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PTCH1 (NM_001083602) Human Untagged Clone
CAT＃: SC316083
PTCH1 (untagged)-Human patched 1 (PTCH1), transcript variant 1a
CNY 26,600.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BCNS; NBCCS; PTC; PTC1; PTCH |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_001083602, the custom clone sequence may differ by one or more nucleotides
ATGGGGAAGGCTACTGGCCGGAAAGCGCCGCTGTGGCTGAGAGCGAAGTTTCAGAGACTC TTATTTAAACTGGGTTGTTACATTCAAAAAAACTGCGGCAAGTTCTTGGTTGTGGGCCTC CTCATATTTGGGGCCTTCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAG GAGCTGTGGGTGGAAGTTGGAGGACGAGTAAGTCGTGAATTAAATTATACTCGCCAGAAG ATTGGAGAAGAGGCTATGTTTAATCCTCAACTCATGATACAGACCCCTAAAGAAGAAGGT GCTAATGTCCTGACCACAGAAGCGCTCCTACAACACCTGGACTCGGCACTCCAGGCCAGC CGTGTCCATGTATACATGTACAACAGGCAGTGGAAATTGGAACATTTGTGTTACAAATCA GGAGAGCTTATCACAGAAACAGGTTACATGGATCAGATAATAGAATATCTTTACCCTTGT TTGATTATTACACCTTTGGACTGCTTCTGGGAAGGGGCGAAATTACAGTCTGGGACAGCA TACCTCCTAGGTAAACCTCCTTTGCGGTGGACAAACTTCGACCCTTTGGAATTCCTGGAA GAGTTAAAGAAAATAAACTATCAAGTGGACAGCTGGGAGGAAATGCTGAATAAGGCTGAG GTTGGTCATGGTTACATGGACCGCCCCTGCCTCAATCCGGCCGATCCAGACTGCCCCGCC ACAGCCCCCAACAAAAATTCAACCAAACCTCTTGATATGGCCCTTGTTTTGAATGGTGGA TGTCATGGCTTATCCAGAAAGTATATGCACTGGCAGGAGGAGTTGATTGTGGGTGGCACA GTCAAGAACAGCACTGGAAAACTCGTCAGCGCCCATGCCCTGCAGACCATGTTCCAGTTA ATGACTCCCAAGCAAATGTACGAGCACTTCAAGGGGTACGAGTATGTCTCACACATCAAC TGGAACGAGGACAAAGCGGCAGCCATCCTGGAGGCCTGGCAGAGGACATATGTGGAGGTG GTTCATCAGAGTGTCGCACAGAACTCCACTCAAAAGGTGCTTTCCTTCACCACCACGACC CTGGACGACATCCTGAAATCCTTCTCTGACGTCAGTGTCATCCGCGTGGCCAGCGGCTAC TTACTCATGCTCGCCTATGCCTGTCTAACCATGCTGCGCTGGGACTGCTCCAAGTCCCAG GGTGCCGTGGGGCTGGCTGGCGTCCTGCTGGTTGCACTGTCAGTGGCTGCAGGACTGGGC CTGTGCTCATTGATCGGAATTTCCTTTAACGCTGCAACAACTCAGGTTTTGCCATTTCTC GCTCTTGGTGTTGGTGTGGATGATGTTTTTCTTCTGGCCCACGCCTTCAGTGAAACAGGA CAGAATAAAAGAATCCCTTTTGAGGACAGGACCGGGGAGTGCCTGAAGCGCACAGGAGCC AGCGTGGCCCTCACGTCCATCAGCAATGTCACAGCCTTCTTCATGGCCGCGTTAATCCCA ATTCCCGCTCTGCGGGCGTTCTCCCTCCAGGCAGCGGTAGTAGTGGTGTTCAATTTTGCC ATGGTTCTGCTCATTTTTCCTGCAATTCTCAGCATGGATTTATATCGACGCGAGGACAGG AGACTGGATATTTTCTGCTGTTTTACAAGCCCCTGCGTCAGCAGAGTGATTCAGGTTGAA CCTCAGGCCTACACCGACACACACGACAATACCCGCTACAGCCCCCCACCTCCCTACAGC AGCCACAGCTTTGCCCATGAAACGCAGATTACCATGCAGTCCACTGTCCAGCTCCGCACG GAGTACGACCCCCACACGCACGTGTACTACACCACCGCTGAGCCGCGCTCCGAGATCTCT GTGCAGCCCGTCACCGTGACACAGGACACCCTCAGCTGCCAGAGCCCAGAGAGCACCAGC TCCACAAGGGACCTGCTCTCCCAGTTCTCCGACTCCAGCCTCCACTGCCTCGAGCCCCCC TGTACGAAGTGGACACTCTCATCTTTTGCTGAGAAGCACTATGCTCCTTTCCTCTTGAAA CCAAAAGCCAAGGTAGTGGTGATCTTCCTTTTTCTGGGCTTGCTGGGGGTCAGCCTTTAT GGCACCACCCGAGTGAGAGACGGGCTGGACCTTACGGACATTGTACCTCGGGAAACCAGA GAATATGACTTTATTGCTGCACAATTCAAATACTTTTCTTTCTACAACATGTATATAGTC ACCCAGAAAGCAGACTACCCGAATATCCAGCACTTACTTTACGACCTACACAGGAGTTTC AGTAACGTGAAGTATGTCATGTTGGAAGAAAACAAACAGCTTCCCAAAATGTGGCTGCAC TACTTCAGAGACTGGCTTCAGGGACTTCAGGATGCATTTGACAGTGACTGGGAAACCGGG AAAATCATGCCAAACAATTACAAGAATGGATCAGACGATGGAGTCCTTGCCTACAAACTC CTGGTGCAAACCGGCAGCCGCGATAAGCCCATCGACATCAGCCAGTTGACTAAACAGCGT CTGGTGGATGCAGATGGCATCATTAATCCCAGCGCTTTCTACATCTACCTGACGGCTTGG GTCAGCAACGACCCCGTCGCGTATGCTGCCTCCCAGGCCAACATCCGGCCACACCGACCA GAATGGGTCCACGACAAAGCCGACTACATGCCTGAAACAAGGCTGAGAATCCCGGCAGCA GAGCCCATCGAGTATGCCCAGTTCCCTTTCTACCTCAACGGCTTGCGGGACACCTCAGAC TTTGTGGAGGCAATTGAAAAAGTAAGGACCATCTGCAGCAACTATACGAGCCTGGGGCTG TCCAGTTACCCCAACGGCTACCCCTTCCTCTTCTGGGAGCAGTACATCGGCCTCCGCCAC TGGCTGCTGCTGTTCATCAGCGTGGTGTTGGCCTGCACATTCCTCGTGTGCGCTGTCTTC CTTCTGAACCCCTGGACGGCCGGGATCATTGTGATGGTCCTGGCGCTGATGACGGTCGAG CTGTTCGGCATGATGGGCCTCATCGGAATCAAGCTCAGTGCCGTGCCCGTGGTCATCCTG ATCGCTTCTGTTGGCATAGGAGTGGAGTTCACCGTTCACGTTGCTTTGGCCTTTCTGACG GCCATCGGCGACAAGAACCGCAGGGCTGTGCTTGCCCTGGAGCACATGTTTGCACCCGTC CTGGATGGCGCCGTGTCCACTCTGCTGGGAGTGCTGATGCTGGCGGGATCTGAGTTCGAC TTCATTGTCAGGTATTTCTTTGCTGTGCTGGCGATCCTCACCATCCTCGGCGTTCTCAAT GGGCTGGTTTTGCTTCCCGTGCTTTTGTCTTTCTTTGGACCATATCCTGAGGTGTCTCCA GCCAACGGCTTGAACCGCCTGCCCACACCCTCCCCTGAGCCACCCCCCAGCGTGGTCCGC TTCGCCATGCCGCCCGGCCACACGCACAGCGGGTCTGATTCCTCCGACTCGGAGTATAGT TCCCAGACGACAGTGTCAGGCCTCAGCGAGGAGCTTCGGCACTACGAGGCCCAGCAGGGC GCGGGAGGCCCTGCCCACCAAGTGATCGTGGAAGCCACAGAAAACCCCGTCTTCGCCCAC TCCACTGTGGTCCATCCCGAATCCAGGCATCACCCACCCTCGAACCCGAGACAGCAGCCC CACCTGGACTCAGGGTCCCTGCCTCCCGGACGGCAAGGCCAGCAGCCCCGCAGGGACCCC CCCAGAGAAGGCTTGTGGCCACCCCCCTACAGACCGCGCAGAGACGCTTTTGAAATTTCT ACTGAAGGGCATTCTGGCCCTAGCAATAGGGCCCGCTGGGGCCCTCGCGGGGCCCGTTCT CACAACCCTCGGAACCCAGCGTCCACTGCCATGGGCAGCTCCGTGCCCGGCTACTGCCAG CCCATCACCACTGTGACGGCTTCTGCCTCCGTGACTGTCGCCGTGCACCCGCCGCCTGTC CCTGGGCCTGGGCGGAACCCCCGAGGGGGACTCTGCCCAGGCTACCCTGAGACTGACCAC GGCCTGTTTGAGGACCCCCACGTGCCTTTCCACGTCCGGTGTGAGAGGAGGGATTCGAAG GTGGAAGTCATTGAGCTGCAGGACGTGGAATGCGAGGAGAGGCCCCGGGGAAGCAGCTCC AAC |
| Restriction Sites | Please inquire |
| ACCN | NM_001083602 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001083602.1, NP_001077071.1 |
| RefSeq Size | 8065 bp |
| RefSeq ORF | 4146 bp |
| Locus ID | 5727 |
| UniProt ID | Q13635 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer |
| Gene Summary | This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017] Transcript Variant: This variant (1a) differs in the 5' UTR and has multiple differences in the 5' coding region, compared to variant 1b. These differences result in a protein (isoform M) with a shorter N-terminus and distinct translation initiation site, compared to isoform L. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC217046 | PTCH1 (Myc-DDK-tagged)-Human patched 1 (PTCH1), transcript variant 1a |
CNY 14,176.00 |
|
| RC217046L3 | Lenti-ORF clone of PTCH1 (Myc-DDK-tagged)-Human patched 1 (PTCH1), transcript variant 1a |
CNY 15,680.00 |
|
| RC217046L4 | Lenti-ORF clone of PTCH1 (mGFP-tagged)-Human patched 1 (PTCH1), transcript variant 1a |
CNY 15,680.00 |
|
| RG217046 | PTCH1 (tGFP-tagged) - Human patched 1 (PTCH1), transcript variant 1a |
CNY 15,200.00 |
