United States
Germany
Japan
United Kingdom
China
JAK3 (NM_000215) Human Untagged Clone
CAT＃: SC311134
JAK3 (untagged)-Human Janus kinase 3 (JAK3)
CNY 11,752.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000215 edited
CCGGGATCCCGGCTCTGCCCGCCCTTCGAAAGTCCAGGGTCCCCGCCCGCTAGGACTGAG GGGCTTTTTCTCTCTGTGCCCCAGGCAAGTTGCACTCATGGCACCTCCAAGTGAAGAGAC GCCCCTGATCCCTCAGCGTTCATGCAGCCTCTTGTCCACGGAGGCTGGTGCCCTGCATGT GCTGCTGCCCGCTCGGGGCCCCGGGCCCCCCCAGCGCCTATCTTTCTCCTTTGGGGACCA CTTGGCTGAGGACCTGTGCGTGCAGGCTGCCAAGGCCAGCGGCATCCTGCCTGTGTACCA CTCCCTCTTTGCTCTGGCCACGGAGGACCTGTCCTGCTGGTTCCCCCCGAGCCACATCTT CTCCGTGGAGGATGCCAGCACCCAAGTCCTGCTGTACAGGATTCGCTTTTACTTCCCCAA TTGGTTTGGGCTGGAGAAGTGCCACCGCTTCGGGCTACGCAAGGATTTGGCCAGTGCTAT CCTTGACCTGCCAGTCCTGGAGCACCTCTTTGCCCAGCACCGCAGTGACCTGGTGAGTGG GCGCCTCCCCGTGGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTT GGACCTGGCCCGGATGGCGCGAGAGCAGGCCCAGCGGCCGGGAGAGCTGCTGAAGACTGT CAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGT GACGCGGAGGCGTATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCA GGCAGACCGGCACTCGCTCATGGCCAAGTACATCATGGACCTGGAGCGGCTGGATCCAGC CGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACGGGCT GGGGCTGCTCCGCGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGT CCTCCAGCCCTTCTGCGACTTTCCAGAAATCGTAGACATTAGCATCAAGCAGGCCCCGCG CGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGATTTT AGAGGCCGAGTTCCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTA CTTCCGGCTGACCACGGACTCCCAGCACTTCTTCTGCAAGGAGGTGGCACCGCCGAGGCT GCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCAACAA GCTCAAGACTGGGGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTT TGACAGCTTCCTCCTCACTGTCTGTGTCCAGAACCCCCTTGGTCCTGATTATAAGGGCTG CCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCCACAG CAGTCTTCGAGAGCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGC AGTGACCCTCACTTCCTGCTGTATCCCCAGACCCAAAGAAAAGTCCAACCTGATCGTGGT CCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACCAGCT GAGTCAGATGACATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGG CCATGGGTCCTTCACCAAGATTTACCGGGGCTGTCGCCATGAGGTGGTGGATGGGGAGGC CCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGGAGTC ATTCCTGGAAGCAGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCA CGGCGTGTGCATGGCTGGAGACAGCACCATGGTGCAGGAATTTGTACACCTGGGGGCCAT AGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGGTGGT CAAACAGCTGGCCTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGT CTCTGCCCGGAAGGTGCTCCTGGCTCGGGAGGGGGCTGATGGGAGCCCGCCCTTCATCAA GCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACAGGAT CCCCTGGGTGGCCCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAA GTGGGGCTTCGGCGCCACGGTCTGGGAAGTGTTTAGTGGCGTCACCATGCCCATCAGTGC CCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCCCCAA GTGGACAGAGCTGGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCC CTCCTTCCGAGCCGTCATTCGTGACCTCAATAGCCTCATCTCTTCAGACTATGAGCTCCT CTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCCAGCT CTATGCCTGCCAAGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCT GGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTGCCGCTATGACCCGCTAGGCGACAATAC AGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGGACTT TCAGCGGGAGATTCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGG TGTCAGCTATGGCCCGGGCCGCCAGAGCCTGCGGCTGGTCATGGAGTACCTGCCCAGCGG CTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCCTTCT CTATTCCTCGCAGATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCG CGACCTGGCCGCCCGAAACATCCTCGTGGAGAGCGAGGCACACGTCAAGATCGCTGACTT CGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCA GAGCCCCATTTTCTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTC AGACGTCTGGAGCTTCGGGGTCGTCCTGTACGAGCTCTTCACCTACTGCGACAAAAGCTG CAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTG CCGCCTCTTGGAACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGC TGAGGTTCACGAGCTCATGAAGCTGTGCTGGGCCCCTAGCCCACAGGACCGGCCATCATT CAGCGCCCTGGGCCCCCAGCTGGACATGCTGTGGAGCGGAAGCCGGGGGTGTGAGACTCA TGCCTTCACTGCTCACCCAGAGGGCAAACACCACTCCCTGTCCTTTTCATAGCTCCTGCC CGCAGACCTCTGGATTAGGTCTCTGTTGACTGGCTGTGTGACCTTAGGCCCGGAGCTGCC CCTCTCTGGGCCTCAGAGGCCTTATGAGGGTCCTCTACTTCAGGAACACCCCCACGACAT TGCATTTGGGGGGGCTCCCGTGGCCTGTAGAATAGCCTGTGGCCTTTGCAATTTGTTAAG GTTCAAGACAGATGGGCATATGTGTCAGTGGGGCTCTCTGAGTCCTGGCCCAAAGAAGCA AGGAACCAAATTTAAGACTCTCGCATCTTCCCAACCCCTTAAGCCCTGGCCCCCTGAGTT TCCTTTTCTGTCTCTCTCTTTTTATTTTTTTTATTTTTATTTTTATTTTTGAGACAGAGC CTCGCTCTGTTACCCAGGGTGGAGTGCAGTGGTGCGATCTCGGCTCAGTGCAACCTCTGC TTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTG CACCACCACACCCGGCTAATTTTTTTTATTTTTAATAGAGATGAGGTTTCACCATGATGG CCAGGCTGATCTCGAACTCCTAACCTCAAGTGATCCTCCCACCTCAGCCTCCCAAAGTGT TGGAATAATAGGCATGAGCCACTGCACCCAGGCTTTTTTTTTTTTAAATTTATTATTATT ATTTTTAAGAGACAGGATCTTGCTACGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTACA GTGATCCTCCTGCCTTATCCTCCTAAATAGCTGGGACTACAGCACCTAGTTTTGAGTTTC CTGTCTTATTTCCAATGGGGACATTCATGTAGCTTTTTTTTTTTTTTTTTTTTTGAGACG GAGTCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGCGCAATCTAGGCTCACTGCAAGCT CCGCCTCCTGGGTTCACACCATTCTCTCGCCTCAGCCTCCCAAGTAGCTGGGACTACAGG CGCCCGCCACCACACCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTG TTAGCCAGGATGGTTTCCATCTCCTGACCTCGTGATCTGCCCGTCTCGGCCTCCCAAAGT GCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCTCATGTAGCTTTAAATGTATGATC TGACTTCTGCTCCCCGATCTCTGTTTCTCTGGAGGAAGCCAAGGACAAGAGCAGTTGCTG TGGCTGGGACTCTGCCTTTTAGGGGAGCCCGTGTATCTCTTTGGGATCCTGAAAGGGGGC AGGAAAGGCTGGGGTCCCAGTCCACCCTAATGGTATCTGAGTGTCCTAGGGCTTCAGTTT TCCCACCTGTCCAATGGGACCCTTTCTGTCCTCACCCTACAAGGGGCACAAAGGGATGAC ACCAAACCTGGCAGGAACTTTTCACGCAATCAAGGGAAGGAAAGGCATTCCTGGCAGAGG GAACAGCATGCCAAGCGTGAGAAGGCTCAGAGTAAGGAGGTTAAGAGCCCAAGTATTGGA GCCTACAGTTTTGCCCCTTCCATGCAGTGTGACAGTGGGCAAGTTCCTTTCCCTCTCTGG GTCTCAGTTCTGTCCCCTGCAAAATGGTCAGAGCTTACCCCTTGGCTGTGCAGGGTCAAC TTTCTGACTGGTGAGAGGGATTCTCATGCAGGTTAAGCTTCTGCTGCTCCTCCTCACCTG CAAAGCTTTTCTGCCACTTTTGCCTCCTTGGAAAACTCTTATCCATCTCTCAAAACTCCA GCTACCACATCCTTGCAGCCTTCCCTCATATACCCCCACTACTACTGTAGCCCTGTCCTT CCCTCCAGCCCCACTCTGGCCCTGGGGCTGGGGAAGTGTCTGTGTCCAGCTGTCTCCCCT GACCTCAGGGTTCCTTGGGGGCTGGGCTGAGGCCTCAGTACAGAGGGGGCTCTGGAAATG TTTGTTGACTGAATAAAGGAATTCAGGGGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_000215 unedited
CGGCACACGGACGCCAACTAACAAGGGGGCGGCCGCGAACCCCGGGAACTCGGCCCCGCC CGCCCTCCGAAGCCAGGGCCCCCGCCCGCCAGGACCGGGAGCCCCTCCTCTCCGTGCCCC GGCAAGCCGCACTCACGGCACCCCCAAGCGAAGAGACGCCCCCGATCCCTCAGCGTTCAT GCAGCCTCTCGTCCACGGAGGCTGGTGCCCTGCATGTGCTGCTGCCCGCTCGGGGCCCCG GGCCCCCCCAGCGCCTATCTTTCTCCTTTGGGGACCACTTGGCTGAGGACCTGTGCGTGC AGGCTGCCAAGGCCAGCGGCATCCTGCCTGTGTACCACTCCCTCTTTGCTCTGGCCACGG AGGACCTGTCCTGCTGGTTCCCCCCGAGCCACATCTTCTCCGTGGAGGATGCCAGCACCC AAGTCCTGCTGTACAGGATTCGCTTTTACTTCCCCAATTGGTTTGGGCTGGAGAAGTGCC ACCGCTTCGGGCTACGCAAGGATTTGGCCAGTGCTATCCTTGACCTGCCAGTCCTGGAGC ACCTCTTTGCCCAGCACCGCAGTGACCTGGTGAGTGGGCGCCTCCCCGTGGGCCTCAGTC TCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAG AGCAGGCCCAGCGGCCGGGAGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCC CAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGTGACGCGGAGGCGTATTCGGAGGA CGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCTGCCAGGCAGACCGCACTCGCTCATGACA GTACATCATGACCTGAGCGCTGATCCAGCCGGGCCGCCGAGACCTTTCCACGTGGCCTCC CT >Forward primer walk for NM_000215 unedited
NNNCCGTGGCGAGACNAGNCACACGTNCAGGTACGCTGNACTTCGCCTAGCTAAGCTGCT GCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCAGAGCCCCATTTTCTGGTA TGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGG GGTCGTCCTGTACGAGCTCTTCACCTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTT CCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTGCCGCCTCTTGGAACTGCT GGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTTCACGAGCTCAT GAAGCTGTGCTGGGCCCCTAGCCCACAGGACCGGCCATCATTCAGCGCCCTGGGCCCCCA GCTGGACATGCTGTGGAGCGGAAGCCGGGGGTGTGAGACTCATGCCTTCACTGCTCACCC AGAGGGCAAACACCACTCCCTGTCCTTTTCATAGCTCCTGCCCGCAGACCTCTGGATTAG GTCTCTGTTGACTGGCTGTGTGACCTTAGGCCCGGAGCTGCCCCTCTCTGGGCCTCAGAG GCCTTATGAGGGTCCTCTACTTCAGGAACACCCCCACGACATTGCATTTGGGGGGGCTCC CGTGGCCTGTAGAATAGCCTGTGGCCTTTGCAATTTGTTAAGGTTCAAGACAGATGGGCA TATGTGTCAGTGGGGCTCTCTGAGTCCTGGCCCANAAAGCAGGAACCAAATTAAGACTCT CGCATCTTCCCAACCCCTTAAGCCCTGGCCCCCTGAGTTTCCTTTTCAGGCNCTCTCTTT TTATTTTTTTATTTTTATTTTTATTTTTGAGACGAGCCTCGCTCTGTTACCCAGGGTGGA G |
| Restriction Sites | Please inquire |
| ACCN | NM_000215 |
| Insert Size | 5500 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000215.2, NP_000206.2 |
| RefSeq Size | 4025 bp |
| RefSeq ORF | 3375 bp |
| Locus ID | 3718 |
| UniProt ID | P52333 |
| Domains | B41, pkinase, SH2, TyrKc, S_TKc |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Chemokine signaling pathway, Jak-STAT signaling pathway, Primary immunodeficiency |
| Gene Summary | The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Inhibition of STAT3 activation by KT-18618 via the disruption of the interaction between JAK3 and STAT3
,Shin, DS;Jung, SN;Yun, J;Lee, CW;Han, DC;Kim, B;Min, YK;Kang, NS;Kwon, BM;,
Biochem. Pharmacol.
,PubMed ID 24607275
[JAK3]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC217928 | JAK3 (Myc-DDK-tagged)-Human Janus kinase 3 (JAK3) |
CNY 11,736.00 |
|
| RC217928L1 | Lenti ORF clone of Human Janus kinase 3 (JAK3), Myc-DDK-tagged |
CNY 10,260.00 |
|
| RC217928L2 | Lenti ORF clone of Human Janus kinase 3 (JAK3), mGFP tagged |
CNY 14,136.00 |
|
| RC217928L3 | Lenti ORF clone of Human Janus kinase 3 (JAK3), Myc-DDK-tagged |
CNY 14,136.00 |
|
| RC217928L4 | Lenti ORF clone of Human Janus kinase 3 (JAK3), mGFP tagged |
CNY 14,136.00 |
|
| RG217928 | JAK3 (tGFP-tagged) - Human Janus kinase 3 (JAK3) |
CNY 13,336.00 |
