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CACNA1E (NM_000721) Human Untagged Clone
CAT＃: SC309052
CACNA1E (untagged)-Human calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E), transcript variant 3
CNY 43,700.00
货期*
12周
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BII; CACH6; CACNL1A6; Cav2.3; DEE69; EIEE69; gm139 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>SC309052 representing NM_000721.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGCTCGCTTCGGGGAGGCGGTGGTCGCCAGGCCAGGGTCCGGCGATGGAGACTCGGACCAGAGCAGG AACCGGCAAGGAACCCCCGTGCCGGCCTCGGGGCAGGCGGCCGCCTACAAGCAGACGAAAGCACAGAGG GCGCGGACTATGGCTTTGTACAACCCCATTCCCGTCCGGCAGAACTGTTTCACCGTCAACAGATCCCTG TTCATCTTCGGAGAAGATAACATTGTCAGGAAATATGCCAAGAAGCTCATCGATTGGCCGCCATTTGAG TACATGATCCTGGCCACCATCATTGCCAACTGCATCGTCCTGGCCCTGGAGCAGCATCTTCCTGAGGAT GACAAGACCCCCATGTCCCGAAGACTGGAGAAGACAGAACCTTATTTCATTGGGATCTTTTGCTTTGAA GCTGGGATCAAAATTGTGGCCCTGGGGTTCATCTTCCATAAGGGCTCTTACCTCCGCAATGGCTGGAAT GTCATGGACTTCATCGTGGTCCTCAGTGGCATCCTGGCCACTGCAGGAACCCACTTCAATACTCACGTG GACCTGAGGACCCTCCGGGCTGTGCGTGTCCTGCGGCCTTTGAAGCTCGTGTCAGGGATACCTAGCCTG CAGATTGTGTTGAAGTCCATCATGAAGGCCATGGTACCTCTTCTGCAGATTGGCCTTCTGCTCTTCTTT GCCATCCTGATGTTTGCTATCATTGGTTTGGAGTTCTACAGTGGCAAGTTACATCGAGCATGCTTCATG AACAATTCAGGTATTCTAGAAGGATTTGACCCCCCTCACCCATGTGGTGTGCAGGGCTGCCCAGCTGGT TATGAATGCAAGGACTGGATCGGCCCCAATGATGGGATCACCCAGTTTGATAACATCCTTTTTGCTGTG CTGACTGTCTTCCAGTGCATCACCATGGAAGGGTGGACCACTGTGCTGTACAATACCAATGATGCCTTA GGAGCCACCTGGAATTGGCTGTACTTCATCCCCCTCATCATCATTGGATCCTTCTTTGTTCTCAACCTA GTCCTGGGAGTGCTTTCCGGGGAATTTGCCAAAGAGAGAGAGAGAGTGGAGAACCGAAGGGCTTTCATG AAGCTGCGGCGCCAGCAGCAGATTGAGCGTGAGCTGAATGGCTACCGTGCCTGGATAGACAAAGCAGAG GAAGTCATGCTCGCTGAAGAAAATAAAAATGCTGGAACATCCGCCTTAGAAGTGCTTCGAAGGGCAACC ATCAAGAGGAGCCGGACAGAGGCCATGACTCGAGACTCCAGTGATGAGCACTGTGTTGATATCTCCTCT GTGGGCACACCTCTGGCCCGAGCCAGTATCAAAAGTGCAAAGGTAGACGGGGTCTCTTATTTCCGGCAC AAGGAAAGGCTTCTGCGCATCTCCATTCGCCACATGGTTAAATCCCAGGTGTTTTACTGGATTGTGCTG AGCCTTGTGGCACTCAACACTGCCTGTGTGGCCATTGTCCATCACAACCAGCCCCAGTGGCTCACCCAC CTCCTCTACTATGCAGAATTTCTGTTTCTGGGACTCTTCCTCTTGGAGATGTCCCTGAAGATGTATGGC ATGGGGCCTCGCCTTTATTTTCACTCTTCATTCAACTGCTTTGATTTTGGGGTCACAGTGGGCAGTATC TTTGAAGTGGTCTGGGCAATCTTCAGACCTGGTACGTCTTTTGGAATCAGTGTCTTGCGAGCCCTCCGG CTTCTAAGAATATTTAAAATAACCAAGTATTGGGCTTCCCTACGGAATTTGGTGGTCTCCTTGATGAGC TCAATGAAGTCTATCATCAGTTTGCTTTTCCTCCTCTTCCTCTTCATCGTTGTCTTTGCTCTCCTAGGA ATGCAGTTATTTGGAGGCAGGTTTAACTTTAATGATGGGACTCCTTCGGCAAATTTTGATACCTTCCCT GCAGCCATCATGACTGTGTTCCAGATCCTGACGGGTGAGGACTGGAATGAGGTGATGTACAATGGGATC CGCTCCCAGGGTGGGGTCAGCTCAGGCATGTGGTCTGCCATCTACTTCATTGTGCTCACCTTGTTTGGC AACTACACGCTACTGAATGTGTTCTTGGCTATCGCTGTGGATAATCTCGCCAACGCCCAGGAACTGACC AAGGATGAACAGGAGGAAGAAGAGGCCTTCAACCAGAAACATGCACTGCAGAAGGCCAAGGAGGTCAGC CCGATGTCTGCACCCAACATGCCTTCGATCGAAAGAGACAGAAGGAGAAGACACCACATGTCGATGTGG GAGCCACGCAGCAGCCACCTGAGGGAGCGGAGGCGCCGGCACCACATGTCCGTGTGGGAGCAGCGTACC AGCCAGCTGAGGAAGCACATGCAGATGTCCAGCCAGGAGGCCCTCAACAGAGAGGAGGCGCCGACCATG AACCCGCTCAACCCCCTCAACCCGCTCAGCTCCCTCAACCCGCTCAATGCCCACCCCAGCCTTTATCGG CGACCCAGGGCCATTGAGGGCCTGGCCCTGGGCCTGGCCCTGGAGAAGTTCGAGGAGGAGCGCATCAGC CGTGGGGGGTCCCTCAAGGGGGATGGAGGGGACCGATCCAGTGCCCTGGACAACCAGAGGACCCCTTTG TCCCTGGGCCAGCGGGAGCCACCATGGCTGGCCAGGCCCTGTCATGGAAACTGTGACCCGACTCAGCAG GAGGCAGGGGGAGGAGAGGCTGTGGTGACCTTTGAGGACCGGGCCAGGCACAGGCAGAGCCAACGGCGC AGCCGGCATCGCCGCGTCAGGACAGAAGGCAAGGAGTCCTCTTCAGCCTCCCGGAGCAGGTCTGCCAGC CAGGAACGCAGTCTGGATGAAGCCATGCCCACTGAAGGGGAGAAGGACCATGAGCTCAGGGGCAACCAT GGTGCCAAGGAGCCAACGATCCAAGAAGAGAGAGCCCAGGATTTAAGGAGGACCAACAGTCTGATGGTG TCCAGAGGCTCCGGGCTGGCAGGAGGCCTTGATGAGGCTGACACCCCCCTAGTCCTGCCCCATCCTGAG CTGGAAGTGGGGAAGCACGTGGTGCTGACGGAGCAGGAGCCAGAAGGCAGCAGTGAGCAGGCCCTGCTG GGGAATGTGCAGCTAGACATGGGCCGGGTCATCAGCCAGAGCGAGCCTGACCTCTCCTGCATCACGGCC AACACGGACAAGGCCACCACCGAGAGCACCAGCGTCACCGTCGCCATCCCCGACGTGGACCCCTTGGTG GACTCAACCGTGGTGCACATTAGCAACAAGACGGATGGGGAAGCCAGTCCCTTGAAGGAGGCAGAGATC AGAGAGGATGAGGAGGAGGTGGAGAAGAAGAAGCAGAAGAAGGAGAAGCGTGAGACAGGCAAAGCCATG GTGCCCCACAGCTCAATGTTCATCTTCAGCACCACCAACCCGATCCGGAGGGCCTGCCACTACATCGTG AACCTGCGCTACTTTGAGATGTGCATCCTCCTGGTGATTGCAGCCAGCAGCATCGCCCTGGCGGCAGAG GACCCCGTCCTGACCAACTCGGAGCGCAACAAAGTCCTGAGGTATTTTGACTATGTGTTCACGGGCGTG TTCACCTTTGAGATGGTTATAAAGATGATAGACCAAGGCTTGATCCTGCAGGATGGGTCCTACTTCCGA GACTTGTGGAACATCCTGGACTTTGTGGTGGTCGTTGGCGCATTGGTGGCCTTTGCTCTGGCGAACGCT TTGGGAACCAACAAAGGACGGGACATCAAGACCATCAAGTCTCTGCGGGTGCTCCGAGTTCTAAGGCCA CTGAAAACCATCAAGCGCTTGCCCAAGCTCAAGGCCGTCTTCGACTGCGTAGTGACCTCCTTGAAGAAT GTCTTCAACATACTCATTGTGTACAAGCTCTTCATGTTCATCTTTGCTGTCATCGCAGTTCAGCTCTTC AAGGGAAAGTTCTTTTATTGCACGGACAGTTCCAAGGACACAGAGAAGGAGTGCATAGGCAACTATGTA GATCATGAGAAAAACAAGATGGAGGTGAAGGGCCGGGAATGGAAGCGCCATGAATTCCACTACGACAAC ATTATCTGGGCCCTGCTGACCCTCTTCACCGTCTCCACAGGGGAAGGATGGCCTCAAGTTCTGCAGCAC TCTGTAGATGTGACAGAGGAAGACCGAGGCCCAAGCCGCAGCAACCGCATGGAGATGTCTATCTTTTAT GTAGTCTACTTTGTGGTCTTCCCCTTCTTCTTTGTCAATATCTTTGTGGCTCTCATCATCATCACCTTC CAGGAGCAAGGGGATAAGATGATGGAGGAGTGCAGCCTGGAGAAGAATGAGAGGGCGTGCATCGACTTC GCCATCAGCGCCAAACCTCTCACCCGCTACATGCCGCAGAACAGACACACCTTCCAGTACCGCGTGTGG CACTTTGTGGTGTCTCCGTCCTTTGAGTACACCATTATGGCCATGATCGCCTTGAATACTGTTGTGCTG ATGATGAAGTATTATTCTGCTCCCTGTACCTATGAGCTGGCCCTGAAGTACCTGAATATCGCCTTCACC ATGGTGTTTTCCCTGGAATGTGTCCTGAAGGTCATCGCTTTTGGCTTTTTGAACTATTTCCGAGACACC TGGAATATCTTTGACTTCATCACCGTGATTGGCAGTATCACAGAAATTATCCTGACAGACAGCAAGCTG GTGAACACCAGTGGCTTCAATATGAGCTTTCTGAAGCTCTTCCGAGCTGCCCGCCTCATAAAGCTCCTG CGTCAGGGCTATACCATACGCATTTTGCTGTGGACCTTTGTGCAGTCCTTTAAGGCCCTCCCTTATGTC TGCCTTTTAATTGCCATGCTTTTCTTCATTTATGCCATCATTGGGATGCAGGTATTTGGAAACATAAAA TTAGACGAGGAGAGTCACATCAACCGGCACAACAACTTCCGGAGTTTCTTTGGGTCCCTAATGCTACTC TTCAGGAGTGCCACAGGTGAGGCCTGGCAGGAGATTATGCTGTCATGCCTTGGGGAGAAGGGCTGTGAG CCTGACACCACCGCACCATCAGGGCAGAACGAGAACGAACGCTGCGGCACCGATCTGGCCTACGTGTAC TTTGTCTCCTTCATCTTCTTCTGCTCCTTCTTGATGCTCAACCTGTTTGTGGCCGTCATCATGGACAAC TTTGAGTACCTGACTCGGGACTCCTCCATCCTGGGGCCTCACCACTTGGACGAGTTTGTCCGCGTCTGG GCAGAATATGACCGAGCAGCATGTGGCCGCATCCATTACACTGAGATGTATGAAATGCTGACTCTCATG TCACCTCCGCTAGGCCTCGGCAAGAGATGTCCCTCCAAAGTGGCATATAAGAGGTTGGTCCTGATGAAC ATGCCAGTAGCTGAGGACATGACGGTCCACTTCACCTCCACACTTATGGCTCTGATCCGGACAGCTCTG GACATTAAAATTGCCAAAGGTGGTGCAGACAGGCAGCAGCTAGACTCAGAGCTACAAAAGGAGACCCTA GCCATCTGGCCTCACCTATCCCAGAAGATGCTGGATCTGCTTGTGCCCATGCCCAAAGCCTCTGACCTG ACTGTGGGCAAAATCTATGCAGCAATGATGATCATGGACTACTATAAGCAGAGTAAGGTGAAGAAGCAG AGGCAGCAGCTGGAGGAACAGAAAAATGCCCCCATGTTCCAGCGCATGGAGCCTTCATCTCTGCCTCAG GAGATCATTGCTAATGCCAAAGCCCTGCCTTACCTCCAGCAGGACCCCGTTTCAGGCCTGAGTGGCCGG AGTGGATACCCTTCGATGAGTCCACTCTCTCCCCAGGATATATTCCAGTTGGCTTGTATGGACCCCGCC GATGACGGACAGTTCCAAGAACGGCAGTCTCTGGTGGTGACAGACCCTAGCTCCATGAGACGTTCATTT TCCACTATTCGGGATAAGCGTTCAAATTCCTCGTGGTTGGAGGAATTCTCCATGGAGCGAAGCAGTGAA AATACCTACAAGTCCCGTCGCCGGAGTTACCACTCCTCCTTGCGGCTGTCAGCCCACCGCCTGAACTCT GATTCAGGCCACAAGTCTGACACTCACCGCTCAGGGGGCAGGGAGCGGGGACGATCAAAAGAGCGAAAG CATCTTCTCTCTCCTGATGTCTCCCGCTGCAATTCAGAAGAGCGAGGGACCCAGGCTGACTGGGAGTCC CCAGAGCGCCGTCAATCCAGGTCACCCAGTGAGGGCAGGTCACAGACGCCCAACAGACAGGGCACAGGT TCCCTAAGTGAGAGCTCCATCCCCTCTGTCTCTGACACCAGCACCCCAAGAAGAAGTCGTCGGCAGCTC CCACCCGTCCCGCCAAAGCCCCGGCCCCTCCTTTCCTACAGCTCCCTGATTCGACACGCGGGCAGCATC TCTCCACCTGCTGATGGAAGCGAGGAGGGCTCCCCGCTGACCTCCCAAGCTCTGGAGAGCAACAATGCT TGCCTGACCGAGTCTTCCAACTCTCCGCACCCCCAGCAGAGCCAACATGCCTCCCCACAGCGCTACATC TCCGAGCCCTACTTGGCCCTGCACGAAGACTCCCACGCCTCAGACTGTGGTGAGGAGGAGACGCTCACT TTCGAAGCAGCCGTGGCTACTAGCCTGGGCCGTTCCAACACCATCGGCTCAGCCCCACCCCTGCGGCAT AGCTGGCAGATGCCCAACGGGCACTATCGGCGGCGGAGGCGCGGGGGGCCTGGGCCAGGCATGATGTGT GGGGCTGTCAACAACCTGCTAAGTGACACGGAAGAAGATGACAAATGCTAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_000721 |
| Insert Size | 6813 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000721.3 |
| RefSeq Size | 14972 bp |
| RefSeq ORF | 6813 bp |
| Locus ID | 777 |
| UniProt ID | Q15878 |
| Domains | ion_trans |
| Protein Families | Druggable Genome, Ion Channels: Calcium, Transmembrane |
| Protein Pathways | Calcium signaling pathway, MAPK signaling pathway, Type II diabetes mellitus |
| MW | 257.1 kDa |
| Gene Summary | Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] Transcript Variant: This variant (3) is missing an in-frame coding exon compared to variant 1. This results in a shorter isoform (3, also known as alpha-1E-3) missing an internal protein segment compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Resources
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| SKU | Description | Size | Price |
|---|---|---|---|
| RC221733 | CACNA1E (Myc-DDK-tagged)-Human calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E), transcript variant 3 |
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| RC221733L1 | Lenti ORF clone of Human calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E), transcript variant 3, Myc-DDK-tagged |
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| RG221733 | CACNA1E (tGFP-tagged) - Human calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E), transcript variant 3 |
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