTGTTTCTGAAGGCAAAGCTGCCATGTTGGCCCCTCTGTTGGAAGTCATCAAA CATTTCTGCCAAACAAATAGTGTTCAGACAGACCTCTTTTCAAGTACAAAACCTCAAGAA GAACAGAAGACGAGTCTGGTAGCAAAAAATAAAATATGCACACTTTCACAGTCTATGGCC ATCACATACTCTTTATTCCAAGAAAAGAAGATGCCTTTGAAGAGCATAGCTGAGAGCAGG ATTCTGCCTCTCATGACAATTGGCATGCACTTATCCCAAGCGGTGAAAGCTGGCTGCCCC CTTGATTTGGAGCGAGCAGGCCTGACTCCAGAGGTTCAGAAGATTATTGCTGATGTTATC CGAAACCCTCCCGTCAACTCAGATATGAGTAAAATTAGCCTAATCAGAATGTTAGTTCCT GAAAACATTGACACGTACCTTATCCACATGGCAATTGAGATCCTTAAACATGGTCCTGAC AGCGGACTTCAACCTTCATGTGATGTCAACAAAAGGAGATGTTTTCCCGGTTCTGAAGAG ATCTGTTCAAGTTCTAAGAGAAGCAAGGAAGAAGTAGGCATCAATACTGAGACTTCATCT GCAGAGAGAAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCAGCAAGAAA TTAATGGACAAAACGAAAAGGGGAGGTCTTTTTAGTTAA |
| Restriction Sites | Please inquire |
| ACCN | NM_000553 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_000553.2, NP_000544.1 |
| RefSeq Size | 5765 bp |
| RefSeq ORF | 4299 bp |
| Locus ID | 7486 |
| UniProt ID | Q14191 |
| Protein Families | Druggable Genome, Stem cell - Pluripotency |
| Gene Summary | This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC222919 | WRN (Myc-DDK-tagged)-Human Werner syndrome, RecQ helicase-like (WRN) |
CNY 14,696.00 |
|
| RC222919L1 | Lenti-ORF clone of WRN (Myc-DDK-tagged)-Human Werner syndrome, RecQ helicase-like (WRN) |
CNY 16,150.00 |
|
| RC222919L2 | Lenti-ORF clone of WRN (mGFP-tagged)-Human Werner syndrome, RecQ helicase-like (WRN) |
CNY 16,150.00 |
|
| RC222919L3 | Lenti-ORF clone of WRN (Myc-DDK-tagged)-Human Werner syndrome, RecQ helicase-like (WRN) |
CNY 17,096.00 |
|
| RC222919L4 | Lenti-ORF clone of WRN (mGFP-tagged)-Human Werner syndrome, RecQ helicase-like (WRN) |
CNY 16,150.00 |
|
| RG222919 | WRN (tGFP-tagged) - Human Werner syndrome, RecQ helicase-like (WRN) |
CNY 15,680.00 |
