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Integrin beta 4 (ITGB4) (NM_000213) Human Untagged Clone
CAT＃: SC316295
ITGB4 (untagged)-Human integrin, beta 4 (ITGB4), transcript variant 1
CNY 12,256.00
货期*
现货
规格
| Cited in 1 publication. |
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD104; GP150 |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000213 edited
CCCGCGCCCGCCCTCGGACAGTCCCTGCTCGCCCGCGCGCTGCAGCCCCATCTCCTAGCG GCAGCCCAGGCGCGGAGGGAGCGAGTCCGCCCCGAGGTAGGTCCAGGACGGGCGCACAGC AGCAGCCGAGGCTGGCCGGGAGAGGGAGGAAGAGGATGGCAGGGCCACGCCCCAGCCCAT GGGCCAGGCTGCTCCTGGCAGCCTTGATCAGCGTCAGCCTCTCTGGGACCTTGGCAAACC GCTGCAAGAAGGCCCCAGTGAAGAGCTGCACGGAGTGTGTCCGTGTGGATAAGGACTGCG CCTACTGCACAGACGAGATGTTCAGGGACCGGCGCTGCAACACCCAGGCGGAGCTGCTGG CCGCGGGCTGCCAGCGGGAGAGCATCGTGGTCATGGAGAGCAGCTTCCAAATCACAGAGG AGACCCAGATTGACACCACCCTGCGGCGCAGCCAGATGTCCCCCCAAGGCCTGCGGGTCC GTCTGCGGCCCGGTGAGGAGCGGCATTTTGAGCTGGAGGTGTTTGAGCCACTGGAGAGCC CCGTGGACCTGTACATCCTCATGGACTTCTCCAACTCCATGTCCGATGATCTGGACAACC TCAAGAAGATGGGGCAGAACCTGGCTCGGGTCCTGAGCCAGCTCACCAGCGACTACACTA TTGGATTTGGCAAGTTTGTGGACAAAGTCAGCGTCCCGCAGACGGACATGAGGCCTGAGA AGCTGAAGGAGCCCTGGCCCAACAGTGACCCCCCCTTCTCCTTCAAGAACGTCATCAGCC TGACAGAAGATGTGGATGAGTTCCGGAATAAACTGCAGGGAGAGCGGATCTCAGGCAACC TGGATGCTCCTGAGGGCGGCTTCGATGCCATCCTGCAGACAGCTGTGTGCACGAGGGACA TTGGCTGGCGCCCGGACAGCACCCACCTGCTGGTCTTCTCCACCGAGTCAGCCTTCCACT ATGAGGCTGATGGCGCCAACGTGCTGGCTGGCATCATGAGCCGCAACGATGAACGGTGCC ACCTGGACACCACGGGCACCTACACCCAGTACAGGACACAGGACTACCCGTCGGTGCCCA CCCTGGTGCGCCTGCTCGCCAAGCACAACATCATCCCCATCTTTGCTGTCACCAACTACT CCTATAGCTACTACGAGAAGCTTCACACCTATTTCCCTGTCTCCTCACTGGGGGTGCTGC AGGAGGACTCGTCCAACATCGTGGAGCTGCTGGAGGAGGCCTTCAATCGGATCCGCTCCA ACCTGGACATCCGGGCCCTAGACAGCCCCCGAGGCCTTCGGACAGAGGTCACCTCCAAGA TGTTCCAGAAGACGAGGACTGGGTCCTTTCACATCCGGCGGGGGGAAGTGGGTATATACC AGGTGCAGCTGCGGGCCCTTGAGCACGTGGATGGGACGCACGTGTGCCAGCTGCCGGAGG ACCAGAAGGGCAACATCCATCTGAAACCTTCCTTCTCCGACGGCCTCAAGATGGACGCGG GCATCATCTGTGATGTGTGCACCTGCGAGCTGCAAAAAGAGGTGCGGTCAGCTCGCTGCA GCTTCAACGGAGACTTCGTGTGCGGACAGTGTGTGTGCAGCGAGGGCTGGAGTGGCCAGA CCTGCAACTGCTCCACCGGCTCTCTGAGTGACATTCAGCCCTGCCTGCGGGAGGGCGAGG ACAAGCCGTGCTCCGGCCGTGGGGAGTGCCAGTGCGGGCACTGTGTGTGCTACGGCGAAG GCCGCTACGAGGGTCAGTTCTGCGAGTATGACAACTTCCAGTGTCCCCGCACTTCCGGGT TCCTCTGCAATGACCGAGGACGCTGCTCCATGGGCCAGTGTGTGTGTGAGCCTGGTTGGA CAGGCCCAAGCTGTGACTGTCCCCTCAGCAATGCCACCTGCATCGACAGCAATGGGGGCA TCTGTAATGGACGTGGCCACTGTGAGTGTGGCCGCTGCCACTGCCACCAGCAGTCGCTCT ACACGGACACCATCTGCGAGATCAACTACTCGGCGATCCACCCGGGCCTCTGCGAGGACC TACGCTCCTGCGTGCAGTGCCAGGCGTGGGGCACCGGCGAGAAGAAGGGGCGCACGTGTG AGGAATGCAACTTCAAGGTCAAGATGGTGGACGAGCTTAAGAGAGCCGAGGAGGTGGTGG TGCGCTGCTCCTTCCGGGACGAGGATGACGACTGCACCTACAGCTACACCATGGAAGGTG ACGGCGCCCCTGGGCCCAACAGCACTGTCCTGGTGCACAAGAAGAAGGACTGCCCTCCGG GCTCCTTCTGGTGGCTCATCCCCCTGCTCCTCCTCCTCCTGCCGCTCCTGGCCCTGCTAC TGCTGCTATGCTGGAAGTACTGTGCCTGCTGCAAGGCCTGCCTGGCACTTCTCCCGTGCT GCAACCGAGGTCACATGGTGGGCTTTAAGGAAGACCACTACATGCTGCGGGAGAACCTGA TGGCCTCTGACCACTTGGACACGCCCATGCTGCGCAGCGGGAACCTCAAGGGCCGTGACG TGGTCCGCTGGAAGGTCACCAACAACATGCAGCGGCCTGGCTTTGCCACTCATGCCGCCA GCATCAACCCCACAGAGCTGGTGCCCTACGGGCTGTCCTTGCGCCTGGCCCGCCTTTGCA CCGAGAACCTGCTGAAGCCTGACACTCGGGAGTGCGCCCAGCTGCGCCAGGAGGTGGAGG AGAACCTGAACGAGGTCTACAGGCAGATCTCCGGTGTACACAAGCTCCAGCAGACCAAGT TCCGGCAGCAGCCCAATGCCGGGAAAAAGCAAGACCACACCATTGTGGACACAGTGCTGA TGGCGCCCCGCTCGGCCAAGCCGGCCCTGCTGAAGCTTACAGAGAAGCAGGTGGAACAGA GGGCCTTCCACGACCTCAAGGTGGCCCCCGGCTACTACACCCTCACTGCAGACCAGGACG CCCGGGGCATGGTGGAGTTCCAGGAGGGCGTGGAGCTGGTGGACGTACGGGTGCCCCTCT TTATCCGGCCTGAGGATGACGACGAGAAGCAGCTGCTGGTGGAGGCCATCGACGTGCCCG CAGGCACTGCCACCCTCGGCCGCCGCCTGGTAAACATCACCATCATCAAGGAGCAAGCCA GAGACGTGGTGTCCTTTGAGCAGCCTGAGTTCTCGGTCAGCCGCGGGGACCAGGTGGCCC GCATCCCTGTCATCCGGCGTGTCCTGGACGGCGGGAAGTCCCAGGTCTCCTACCGCACAC AGGATGGCACCGCGCAGGGCAACCGGGACTACATCCCCGTGGAGGGTGAGCTGCTGTTCC AGCCTGGGGAGGCCTGGAAAGAGCTGCAGGTGAAGCTCCTGGAGCTGCAAGAAGTTGACT CCCTCCTGCGGGGCCGCCAGGTCCGCCGTTTCCACGTCCAGCTCAGCAACCCTAAGTTTG GGGCCCACCTGGGCCAGCCCCACTCCACCACCATCATCATCAGGGACCCAGATGAACTGG ACCGGAGCTTCACGAGTCAGATGTTGTCATCACAGCCACCCCCTCACGGCGACCTGGGCG CCCCGCAGAACCCCAATGCTAAGGCCGCTGGGTCCAGGAAGATCCATTTCAACTGGCTGC CCCCTTCTGGCAAGCCAATGGGGTACAGGGTAAAGTACTGGATTCAGGGTGACTCCGAAT CCGAAGCCCACCTGCTCGACAGCAAGGTGCCCTCAGTGGAGCTCACCAACCTGTACCCGT ATTGCGACTATGAGATGAAGGTGTGCGCCTACGGGGCTCAGGGCGAGGGACCCTACAGCT CCCTGGTGTCCTGCCGCACCCACCAGGAAGTGCCCAGCGAGCCAGGGCGTCTGGCCTTCA ATGTCGTCTCCTCCACGGTGACCCAGCTGAGCTGGGCTGAGCCGGCTGAGACCAACGGTG AGATCACAGCCTACGAGGTCTGCTATGGCCTGGTCAACGATGACAACCGACCTATTGGGC CCATGAAGAAAGTGCTGGTTGACAACCCTAAGAACCGGATGCTGCTTATTGAGAACCTTC GGGAGTCCCAGCCCTACCGCTACACGGTGAAGGCGCGCAACGGGGCCGGCTGGGGGCCTG AGCGGGAGGCCATCATCAACCTGGCCACCCAGCCCAAGAGGCCCATGTCCATCCCCATCA TCCCTGACATCCCTATCGTGGACGCCCAGAGCGGGGAGGACTACGACAGCTTCCTTATGT ACAGCGATGACGTTCTACGCTCTCCATCGGGCAGCCAGAGGCCCAGCGTCTCCGATGACA CTGGCTGCGGCTGGAAGTTCGAGCCCCTGCTGGGGGAGGAGCTGGACCTGCGGCGCGTCA CGTGGCGGCTGCCCCCGGAGCTCATCCCGCGCCTGTCGGCCAGCAGCGGGCGCTCCTCCG ACGCCGAGGCGCCCCACGGGCCCCCGGACGACGGCGGCGCGGGCGGGAAGGGCGGCAGCC TGCCCCGCAGTGCGACACCCGGGCCCCCCGGAGAGCACCTGGTGAATGGCCGGATGGACT TTGCCTTCCCGGGCAGCACCAACTCCCTGCACAGGATGACCACGACCAGTGCTGCTGCCT ATGGCACCCACCTGAGCCCACACGTGCCCCACCGCGTGCTAAGCACATCCTCCACCCTCA CACGGGACTACAACTCACTGACCCGCTCAGAACACTCACACTCGACCACACTGCCGAGGG ACTACTCCACCCTCACCTCCGTCTCCTCCCACGACTCTCGCCTGACTGCTGGTGTGCCCG ACACGCCCACCCGCCTGGTGTTCTCTGCCCTGGGGCCCACATCTCTCAGAGTGAGCTGGC AGGAGCCGCGGTGCGAGCGGCCGCTGCAGGGCTACAGTGTGGAGTACCAGCTGCTGAACG GCGGTGAGCTGCATCGGCTCAACATCCCCAACCCTGCCCAGACCTCGGTGGTGGTGGAAG ACCTCCTGCCCAACCACTCCTACGTGTTCCGCGTGCGGGCCCAGAGCCAGGAAGGCTGGG GCCGAGAGCGTGAGGGTGTCATCACCATTGAATCCCAGGTGCACCCGCAGAGCCCACTGT GTCCCCTGCCAGGCTCCGCCTTCACTTTGAGCACTCCCAGTGCCCCAGGCCCGCTGGTGT TCACTGCCCTGAGCCCAGACTCGCTGCAGCTGAGCTGGGAGCGGCCACGGAGGCCCAATG GGGATATCGTCGGCTACCTGGTGACCTGTGAGATGGCCCAAGGAGGAGGGCCAGCCACCG CATTCCGGGTGGATGGAGACAGCCCCGAGAGCCGGCTGACCGTGCCGGGCCTCAGCGAGA ACGTGCCCTACAAGTTCAAGGTGCAGGCCAGGACCACTGAGGGCTTCGGGCCAGAGCGCG AGGGCATCATCACCATAGAGTCCCAGGATGGAGGACCCTTCCCGCAGCTGGGCAGCCGTG CCGGGCTCTTCCAGCACCCGCTGCAAAGCGAGTACAGCAGCATCACCACCACCCACACCA GCGCCACCGAGCCCTTCCTAGTGGATGGGCCGACCCTGGGGGCCCAGCACCTGGAGGCAG GCGGCTCCCTCACCCGGCATGTGACCCAGGAGTTTGTGAGCCGGACACTGACCACCAGCG GAACCCTTAGCACCCACATGGACCAACAGTTCTTCCAAACTTGACCGCACCCTGCCCCAC CCCCGCCATGTCCCACTAGGCGTCCTCCCGACTCCTCTCCCGGAGCCTCCTCAGCTACTC CATCCTTGCACCCCTGGGGGCCCAGCCCACCCGCATGCACAGAGCAGGGGCTAGGTGTCT CCTGGGAGGCATGAAGGGGGCAAGGTCCGTCCTCTGTGGGCCCAAACCTATTTGTAACCA AAGAGCTGGGAGCAGCACAAGGACCCAGCCTTTGTTCTGCACTTAATAAATGGTTTTGCT ACTGCTAAAAAAAAAAAAAAAA >OriGene 5' read for NM_000213 unedited
GGGCACGTTGTAGCAGAGGGCGGTAGGCGCGGGGAGTGGGAGGTCTCTATCAGCACAGCT CATTTATGCGAAACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAATTCG GCACGAGGCCCGCGCCCGCCCTCGGACAGTCCCTGCTCGCCCGCGCGCTGCAGCCCCATC TCCTAGCGGCAGCCCAGGCGCGGAGGGAGCGAGTCCGCCCCGAGGTAGGTCCAGGACGGG CGCACAGCAGCAGCCGAGGCTGGCCGGGAGAGGGAGGAAGAGGATGGCAGGGCCACGCCC CAGCCCATGGGCCAGGCTGCTCCTGGCAGCCTTGATCAGCGTCAGCCTCTCTGGGACCTT GGCAAACCGCTGCAAGAAGGCCCCAGTGAAGAGCTGCACGGAGTGTGTCCGTGTGGATAA GGACTGCGCCTACTGCACAGACGAGATGTTCAGGGACCGGCGCTGCAACACCCAGGCGGA GCTGCTGGCCGCGGGCTGCCAGCGGGAGAGCATCGTGGTCATGGAGAGCAGCTTCCAAAT CACAGAGGAGACCCAGATTGACACCACCCTGCGGCGCAGCCAGATGTCCCCCCAAGGCCT GCGGGTCCGTCTGCGGCCCGGTGAGGAGCGGCATTTTGAGCTGGAGGTGTTTGAGCCACT GGAGAGCCCCGTGGACCTGTACATCCTCATGGACTTCTCCAACTCCATGTCCGATGATCT GGACAACCTCAAGAAGATGGGGCAGAACCTGGCTCGGGTCCTGAGCCAGCTCACCAGCGA CTACACTATTGGGATTTGGCAAGTTTGTGGACAAAGTCAGCGTCCCCGCAGACGGACATG AGGCCTGAGAAGCTGAAAGGAGCCCTGGCCCACCAGTG >OriGene 3' read for NM_000213 unedited
TGCGATGCACTTCAGGGCCGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGA TCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTT TTTTAGCAGTAGCAAAACCATTTATTAAGTGCAGAACAAAGGCTGGGTCCTTGTGCTGCT CCCAGCTCTTTGGTTACAAATAGGTTTGGGCCCACAGAGGACGGACCTTGCCCCCTTCAT GCCTCCCAGGAGACACCTAGCCCCTGCTCTGTGCATGCGGGTGGGCTGGGCCCCCAGGGG TGCAAGGATGGAGTAGCTGAGGAGGCTCCGGGAGAGGAGTCGGGAGGACGCCTAGTGGGA CATGGCGGGGGTGGGGCAGGGTGCGGTCAAGTTTGGAAGAACTGTTGGTCCATGTGGGTG CTAAGGGTTCCGCTGGTGGTCAGTGTCCGGCTCACAAACTCCTGGGTCACATGCCGGGTG AGGGAGCCGCCTGCCTCCAGGTGCTGGGCCCCCAGGGTCGGCCCATCCACTAGGAAGGGC TCGGTGGCGCTGGTGTGGGTGGTGGTGATGCTGCTGTACTCGCTTTGCAGCGGGTGCTGG AAGAGCCCGGCACGGCTGCCCAGCTGCGGGAAGGGTCCTCCATCCTGGGACTCTATGGTG ATGATGCCCTCGCGCTCTGGCCCGAAGCCCTCAGTGGTCCTGGCCTGCACCTTGAACTTG TAGGGCACGTTCTCGCTGAGCCCGGCACGGTCAGCCGGCTCTCGGGGCTGTCTCCATCCA CCCGGAATGCGGTGGCTGGCCCTCCTCCTTGGGCCATCTCACAGGTCACCAGGTAGCCGA CGATATCCCATTGGGCCTCGTGCCGCTCCAGCTCAGCTGCAGCGAGTCTGGCTCAGCAGT GAACACAGCGGCTGGGCACTGGGAGTGCTCAAGTGAGCGACTGCAGGGACACAGTGGCTC TGCGGGTGCACCTGGATC |
| Restriction Sites | Please inquire |
| ACCN | NM_000213 |
| Insert Size | 5900 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.NA |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000213.3, NP_000204.3 |
| RefSeq Size | 5925 bp |
| RefSeq ORF | 5469 bp |
| Locus ID | 3691 |
| UniProt ID | P16144 |
| Domains | INB, Calx-beta, PSI, FN3, EGF |
| Protein Families | Druggable Genome |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton |
| Gene Summary | Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) encodes the longest isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Galectin-1 promotes lung cancer tumor metastasis by potentiating integrin a6ß4 and Notch1/Jagged2 signaling pathway
,Ya-Ling Hsu, Cheng-Ying Wu, Jen-Yu Hung, Yi-Shiuan Lin, Ming-Shyan Huang, and Po-Lin Kuo,
Carcinogenesis, Jun 2013; 34: 1370 - 1381.
,PubMed ID 23389289
[ITGB4]
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