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INAVA (NM_018265) Human Untagged Clone
CAT＃: SC304571
C1orf106 (untagged)-Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1
CNY 10,640.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C1orf106 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>SC304571 representing NM_018265.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGCCCCAGGGGACAGATGTCTTGGGATCTTTAACATTTGGGATGCTGCAAATGCCGAAGTTAAATGAA ATACCTCCGGGGAGGGCAGGCCGCAGGGAGGCTCGGGGGGAGGGAAGATGGCCTGGACAAACAGGTCCT GAAGCTGCGAGGCTGGAGTGGAGGGCGCAGGGGCAGGCGGGCGGCGCCAGAGCTCCATGGGACAGCTGG GGAAGCTCCAGGCTACCTACACAACCTGGCCCAGGCTGGTCACGGTGTCCCCCCTCCCTGCTCTGTGCC CTCTCCTTCCAGAAATCCACCATGGAGAGTAAGGATGAGGTCAGCGACACCGACAGTGGCATCATCCTG CAGTCTGGCCCCGACAGCCCGGTCTCCCCAATGAAGGAGCTGACCCATGCAGTGCACAAGCAGCAGAGG GCCCTGGAAGCGAGGCTGGAGGCCTGCCTGGAGGAGCTGAGGAGACTCTGCCTTCGGGAAGCGGAGCTG ACGGGCACCTTGCCAGCGGAGTATCCCCTCAAACCAGGGGAAAAGGCCCCCAAGGTTCGCCGCAGGATC GGAGCGGCTTACAAACTGGATGACTGGGCCTTGCACAGAGAGGACCCCCTAAGCAGCCTGGAGCGCCAG CTGGCCCTGCAGCTGCAGATCACAGAGGCAGCCCGTCGGCTGTGCCTGGAGGAGAACCTCAGCAGGCAG GCTCGGCGGCAGCGGAAGCACTCCATGCTGCAGGAGGAGAAGAAGCTGCAGGAGCTCCAGCGCTGCCTG GTCGAGCGGCGGCGCAATAGCGAGCCACCTCCGGCTGCTGCTCTCCCCCTGGGCCGAGAGCTCAGTGCC TCTGATGACAGCTCCCTGTCAGATGGGCTCCTCCTGGAGGAAGAGGAATCCCAAGTGCCAAAACCTCCT CCAGAGTCTCCAGCCCCACCTTCTCGGCCTCTCCCACCCCAAACCCTTGAGGGTCTGCAGCCAACAGGA CCTGAGGCTGGGAGCCCAGAACGGGCTCCAGTCCAGAACAGCCCCTGGAAGGAAACCAGCCTGGACCAC CCCTATGAGAAGCCCAGGAAGTCTTCTGAGCCCTGGAGCGAGTCCAGCAGCCCAGCCACCACACCACAG GATGGGCCCAGTGCCTCCAGCCTGTGGCTTCTGGAGCCTGCCTCCTACCACGTGGTTCCCATCCGTGGT GTTCCTGGCCAGTGGCAGGGCCGCACCAGTGCCCCAGCCACCCCTGAGATACAGGGGAGGAGGGGCCAG TCGCAGTCTCTGAGGGTGGATTCCTTCCGGGCGGGTCCTGAGGGCCGAGGTCGCAGCGCCTTTCCCCGC CGCCGCCCCACTCACTACACGGTGACAGTGCCAGATTCCTGCTTTCCCGCGACCAAGCCCCCGCTGCCC CACGCCGCCTGCCACTCCTGCTCAGAAGACAGTGGCTCTGACGTCTCCAGCATCTCCCACCCCACTTCG CCGGGCAGCAGCAGCCCCGACATCTCCTTTCTGCAGCCTCTCTCCCCTCCCAAGACCCATCGTCACCGC GGGGCCTGGGTCCCAGCCGGCAGCAGAGAGCTGGTCGCCCACCACCCCAAGCTACTGCTGCCGCCTGGC TATTTCCCGGCGGGGCGGTACGTGGTGGTGGCTGAGAGCCCCCTGCCGCCTGGCGAGTGGGAGCTGCGC CGCGCAGCCCCGGGCCCTGCTTACGAGGAGGAGGGCACTCCCCTGCGCTACCAGCGTCTGGTGCCCTCC CGCAGCCGCATCGTGCGGACGCCCTCCCTGAAGGACAGCCCGGCAGGCCGGGGGCTCAGCAAGGCCGCC GTGTCCGAGGAGCTCAAGTGGTGGCACGAGCGTGCACGCCTCCGGAGCACCCGCCCCCACTCACTGGAC CGCCAAGGAGCTTTCCGGGTCAGGAGCCTGCCCCTTGGGAGAGAGGGCTTCGGACGAGCCCTGGGACCC CGGGCACAGGTGCCCACAGTTTGTGTGCTGCGGAGATCGCCTGATGGGGCCCCTGTGCAAGTCTTTGTA CCTGAAAAAGGAGAGATCATCAGCCAGGTGTAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_018265 |
| Insert Size | 2034 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_018265.3 |
| RefSeq Size | 4161 bp |
| RefSeq ORF | 2034 bp |
| Locus ID | 55765 |
| UniProt ID | Q3KP66 |
| MW | 74.3 kDa |
| Gene Summary | Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC215863 | C1orf106 (Myc-DDK-tagged)-Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1 |
CNY 7,400.00 |
|
| RC215863L1 | Lenti ORF clone of Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1, Myc-DDK-tagged |
CNY 9,800.00 |
|
| RC215863L2 | Lenti ORF clone of Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1, mGFP tagged |
CNY 6,460.00 |
|
| RC215863L3 | Lenti ORF clone of Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1, Myc-DDK-tagged |
CNY 6,460.00 |
|
| RC215863L4 | Lenti ORF clone of Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1, mGFP tagged |
CNY 6,460.00 |
|
| RG215863 | C1orf106 (tGFP-tagged) - Human chromosome 1 open reading frame 106 (C1orf106), transcript variant 1 |
CNY 9,000.00 |
