United States
Germany
Japan
United Kingdom
China
IFIT3 (NM_001031683) Human Untagged Clone
CAT＃: SC302530
IFIT3 (untagged)-Human interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 2
CNY 3,656.00
CNY 7,220.00
Product images
CNY 1,999.00
CNY 2,700.00
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CIG-49; cig41; GARG-49; IFI60; IFIT4; IRG2; ISG60; P60; RIG-G |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_001031683 edited
GCTTGGAATCAGTAAGCTAAAAACAAAATCAACCGGGACCCCAGCTTTTCAGAACTGCAG GGAAACAGCCATCATGAGTGAGGTCACCAAGAATTCCCTGGAGAAAATCCTTCCACAGCT GAAATGCCATTTCACCTGGAACTTATTCAAGGAAGACAGTGTCTCAAGGGATCTAGAAGA TAGAGTGTGTAACCAGATTGAATTTTTAAACACTGAGTTCAAAGCTACAATGTACAACTT GTTGGCCTACATAAAACACCTAGATGGTAACAACGAGGCAGCCCTGGAATGCTTACGGCA AGCTGAAGAGTTAATCCAGCAAGAACATGCTGACCAAGCAGAAATCAGAAGTCTAGTCAC TTGGGGAAACTACGCCTGGGTCTACTATCACTTGGGCAGACTCTCAGATGCTCAGATTTA TGTAGATAAGGTGAAACAAACCTGCAAGAAATTTTCAAATCCATACAGTATTGAGTATTC TGAACTTGACTGTGAGGAAGGGTGGACACAACTGAAGTGTGGAAGAAATGAAAGGGCGAA GGTGTGTTTTGAGAAGGCTCTGGAAGAAAAGCCCAACAACCCAGAATTCTCCTCTGGACT GGCAATTGCGATGTACCATCTGGATAATCACCCAGAGAAACAGTTCTCTACTGATGTTTT GAAGCAGGCCATTGAGCTGAGTCCTGATAACCAATACGTCAAGGTTCTCTTGGGCCTGAA ACTGCAGAAGATGAATAAAGAAGCTGAAGGAGAGCAGTTTGTTGAAGAAGCCTTGGAAAA GTCTCCTTGCCAAACAGATGTCCTCCGCAGTGCAGCCAAATTTTACAGAAGAAAAGGTGA CCTAGACAAAGCTATTGAACTGTTTCAACGGGTGTTGGAATCCACACCAAACAATGGCTA CCTCTATCACCAGATTGGGTGCTGCTACAAGGCAAAAGTAAGACAAATGCAGAATACAGG AGAATCTGAAGCTAGTGGAAATAAAGAGATGATTGAAGCACTAAAGCAATATGCTATGGA CTATTCGAATAAAGCTCTTGAGAAGGGACTGAATCCTCTGAATGCATACTCCGATCTCGC TGAGTTCCTGGAGACGGAATGTTATCAGACACCATTCAATAAGGAAGTCCCTGATGCTGA AAAGCAACAATCCCATCAGCGCTACTGCAACCTTCAGAAATATAATGGGAAGTCTGAAGA CACTGCTGTGCAACATGGTTTAGAGGGTTTGTCCATAAGCAAAAAATCAACTGACAAGGA AGAGATCAAAGACCAACCACAGAATGTATCTGAAAATCTGCTTCCACAAAATGCACCAAA TTATTGGTATCTTCAAGGATTAATTCATAAGCAGAATGGAGATCTGCTGCAAGCAGCCAA ATGTTATGAGAAGGAACTGGGCCGCCTGCTAAGGGATGCCCCTTCAGGCATAGGCAGTAT TTTCCTGTCAGCATCTGAGCTTGAGGATGGTAGTGAGGAAATGGGCCAGGGCGCAGTCAG CTCCAGTCCCAGAGAGCTCCTCTCTAACTCAGAGCAACTGAACTGAGACAGAGGAGGAAA ACAGAGCATCAGAAGCCTGCAGTGGTGGTTGTGACGGGTAGGACGATAGGAAGACAGGGG GCCCCAACCTGGGATTGCTGAGCAGGGAAGCTTTGCATGTTGCTCTAAGGTACATTTTTA AAGAGTTGTTTTTTGGCCGGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGG CCGAGGTGGGCGGATCACGAGGTCTGGAGTTTGAGACCATCCTGGCTAACACAGTGAAAT CCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCTGGCACCTGTAGTCCC AGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGAAGGAAGAGGTTGCAGAG AGCCAAGATTGCGCCCCTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAA AAAAAAAAAAAAAAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001031683 |
| Insert Size | 2000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The ORF of this clone has been fully sequenced and found to be a perfect match to NM_001031683.1. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001031683.1, NP_001026853.1 |
| RefSeq Size | 1999 bp |
| RefSeq ORF | 1473 bp |
| Locus ID | 3437 |
| UniProt ID | O14879 |
| Gene Summary | IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. Variants 1 and 2 both encode isoform a, using different start codons but encoding identical proteins. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC214701 | IFIT3 (Myc-DDK-tagged)-Human interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 2 |
CNY 3,656.00 |
|
| RC214701L3 | Lenti ORF clone of Human interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC214701L4 | Lenti ORF clone of Human interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG214701 | IFIT3 (tGFP-tagged) - Human interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), transcript variant 2 |
CNY 5,256.00 |
