PRMT2 (NM_001242864) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	HRMT1L1
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC330036 representing NM_001242864. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGCAACATCAGGTGACTGTCCCAGAAGTGAATCGCAGGGAGAAGAGCCTGCTGAGTGCAGTGAGGCC GGTCTCCTGCAGGAGGGAGTACAGCCAGAGGAGTTTGTGGCCATCGCGGACTACGCTGCCACCGATGAG ACCCAGCTCAGTTTTTTGAGAGGAGAAAAAATTCTTATCCTGAGACAAACCACTGCAGATTGGTGGTGG GGTGAGCGTGCGGGCTGCTGTGGGTACATTCCGGCAAACCATGTGGGGAAGCACGTGGATGAGTACGAC CCCGAGGACACGTGGCAGGATGAAGAGTACTTCGGCAGCTATGGAACTCTGAAACTCCACTTGGAGATG TTGGCAGACCAGCCACGAACAACTAAATACCACAGTGTCATCCTGCAGAATAAAGAATCCCTGACGGAT AAAGTCATCCTGGACGTGGGCTGTGGGACTGGGATCATCAGTCTCTTCTGTGCACACTATGCGCGGCCT AGAGCGGTGTACGCGGTGGAGGCCAGTGAGATGGCACAGCACACGGGGCAGCTGGTCCTGCAGAACGGC TTTGCTGACATCATCACCGTGTACCAGCAGAAGGTGGAGGATGTGGTGCTGCCCGAGAAGGTGGACGTG CTGGTGTCTGAGTGGATGGGGACCTGCCTGCTGACCCTGAGGGGCGAGCTGCGCTTCGACATCAGGAAG GCGGGGACCCTGCACGGCTTCACGGCCTGGTTTAGCGTCCACTTCCAGAGCCTGCAGGAGGGGCAGCCG CCGCAGGTGCTCAGCACCGGGCCCTTCCACCCCACCACACACTGGAAGCAGACGCTGTTCATGATGGAC GACCCAGTCCCTGTCCATACAGGAGACGTGGTCACGGGTTCAGTTGTGTTGCAGAGAAACCCAGTGTGG AGAAGGCACATGTCTGTGGCTCTGAGCTGGGCTGTCACTTCCAGACAAGACCCCACATCTCAAAAAGTT GGAGAAAAAGTCTTCCCCATCTGGAGATGA
Restriction Sites	SgfI-MluI
ACCN	NM_001242864
Insert Size	996 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001242864.2
RefSeq Size	2031 bp
RefSeq ORF	996 bp
Locus ID	3275
UniProt ID	P55345
Protein Families	Druggable Genome
MW	37.2 kDa
Gene Summary	Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (3) differs in the 5' UTR and lacks 2 consecutive exons in the 3' coding region compared to variant 1. However, it maintains the reading frame and encodes a shorter isoform (2) lacking an internal protein segment compared to isoform 1.

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