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beta Arrestin 1 (ARRB1) (NM_004041) Human Untagged Clone
CAT＃: SC303424
ARRB1 (untagged)-Human arrestin, beta 1 (ARRB1), transcript variant 1
CNY 5,488.00
| Cited in 4 publications. |
Product images
CNY 1,999.00
CNY 3,600.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ARB1; ARR1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_004041 edited
CCGCGCTCCTCCTGCTGGCTGGGGATTTTCCAGCCTGGGCGCTGACGCCGCGGACCTCCC TGCGACCGTCGCGGACCATGGGCGACAAAGGGACCCGAGTGTTCAAGAAGGCCAGTCCAA ATGGAAAGCTCACCGTCTACCTGGGAAAGCGGGACTTTGTGGACCACATCGACCTCGTGG ACCCTGTGGATGGTGTGGTCCTGGTGGATCCTGAGTATCTCAAAGAGCGGAGAGTCTATG TGACGCTGACCTGCGCCTTCCGCTATGGCCGGGAGGACCTGGATGTCCTGGGCCTGACCT TTCGCAAGGACCTGTTTGTGGCCAACGTACAGTCGTTCCCACCGGCCCCCGAGGACAAGA AGCCCCTGACGCGGCTGCAGGAACGCCTCATCAAGAAGCTGGGCGAGCACGCTTACCCTT TCACCTTTGAGATCCCTCCAAACCTTCCATGTTCTGTGACACTGCAGCCGGGGCCCGAAG ACACGGGGAAGGCTTGCGGTGTGGACTATGAAGTCAAAGCCTTCTGCGCGGAGAATTTGG AGGAGAAGATCCACAAGCGGAATTCTGTGCGTCTGGTCATCCGGAAGGTTCAGTATGCCC CAGAGAGGCCTGGCCCCCAGCCCACAGCCGAGACCACCAGGCAGTTCCTCATGTCGGACA AGCCCTTGCACCTAGAAGCCTCTCTGGATAAGGAGATCTATTACCATGGAGAACCCATCA GCGTCAACGTCCACGTCACCAACAACACCAACAAGACGGTGAAGAAGATCAAGATCTCAG TGCGCCAGTATGCAGACATCTGCCTTTTCAACACAGCTCAGTACAAGTGCCCTGTTGCCA TGGAAGAGGCTGATGACACTGTGGCACCCAGCTCGACGTTCTGCAAGGTCTACACACTGA CCCCCTTCCTAGCCAATAACCGAGAGAAGCGGGGCCTCGCCTTGGACGGGAAGCTCAAGC ACGAAGACACGAACTTGGCCTCTAGCACCCTGTTGAGGGAAGGTGCCAACCGTGAGATCC TGGGGATCATTGTTTCCTACAAAGTGAAAGTGAAGCTGGTGGTGTCTCGGGGCGGCCTGT TGGGAGATCTTGCATCCAGCGACGTGGCCGTGGAACTGCCCTTCACCCTAATGCACCCCA AGCCCAAAGAGGAACCCCCGCATCGGGAAGTTCCAGAGAACGAGACGCCAGTAGATACCA ATCTCATAGAACTTGACACAAATGATGACGACATTGTATTTGAGGACTTTGCTCGCCAGA GACTGAAAGGCATGAAGGATGACAAGGAGGAAGAGGAGGATGGTACCGGCTCTCCACAGC TCAACAACAGATAGACGGGCCGGCCCTGCCTCCACGTGGCTCCGGCTCCACTCTCGTGCA CTCGGATGCTTACTCGTCTTCTTCCTGTTCTGGTTTCTTTTCCCCTTTGTTCTTCCAGTT TCTACCAGGGGGCCCCGTGGGCTTCCAGATCACGGTGATGAACCTCTGGCCTCAGGATTG GCCCCACATCACCACGCCAACAGGACCACAGCGCACTGGCTCCACCCCATCTCTGCCATC TCCACTCCCCTCCTTTTCATGCTGTCTCCCAGAAAAGCTGCCAGGGCTCTGGCCTTGGAA TTGGACTTGAGATGGGGAGCAGACAGGGGAGGATGGGGAATGTGGGACACGGTGTGGTGG GCATGAGGGCTTGGAGGGGTGGGGATGAGGGCTCAAGACACGAGAGAAGATGTCCACGGT CCCAGGTGGTTAACAAAGTTCTGGCAGCTAAAAGATGACCGCGTTGAAGGCCACCTCCTT CTGGCTGGGAGGGGCAGAACTGTGGACAGATTCTCAATGCCTTTTTGAAGTTCTGACCCA CCAAAGACCTTCTGCCTTCACCCTCCTCCCCACCTGATGTCCCTCTGTGTCTGATAGTGA TGTTGGTGAAAGTTCGTAGACCCCAGGAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_004041 |
| Insert Size | 2000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | ORF matches to NM_004041.3. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004041.3, NP_004032.2 |
| RefSeq Size | 2204 bp |
| RefSeq ORF | 1257 bp |
| Locus ID | 408 |
| UniProt ID | P49407 |
| Protein Families | Druggable Genome |
| Protein Pathways | Chemokine signaling pathway, Endocytosis, MAPK signaling pathway |
| Gene Summary | Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011] Transcript Variant: This variant (1) represents the longer transcript variant and encodes the longer isoform (A). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
ARRB1 Regulates Metabolic Reprogramming to Promote Glycolysis in Stem Cell-Like Bladder Cancer Cells
,Mamouni, K;Kim, J;Lokeshwar, B;Kallifatidis, G;,
Cancers
,PubMed ID 33920080
[ARRB1]
|
|
Overexpression of β-Arrestins inhibits proliferation and motility in triple negative breast cancer cells
,Bostanabad, SY;Noyan, S;Dedeoglu, BG;Gurdal, H;,
Scientific reports
,PubMed ID 33452359
[ARRB1]
|
|
Beta2 Adrenergic Receptor Fluorescent Protein Fusions Traffic to the Plasma Membrane and Retain Functionality
,Bubnell, J;Pfister, P;Sapar, ML;Rogers, ME;Feinstein, P;,
PLoS One. 2013 Sep 23;8(9):e74941
,PubMed ID 24086401
[ARRB1]
|
|
Oxyntomodulin differentially affects Glucagon-Like Peptide-1 receptor beta-arrestin recruitment and signaling through G-alpha-s
,Rasmus Jorgensen, Valentina Kubale, Milka Vrecl, Thue W Schwartz, and Christian E Elling,
J Pharmacol Exp Ther. 2007 Jul;322(1):148-54.
[ARRB1]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC201279 | ARRB1 (Myc-DDK-tagged)-Human arrestin, beta 1 (ARRB1), transcript variant 1 |
CNY 5,488.00 |
|
| RC201279L1 | Lenti ORF clone of Human arrestin, beta 1 (ARRB1), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC201279L2 | Lenti ORF clone of Human arrestin, beta 1 (ARRB1), transcript variant 1, mGFP tagged |
CNY 7,888.00 |
|
| RC201279L3 | Lenti ORF clone of Human arrestin, beta 1 (ARRB1), transcript variant 1, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC201279L4 | Lenti ORF clone of Human arrestin, beta 1 (ARRB1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG201279 | ARRB1 (tGFP-tagged) - Human arrestin, beta 1 (ARRB1), transcript variant 1 |
CNY 7,088.00 |
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