Beta TRCP (BTRC) (NM_003939) Human Untagged Clone

CAT#: SC314040

BTRC (untagged)-Human beta-transducin repeat containing (BTRC), transcript variant 2



  "NM_003939" in other vectors (4)

CNY 4,248.00

CNY 9,220.00


货期*
现货

规格
    • 10 ug

Product images

经常一起买 (4)
BTRC (Beta TRCP) mouse monoclonal antibody, clone OTI2H2 (formerly 2H2)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Synonyms BETA-TRCP; betaTrCP; bTrCP; bTrCP1; FBW1A; FBXW1; FBXW1A; FWD1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_003939 edited
CCCCGGCGGAGAGCGGACCCAGTGGCCTCGGCGATTATGGACCCGGCCGAGGCGGTGCTG
CAAGAGAAGGCACTCAAGTTTATGAATTCCTCAGAGAGAGAAGACTGTAATAATGGCGAA
CCCCCTAGGAAGATAATACCAGAGAAGAATTCACTTAGACAGACATACAACAGCTGTGCC
AGACTCTGCTTAAACCAAGAAACAGTATGTTTAGCAAGCACTGCTATGAAGACTGAGAAT
TGTGTGGCCAAAACAAAACTTGCCAATGGCACTTCCAGTATGATTGTGCCCAAGCAACGG
AAACTCTCAGCAAGCTATGAAAAGGAAAAGGAACTGTGTGTCAAATACTTTGAGCAGTGG
TCAGAGTCAGATCAAGTGGAATTTGTGGAACATCTTATATCCCAAATGTGTCATTACCAA
CATGGGCACATAAACTCGTATCTTAAACCTATGTTGCAGAGAGATTTCATAACTGCTCTG
CCAGCTCGGGGATTGGATCATATTGCTGAGAACATTCTGTCATACCTGGATGCCAAATCA
CTATGTGCTGCTGAACTTGTGTGCAAGGAATGGTACCGAGTGACCTCTGATGGCATGCTG
TGGAAGAAGCTTATCGAGAGAATGGTCAGGACAGATTCTCTGTGGAGAGGCCTGGCAGAA
CGAAGAGGATGGGGACAGTATTTATTCAAAAACAAACCTCCTGACGGGAATGCTCCTCCC
AACTCTTTTTATAGAGCACTTTATCCTAAAATTATACAAGACATTGAGACAATAGAATCT
AATTGGAGATGTGGAAGACATAGTTTACAGAGAATTCACTGCCGAAGTGAAACAAGCAAA
GGAGTTTACTGTTTACAGTATGATGATCAGAAAATAGTAAGCGGCCTTCGAGACAACACA
ATCAAGATCTGGGATAAAAACACATTGGAATGCAAGCGAATTCTCACAGGCCATACAGGT
TCAGTCCTCTGTCTCCAGTATGATGAGAGAGTGATCATAACAGGATCATCGGATTCCACG
GTCAGAGTGTGGGATGTAAATACAGGTGAAATGCTAAACACGTTGATTCACCATTGTGAA
GCAGTTCTGCACTTGCGTTTCAATAATGGCATGATGGTGACCTGCTCCAAAGATCGTTCC
ATTGCTGTATGGGATATGGCCTCCCCAACTGACATTACCCTCCGGAGGGTGCTGGTCGGA
CACCGAGCTGCTGTCAATGTTGTAGACTTTGATGACAAGTACATTGTTTCTGCATCTGGG
GATAGAACTATAAAGGTATGGAACACAAGTACTTGTGAATTTGTAAGGACCTTAAATGGA
CACAAACGAGGCATTGCCTGTTTGCAGTACAGGGACAGGCTGGTAGTGAGTGGCTCATCT
GACAACACTATCAGATTATGGGACATAGAATGTGGTGCATGTTTACGAGTGTTAGAAGGC
CATGAGGAATTGGTGCGTTGTATTCGATTTGATAACAAGAGGATAGTCAGTGGGGCCTAT
GATGGAAAAATTAAAGTGTGGGATCTTGTGGCTGCTTTGGACCCCCGTGCTCCTGCAGGG
ACACTCTGTCTACGGACCCTTGTGGAGCATTCCGGAAGAGTTTTTCGACTACAGTTTGAT
GAATTCCAGATTGTCAGTAGTTCACATGATGACACAATCCTCATCTGGGACTTCCTAAAT
GATCCAGCTGCCCAAGCTGAACCCCCCCGTTCCCCTTCTCGAACATACACCTACATCTCC
AGATAAATAACCATACACTGACCTCATACTTGCCCAGGACCCATTAAAGTTGCGGTATTT
AACGTATCTGCCAATACCAGGATGAGCAACAACAGTAACAATCAAACTACTGCCCAGTTT
CCCTGGACTAGCCGAGGAGCAGGGCTTTGAGACTCCTGTTGGGACACAGTTGGTCTGCAG
TCGGCCCAGGACGGTCTACTCAGCACAACTGACTGCTTCAGTGCTGCTATCAGAAGATGT
CTTCTATCTTTTGTGAATGATTGGAACTTTTAAACCTCCCCTCCTCTCCTCCTTTCACCT
CTGCACCTAGTTTTTTCCCATTGGTTCCAGACAAAGGTGACTTATAAATATATTTAGTGT
TTTGCCAGAATCTCTCTTGCTTTGCCATTAAGCAGAAGAACTAGTTTCCCTGTATAGCCT
GCTGGGAGAGACCCACTTCTAGGGTATGGGGGATGCAGCTTCAAGCCCAGTGCCCAGTGT
CTCCCTGTTAACTGCAGGAATGCCAAGCACCTGGCCAGAGCAGCCCAGCCCCAATATGCT
TAGGAGGAGACAGAGTTCCCTCTGTATAGCCTCTGGGACAAGAAAAAGAAAACACAAGAA
TGTATACACTGGAAGATTTGGGCCTCCTGCCTGCCTTCTCTTTGTTTCTGTTCCTCTTCC
CATCTACTCCCCTACGCCCCTTCAACCTTTTTTCTCTGTCTGCTTCACCTGAGAAGAAAG
TGTACGAAGAGAGTGTCCTCCTCTCACATGAGCCAGATCAGCCAGAAAATGCAACACTTG
GAAGAGTTAAATGCTGTTCAGTGAAGATTTCAGCCCCAGGCCTTTGCTGCAAGTGACCCT
GTGGCAACAGTGGATTCTCAGACATGATACTCTCATCATATTTGCAACTCTTCTCTCTCT
TTCTTCCCCACACCCAAGAGGAGGATTGGTGGTAGGGGGCAGGCAGAGGGGGTGGGGAGA
AGTTTCCTGGGCTCCATCAATGGCTGCATCTTTTCTGGACTCAGCAGTCTCCTTGATTCC
ATGTAGAGTGTGGAAAGGAGTTGCTGATTGCATTTCCTCTCATTAACAATTGGGTGTGTA
ATAAAAAGCATTGTACTTCATCTTAAAAAAAAAAAAAAAAAAAACTCGAC
Restriction Sites Please inquire     
ACCN NM_003939
Insert Size 2900 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation The ORF of this clone has been fully sequenced and found to be a perfect match to NM_003939.2.
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq NM_003939.2, NP_003930.1
RefSeq Size 6038 bp
RefSeq ORF 1710 bp
Locus ID 8945
UniProt ID Q9Y297
Domains WD40, F-box
Protein Families Druggable Genome
Protein Pathways Hedgehog signaling pathway, Oocyte meiosis, Ubiquitin mediated proteolysis, Wnt signaling pathway
Gene Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Sequence Note:.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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