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p15 INK4b (CDKN2B) (NM_004936) Human Untagged Clone
CAT＃: SC319536
CDKN2B (untagged)-Human cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1
CNY 1,200.00
CNY 2,950.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CDK4I; INK4B; MTS2; P15; p15INK4b; TP15 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_004936.3
GTGAGGACTCCGCGACGCGTCCGCACCCTGCGGCCAGAGCGGCTTTGAGCTCGGCTGCGT
CCGCGCTAGGCGCTTTTTCCCAGAAGCAATCCAGGCGCGCCCGCTGGTTCTTGAGCGCCA GGAAAAGCCCGGAGCTAACGACCGGCCGCTCGGCCACTGCACGGGGCCCCAAGCCGCAGA AGGACGACGGGAGGGTAATGAAGCTGAGCCCAGGTCTCCTAGGAAGGAGAGAGTGCGCCG GAGCAGCGTGGGAAAGAAGGGAAGAGTGTCGTTAAGTTTACGGCCAACGGTGGATTATCC GGGCCGCTGCGCGTCTGGGGGCTGCGGAATGCGCGAGGAGAACAAGGGCATGCCCAGTGG GGGCGGCAGCGATGAGGGTCTGGCCAGCGCCGCGGCGCGGGGACTAGTGGAGAAGGTGCG ACAGCTCCTGGAAGCCGGCGCGGATCCCAACGGAGTCAACCGTTTCGGGAGGCGCGCGAT CCAGGTCATGATGATGGGCAGCGCCCGCGTGGCGGAGCTGCTGCTGCTCCACGGCGCGGA GCCCAACTGCGCAGACCCTGCCACTCTCACCCGACCGGTGCATGATGCTGCCCGGGAGGG CTTCCTGGACACGCTGGTGGTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGATGC CTGGGGTCGTCTGCCCGTGGACTTGGCCGAGGAGCGGGGCCACCGCGACGTTGCAGGGTA CCTGCGCACAGCCACGGGGGACTGACGCCAGGTTCCCCAGCCGCCCACAACGACTTTATT TTCTTACCCAATTTCCCACCCCCACCCACCTAATTCGATGAAGGCTGCCAACGGGGAGCG GCGGAAAGCCTGTAAGCCTGCAAGCCTGTCTGAGACTCACAGGAAGGAGGAGCCGACCGG GAATAACCTTCCATACATTTTTTTCTTTGTCTTATCTGGCCCTCGACACTCACCATGAAG CGAAACACAGAGAAGCGGATTTCCAGGGATATTTAGGAGTGTGTGACATTCCAGGGGTCG TTTGCTTTTCAGGGTTTTCTGAGGGAAAGTGCATATGAAATCCTTGACTGGACCTGGTGG CTACGAATCTTCCGATGGATGAATCTCCCACTCCAGCGCTGAGTGGGAGAAGGCAGTGAT TAGCACTTGGGTGACGGCAGTCGATGCGTTCACTCCAATGTCTGCTGAGGAGTTATGGTG AACCCACAACTTAGGCCCTAGCGGCAGAAAGGAAAACCTGAAGACTGAGGACAAAGTGGA GGAGGGCCGAGGTGGGCTTCAGTAAGTCCCCGGCGGCGCTTTAGTTTGAGCGCATGGCAA GTCACATGCGTAAACGACACTCTCTGGAAGCCCTGGAGACCCTCGCCCAACTCCACCAGA TAGCAGAGGGGTAAGAGAGGATGTGCAAGCGACGACAGATGCTAAAATCCCTGGATCACG ACGCTGCAGAGCACCTTTGCACAGGATGCTGGCCTTTGCTCTTACTACACTGAGGAGAGA TTCCCGCGGGTTCCGCAGGCAGACTACACAGGATGAGGTGGTGGAGTGGAGTGAGAGCAA TTGTAACGGTTAACTGTAACGTTTTCTTTCACACACACACACACACACACACACACACAC ATGCTAGGATGCGGAAATCCCCTTATGACTTGCTACTTTTTGATTTTGTGATATTTTGTA CTTTTTAGTTGTTCAGCAACTGTCTTATTTAATGGGGAGATTTTAAGTAACATAACTAGT GGCTCTCAGTTAAAATGTGAGGAAGAACTACAGCTCTTAAATGTAGCAATGGCACTGTTG CAAACTCAGTGCAAACGCCTAGATTGCTTTCTTCTTAACCTATTTATTTCTTTGTTAAAT TTTTCTGATTGTTTCCTTTATAGAGTGTCTCAGGGTGCAGAGGTCAGACTAAGAAATATT CCAAATGTCTTTTAGAAGATAGATGCACTTATGCAGTAAATTATCTTGGGATAGTTCCCA AAAGATTGCTGAAAAAGTAGATTGAGTATAAAAACTTGAAAATATATGATGGCTCGTGGG ATGTCCTACTATCACTGAACAAACTAAAGGTGCACTGCTTTGGGATTTAATTTCCAGGGT TGCTTGATCATTATATCATTGGAACAACTGATACTTCACTACTTTAATAAAGAATTAACA GAGATTGAACTCCAAGAGGTGGGTAATTTGGTTTAAAAATACATGTTCATGGGTTTACCA CTAACTCCTGAGAAATGTTAAAGGTTCACAGGGGTTCCCTTCTCTCAATGTTTGTAATAA TTGCTCATAAGCAATACCAGCAATTCATAAAAACTGCTTACTTATGCCATAGAAAATTAA ACACAAAGTGTATACATGTAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_004936 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004936.3, NP_004927.2 |
| RefSeq Size | 3878 bp |
| RefSeq ORF | 417 bp |
| Locus ID | 1030 |
| UniProt ID | P42772 |
| Domains | ANK |
| Protein Families | Druggable Genome |
| Protein Pathways | Cell cycle, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway |
| Gene Summary | This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) encodes the longer isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
,Kojima, Y;Downing, K;Kundu, R;Miller, C;Dewey, F;Lancero, H;Raaz, U;Perisic, L;Hedin, U;Schadt, E;Maegdefessel, L;Quertermous, T;Leeper, NJ;,
J. Clin. Invest., Feb 2014.
,PubMed ID 24531546
[CDKN2B]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204895 | CDKN2B (Myc-DDK-tagged)-Human cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1 |
CNY 1,200.00 |
|
| RC204895L1 | Lenti ORF clone of Human cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1, Myc-DDK-tagged |
CNY 3,600.00 |
|
| RC204895L2 | Lenti ORF clone of Human cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1, mGFP tagged |
CNY 3,600.00 |
|
| RC204895L3 | Lenti ORF clone of Human cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC204895L4 | Lenti ORF clone of Human cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1, mGFP tagged |
CNY 3,600.00 |
|
| RG204895 | CDKN2B (tGFP-tagged) - Human cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1 |
CNY 2,800.00 |
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