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MCM6 (NM_005915) Human Untagged Clone
CAT＃: SC323955
MCM6 (untagged)-Human minichromosome maintenance complex component 6 (MCM6)
CNY 6,024.00
CNY 7,220.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | MCG40308; Mis5; P105MCM |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_005915.4
CCACGCGTCCGGTGGCGGTCGAGCGTGGCGTAGGCGAATCCTCGGCACTAAGCATATGGA
CCTCGCGGCGGCAGCGGAGCCGGGCGCCGGCAGCCAGCACCTGGAGGTCCGCGACGAGGT GGCCGAGAAGTGCCAGAAACTGTTCCTGGACTTCTTGGAGGAGTTTCAGAGCAGCGATGG AGAAATTAAATACTTGCAATTAGCAGAGGAACTGATTCGTCCTGAGAGAAACACATTGGT TGTGAGTTTTGTGGACCTGGAACAATTTAACCAGCAACTTTCCACCACCATTCAAGAGGA GTTCTATAGAGTTTACCCTTACCTGTGTCGGGCCTTGAAAACATTCGTCAAAGACCGTAA AGAGATCCCTCTTGCCAAGGATTTTTATGTTGCATTCCAAGACCTGCCTACCAGACACAA GATTCGAGAGCTCACCTCATCCAGAATTGGTTTGCTCACTCGCATCAGTGGGCAGGTGGT GCGGACTCACCCAGTTCACCCAGAGCTTGTGAGCGGAACTTTTCTGTGCTTGGACTGTCA GACAGTGATCAGGGATGTAGAACAGCAGTTCAAATACACACAGCCAAACATCTGCCGAAA TCCAGTTTGTGCCAACAGGAGGAGATTCTTACTGGATACAAATAAATCAAGATTTGTTGA TTTTCAAAAGGTTCGTATTCAAGAGACCCAAGCTGAGCTTCCTCGAGGGAGTATCCCCCG CAGTTTAGAAGTAATTTTAAGGGCTGAAGCTGTGGAATCAGCTCAAGCTGGTGACAAGTG TGACTTTACAGGGACACTGATTGTTGTGCCTGACGTCTCCAAGCTTAGCACACCAGGAGC ACGTGCAGAAACTAATTCCCGTGTCAGTGGTGTTGATGGATATGAGACAGAAGGCATTCG AGGACTCCGGGCCCTTGGTGTTAGGGACCTTTCTTATAGGCTGGTCTTTCTTGCCTGCTG TGTTGCGCCAACCAACCCAAGGTTTGGGGGGAAAGAGCTCAGAGATGAGGAACAGACAGC TGAGAGCATTAAGAACCAAATGACTGTGAAAGAATGGGAGAAAGTGTTTGAGATGAGTCA AGATAAAAATCTATACCACAATCTTTGTACCAGCCTGTTCCCTACTATACATGGCAATGA TGAAGTAAAACGGGGTGTCCTGCTGATGCTCTTTGGTGGCGTTCCAAAGACAACAGGAGA AGGGACCTCTCTTCGAGGGGACATAAATGTTTGCATTGTTGGTGACCCAAGTACAGCTAA GAGCCAATTTCTCAAGCACGTGGAGGAGTTCAGCCCCAGAGCTGTCTACACCAGTGGTAA AGCGTCCAGTGCTGCTGGCTTAACAGCAGCTGTTGTGAGAGATGAAGAATCTCATGAGTT TGTCATTGAGGCTGGAGCTTTGATGTTGGCTGATAATGGTGTGTGTTGTATTGATGAATT TGATAAGATGGACGTGCGGGATCAAGTTGCTATTCATGAAGCTATGGAACAGCAGACCAT ATCCATCACTAAAGCAGGAGTGAAGGCTACTCTGAACGCCCGGACGTCCATTTTGGCAGC AGCAAACCCAATCAGTGGACACTATGACAGATCAAAATCATTGAAACAGAATATAAATTT GTCAGCTCCCATCATGTCCCGATTCGATCTCTTCTTTATCCTTGTGGATGAATGTAATGA GGTTACAGATTATGCCATTGCCAGGCGCATAGTAGATTTGCATTCAAGAATTGAGGAATC AATTGATCGTGTCTATTCCCTCGATGATATCAGAAGATATCTTCTCTTTGCAAGACAGTT TAAACCCAAGATTTCCAAAGAGTCAGAGGACTTCATTGTGGAGCAATATAAACATCTCCG CCAGAGAGATGGTTCTGGAGTGACCAAGTCTTCATGGAGGATTACAGTGCGACAGCTTGA GAGCATGATTCGTCTCTCTGAAGCTATGGCTCGGATGCACTGCTGTGATGAGGTCCAACC TAAACATGTGAAGGAAGCTTTCCGGTTACTGAATAAATCAATCATCCGTGTGGAAACACC TGATGTCAATCTAGATCAAGAGGAAGAGATCCAGATGGAGGTAGATGAGGGTGCCGGTGG CATCAATGGTCATGCTGACAGCCCTGCTCCTGTGAACGGGATCAATGGCTACAATGAAGA CATAAATCAAGAGTCTGCTCCCAAAGCCTCCTTAAGGCTGGGCTTCTCTGAGTACTGCCG AATCTCTAACCTTATTGTGCTTCACCTCAGAAAGGTGGAAGAAGAAGAGGACGAGTCAGC ATTAAAGAGGAGCGAGCTTGTTAACTGGTACTTGAAGGAAATCGAATCAGAGATAGACTC TGAAGAAGAACTTATAAATAAAAAAAGAATCATAGAGAAAGTTATTCATCGACTCACACA CTATGATCATGTTCTAATTGAGCTCACCCAGGCTGGATTGAAAGGCTCCACAGAGGGAAG TGAGAGCTATGAAGAAGATCCCTACTTGGTAGTTAACCCTAACTACTTGCTCGAAGATTG AGATAGTGAAAGTAACTGACCAGAGCTGAGGAACTGTGGCACAGCACCTCGTGGCCTGGA GCCTGGCTGGAGCTCTGCTAGGGACAGAAGTGTTTCTGGAAGTGATGCTTCCAGGATTTG TTTTCAGAAACAAGAATTGAGTTGATGGTCCTATGTGTCACATTCATCACAGGTTTCATA CCAACACAGGCTTCAGCACTTCCTTTGGTGTGTTTCCTGTCCCAGTGAAGTTGGAACCAA ATAATGTGTAGTCTCTATAACCAATACCTTTGTTTTCATGTGTAAGAAAAGGCCCATTAC TTTTAAGGTATGTGCTGTCCTATTGAGCAAATAACTTTTTTTCAATTGCCAGCTACTGCT TTTATTCATCAAAATAAAATAACTTGTTCTGAAGTTGTCTATTGGATTTCTTTCTACTGT ACCCTGATTATTACTTCCATCTACTTCTGAATGTGAGACTTTCCCTTTTTGCTTAACCTG GAGTGAAGAGGTAGAACTGTGGTATTATGGATGAGGTTTCTATGAGAAGGAGTCATTAGA GAACTCATATGAAAGCTAGAGGCCTTAGAGATGACTTTCCAAGGTTAATTCCAGTTTTTT TTTTTTTTAAGTTTATAAAAGTTTATTATACTTTTTTAAAATTACTCTTTAGTAATTTAT TTTACTTCTGTGTCCTAAGGGTAATTTCTCAGGATTGTTTTCAAATTGCTTTTTTAGGGG AAATAGGTCATTTGCTATATTACAAGCAATCCCCAAATTTTATGGTCTTCCAGGAAAAGT TATTACCGTTTATGATACTAACAGTTCCTGAGACTTAGCTATGATCAGTATGTTCATGAG GTGGAGCAGTTCCTGTGTTGCAGCTTTTAACAACAGATGGCATTCATTAAATCACAAAGT ATGTTAAAGGTCACAAAAGCAAAATAACTGTCTGAGGCTAAGGCCCACGTGGGACAGTCT AATACCCATGAGTACTCAACTTGCCTTGATGTCTGAGCTTTCCAGTGCAATGTGAATTTG AGCAGCCAGAAATCTATTAGTAGAAAGCAAGACAGATTAATATAGGTTAAAACAATGATT TAAATATGTTTCTCCCAATAATTATCTCTTTCCCTGGAATCAACTTGTATGAAACCTTGT CAAAATGTACTCCACAAGTATGTACAATTAAGTATTTTAAAAATAAATGGCAAACATTAA AAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | ECoRI-NOT |
| ACCN | NM_005915 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005915.4, NP_005906.2 |
| RefSeq Size | 3769 bp |
| RefSeq ORF | 2466 bp |
| Locus ID | 4175 |
| UniProt ID | Q14566 |
| Domains | MCM |
| Protein Families | Stem cell - Pluripotency, Transcription Factors |
| Protein Pathways | Cell cycle, DNA replication |
| Gene Summary | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Complete In Vitro Reconstitution of Adeno-Associated Virus DNA Replication Requires the Minichromosome Maintenance Complex Proteins
,Kevin Nash, Weijun Chen, and Nicholas Muzyczka,
J. Virol., Feb 2008; 82: 1458 - 1464.
[MCM6]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC207097 | MCM6 (Myc-DDK-tagged)-Human minichromosome maintenance complex component 6 (MCM6) |
CNY 6,016.00 |
|
| RC207097L1 | Lenti ORF clone of Human minichromosome maintenance complex component 6 (MCM6), Myc-DDK-tagged |
CNY 8,416.00 |
|
| RC207097L2 | Lenti ORF clone of Human minichromosome maintenance complex component 6 (MCM6), mGFP tagged |
CNY 7,700.00 |
|
| RC207097L3 | Lenti ORF clone of Human minichromosome maintenance complex component 6 (MCM6), Myc-DDK-tagged |
CNY 7,700.00 |
|
| RC207097L4 | Lenti ORF clone of Human minichromosome maintenance complex component 6 (MCM6), mGFP tagged |
CNY 7,700.00 |
|
| RG207097 | MCM6 (tGFP-tagged) - Human minichromosome maintenance complex component 6 (MCM6) |
CNY 6,370.00 |
|
| SC110945 | MCM6 (untagged)-Human minichromosome maintenance complex component 6 (MCM6) |
CNY 6,024.00 |
