Leptin Receptor (LEPR) (NM_001198687) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CD295; LEP-R; LEPRD; OB-R; OBR
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC331218 representing NM_001198687. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGATTTGTCAAAAATTCTGTGTGGTTTTGTTACATTGGGAATTTATTTATGTGATAACTGCGTTTAAC TTGTCATATCCAATTACTCCTTGGAGATTTAAGTTGTCTTGCATGCCACCAAATTCAACCTATGACTAC TTCCTTTTGCCTGCTGGACTCTCAAAGAATACTTCAAATTCGAATGGACATTATGAGACAGCTGTTGAA CCTAAGTTTAATTCAAGTGGTACTCACTTTTCTAACTTATCCAAAACAACTTTCCACTGTTGCTTTCGG AGTGAGCAAGATAGAAACTGCTCCTTATGTGCAGACAACATTGAAGGAAAGACATTTGTTTCAACAGTA AATTCTTTAGTTTTTCAACAAATAGATGCAAACTGGAACATACAGTGCTGGCTAAAAGGAGACTTAAAA TTATTCATCTGTTATGTGGAGTCATTATTTAAGAATCTATTCAGGAATTATAACTATAAGGTCCATCTT TTATATGTTCTGCCTGAAGTGTTAGAAGATTCACCTCTGGTTCCCCAAAAAGGCAGTTTTCAGATGGTT CACTGCAATTGCAGTGTTCATGAATGTTGTGAATGTCTTGTGCCTGTGCCAACAGCCAAACTCAACGAC ACTCTCCTTATGTGTTTGAAAATCACATCTGGTGGAGTAATTTTCCAGTCACCTCTAATGTCAGTTCAG CCCATAAATATGGTGAAGCCTGATCCACCATTAGGTTTGCATATGGAAATCACAGATGATGGTAATTTA AAGATTTCTTGGTCCAGCCCACCATTGGTACCATTTCCACTTCAATATCAAGTGAAATATTCAGAGAAT TCTACAACAGTTATCAGAGAAGCTGACAAGATTGTCTCAGCTACATCCCTGCTAGTAGACAGTATACTT CCTGGGTCTTCGTATGAGGTTCAGGTGAGGGGCAAGAGACTGGATGGCCCAGGAATCTGGAGTGACTGG AGTACTCCTCGTGTCTTTACCACACAAGATGTCATATACTTTCCACCTAAAATTCTGACAAGTGTTGGG TCTAATGTTTCTTTTCACTGCATCTATAAGAAGGAAAACAAGATTGTTCCCTCAAAAGAGATTGTTTGG TGGATGAATTTAGCTGAGAAAATTCCTCAAAGCCAGTATGATGTTGTGAGTGATCATGTTAGCAAAGTT ACTTTTTTCAATCTGAATGAAACCAAACCTCGAGGAAAGTTTACCTATGATGCAGTGTACTGCTGCAAT GAACATGAATGCCATCATCGCTATGCTGAATTATATGTGATTGATGTCAATATCAATATCTCATGTGAA ACTGATGGGTACTTAACTAAAATGACTTGCAGATGGTCAACCAGTACAATCCAGTCACTTGCGGAAAGC ACTTTGCAATTGAGGTATCATAGGAGCAGCCTTTACTGTTCTGATATTCCATCTATTCATCCCATATCT GAGCCCAAAGATTGCTATTTGCAGAGTGATGGTTTTTATGAATGCATTTTCCAGCCAATCTTCCTATTA TCTGGCTACACAATGTGGATTAGGATCAATCACTCTCTAGGTTCACTTGACTCTCCACCAACATGTGTC CTTCCTGATTCTGTGGTGAAGCCACTGCCTCCATCCAGTGTGAAAGCAGAAATTACTATAAACATTGGA TTATTGAAAATATCTTGGGAAAAGCCAGTCTTTCCAGAGAATAACCTTCAATTCCAGATTCGCTATGGT TTAAGTGGAAAAGAAGTACAATGGAAGATGTATGAGGTTTATGATGCAAAATCAAAATCTGTCAGTCTC CCAGTTCCAGACTTGTGTGCAGTCTATGCTGTTCAGGTGCGCTGTAAGAGGCTAGATGGACTGGGATAT TGGAGTAATTGGAGCAATCCAGCCTACACAGTTGTCATGGATATAAAAGTTCCTATGAGAGGACCTGAA TTTTGGAGAATAATTAATGGAGATACTATGAAAAAGGAGAAAAATGTCACTTTACTTTGGAAGCCCCTG ATGAAAAATGACTCATTGTGCAGTGTTCAGAGATATGTGATAAACCATCATACTTCCTGCAATGGAACA TGGTCAGAAGATGTGGGAAATCACACGAAATTCACTTTCCTGTGGACAGAGCAAGCACATACTGTTACG GTTCTGGCCATCAATTCAATTGGTGCTTCTGTTGCAAATTTTAATTTAACCTTTTCATGGCCTATGAGC AAAGTAAATATCGTGCAGTCACTCAGTGCTTATCCTTTAAACAGCAGTTGTGTGATTGTTTCCTGGATA CTATCACCCAGTGATTACAAGCTAATGTATTTTATTATTGAGTGGAAAAATCTTAATGAAGATGGTGAA ATAAAATGGCTTAGAATCTCTTCATCTGTTAAGAAGTATTATATCCATGATCATTTTATCCCCATTGAG AAGTACCAGTTCAGTCTTTACCCAATATTTATGGAAGGAGTGGGAAAACCAAAGATAATTAATAGTTTC ACTCAAGATGATATTGAAAAACACCAGAGTGATGCAGGTTTATATGTAATTGTGCCAGTAATTATTTCC TCTTCCATCTTATTGCTTGGAACATTATTAATATCACACCAAAGAATGAAAAAGCTATTTTGGGAAGAT GTTCCGAACCCCAAGAATTGTTCCTGGGCACAAGGACTTAATTTTCAGAAGATGCTTGAAGGCAGCATG TTCGTTAAGAGTCATCACCACTCCCTAATCTCAAGTACCCAGGGACACAAACACTGCGGAAGGCCACAG GGTCCTCTGCATAGGAAAACCAGAGACCTTTGTTCACTTGTTTATCTGCTGACCCTCCCTCCACTATTG TCCTATGACCCTGCCAAATCCCCCTCTGTGAGAAACACCCAAGAATGA
Restriction Sites	SgfI-MluI
ACCN	NM_001198687
Insert Size	2877 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001198687.1
RefSeq Size	3044 bp
RefSeq ORF	2877 bp
Locus ID	3953
UniProt ID	P48357
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Adipocytokine signaling pathway, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Neuroactive ligand-receptor interaction
MW	109.4 kDa
Gene Summary	The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010] Transcript Variant: This variant (4) contains alternate 5' UTR and 3' terminal exon compared to variant 1, resulting in a shorter isoform (2) with a distinct C-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform.

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