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E3 ubiquitin protein ligase MUL1 (MUL1) (NM_024544) Human Untagged Clone
CAT＃: SC321149
MUL1 (untagged)-Human mitochondrial E3 ubiquitin protein ligase 1 (MUL1), nuclear gene encoding mitochondrial protein
CNY 5,488.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C1orf166; GIDE; MAPL; MULAN; RNF218 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_024544.1
GAGAGTCGGGGGTCACCAGGCCTATCCTTGGCGCCACAGTCGGCCACCGGGGCTCGCCGC
CGTCATGGAGAGCGGAGGGCGGCCCTCGCTGTGCCAGTTCATCCTCCTGGGCACCACCTC TGTGGTCACCGCCGCCCTGTACTCCGTGTACCGGCAGAAGGCCCGGGTCTCCCAAGAGCT CAAGGGAGCTAAAAAAGTTCATTTGGGTGAAGATTTAAAGAGTATTCTTTCAGAAGCTCC AGGAAAATGCGTGCCTTATGCTGTTATAGAAGGAGCTGTGCGGTCTGTTAAAGAAACGCT TAACAGCCAGTTTGTGGAAAACTGCAAGGGGGTAATTCAGCGGCTGACACTTCAGGAGCA CAAGATGGTGTGGAATCGAACCACCCACCTTTGGAATGATTGCTCAAAGATCATTCATCA GAGGACCAACACAGTGCCCTTTGACCTGGTGCCCCACGAGGATGGCGTGGATGTGGCTGT GCGAGTGCTGAAGCCCCTGGACTCAGTGGATCTGGGTCTAGAGACTGTGTATGAGAAGTT CCACCCCTCGATTCAGTCCTTCACCGATGTCATCGGCCACTACATCAGCGGTGAGCGGCC CAAAGGCATCCAAGAGACCGAGGAGATGCTGAAGGTGGGGGCCACCCTCACAGGGGTTGG CGAACTGGTCCTGGACAACAACTCTGTCCGCCTGCAGCCGCCCAAACAAGGCATGCAGTA CTATCTAAGCAGCCAGGACTTCGACAGCCTGCTGCAGAGGCAGGAGTCGAGCGTCAGGCT CTGGAAGGTGCTGGCGCTGGTTTTTGGCTTTGCCACATGTGCCACCCTCTTCTTCATTCT CCGGAAGCAGTATCTGCAGCGGCAGGAGCGCCTGCGCCTCAAGCAGATGCAGGAGGAGTT CCAGGAGCATGAGGCCCAGCTGCTGAGCCGAGCCAAGCCTGAGGACAGGGAGAGTCTGAA GAGCGCCTGTGTAGTGTGTCTGAGCAGCTTCAAGTCCTGCGTCTTTCTGGAGTGTGGGCA CGTTTGTTCCTGCACCGAGTGCTACCGCGCCTTGCCAGAGCCCAAGAAGTGCCCTATCTG CAGACAGGCGATCACCCGGGTGATACCCCTGTACAACAGCTAATAGTTTGGAAGCCGCAC AGCTTGACCTGGAAGCACCCCTGCCCCCTTTTCAGGGATTTTTATCTCGAGGCCTTTGGA GGAGCAGTGGTGGGGGTAGCTGTCACCTCCAGGTATGATTGAGGGAGGAATTGGGTAGAA ACTCTCCAGACCCATGCCTCCAATGGCAGGATGCTGCCTTTCCCACCTGAGAGGGGACCC TGTCCATGTGCAGCCTCATCAGAGCCTCACCCTGGGAGGATGCCGTGGCGTCTCCTCCCA GGAGCCAGATCAGTGCGAGTGTGACTGAAAATGCCTCATCACTTAAGCACCAAAGCCAGT GATCAGCAGCTCTTCTGTTCCTGTGTCTTCTGTTTTTTTCTGGTGAATCGTTGCTTGCTG TGGACTTGGTGGAGGACTCAGAGGGGAGGAAAGGCTGGGCCCCGAGTACAACGGATGCCT TGGGTGCTGCCTCCGAAGAGACTCTGCCGCAGCTTTTCTTCTTTTTCCTCATGCCCCGGG AAACAGTCTTTCTTCAGAATTGTCAGGCTGGGCAGGTCAACTTGTGTTCCTTTCCCCTCA CCTGCTTGCCTCCTTAACGCCTGCACGTGTGTGTAGAGGACAAAAGAAAGTGAAGTCAGC ACATCCGCTTCTGCCCAGATGGTCGGGGCCCCGGGCAACAGATTGAAGAGAGATCATGTG AAGGGCAGTTGGTCAGGCAGGCCTCCTGGTTTCGCCACTGGCCCTGATTTGAACTCCTGC CACTTGGGAGAGCTCGGGGTGGTCCCTGGTTTTCCCTCCTGGAGAATGAGGCGCAGAGGC CTCGCCTCCTGAAGGACGCAGTGTGGATGCCACTGGCCTAGTGTCCTGGCCTCACAGCTT CCTTGCAAGGCTGTCACAAGGAAAAGCAGCCGGCTGGCACCCTGAGCATATGCCCTCTTG GGGCTCCCTCATCCAGCCCGTCGCAGCTTTGACATCTTGGTGTACTCATGTCGCTTCTCC TTGTGTTACCCCCTCCCAGTATTACCATTTGCCCCTCACCTGCCCTTGGTGAGCCTTTTA GTGCAAGACAGATGGGGCTGTTTTCCCCCACCTCTGAGTAGTTGGAGGTCACATACACAG CTCTTTTTTTTATTGCCCTTTTCTGCCTCTGAATGTTCATCTCTCGTCCTCCTTTGTGCA GGCGAGGAAGGGGTGCCCTCAGGGGCCGACACTAGTATGATGCAGTGTCCAGTGTGAACA GCAGAAATTAAACATGTTGCAACCAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_024544 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_024544.1, NP_078820.1 |
| RefSeq Size | 2442 bp |
| RefSeq ORF | 1059 bp |
| Locus ID | 79594 |
| UniProt ID | Q969V5 |
| Protein Families | Druggable Genome, Transmembrane |
| Gene Summary | Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response (PubMed:23399697). Can mediate DDX58 sumoylation and disrupt its polyubiquitination (PubMed:23399697).[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Crosstalk between HSPA5 arginylation and sequential ubiquitination leads to AKT degradation through autophagy flux
,Kim, HJ;Kim, SY;Kim, DH;Park, JS;Jeong, SH;Choi, YW;Kim, CH;,
Autophagy
,PubMed ID 32164484
[MUL1]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204038 | MUL1 (Myc-DDK-tagged)-Human mitochondrial E3 ubiquitin protein ligase 1 (MUL1), nuclear gene encoding mitochondrial protein |
CNY 5,488.00 |
|
| RC204038L1 | Lenti ORF clone of Human mitochondrial E3 ubiquitin protein ligase 1 (MUL1), nuclear gene encoding mitochondrial protein, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC204038L2 | Lenti ORF clone of Human mitochondrial E3 ubiquitin protein ligase 1 (MUL1), nuclear gene encoding mitochondrial protein, mGFP tagged |
CNY 6,180.00 |
|
| RC204038L3 | Lenti ORF clone of Human mitochondrial E3 ubiquitin protein ligase 1 (MUL1), nuclear gene encoding mitochondrial protein, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC204038L4 | Lenti ORF clone of Human mitochondrial E3 ubiquitin protein ligase 1 (MUL1), nuclear gene encoding mitochondrial protein, mGFP tagged |
CNY 7,888.00 |
|
| RG204038 | MUL1 (tGFP-tagged) - Human mitochondrial E3 ubiquitin protein ligase 1 (MUL1), nuclear gene encoding mitochondrial protein |
CNY 7,088.00 |
|
| SC112170 | MUL1 (untagged)-Human mitochondrial E3 ubiquitin protein ligase 1 (MUL1), nuclear gene encoding mitochondrial protein |
CNY 5,488.00 |
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