RGS6 (NM_001204424) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	GAP; HA117; S914
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC331584 representing NM_001204424. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGCTCAAGGATCCGGGGATCAAAGAGCAGTGGGGGTTGCTGACCCAGAGGAGAGTTCTCCAAACATG ATCGTTTACTGCAAAATTGAAGACATCATTACAAAGATGCAAGATGACAAGACAGGGGGTGTGCCCATC AGAACAGTCAAGAGCTTTCTCTCCAAAATCCCCAGTGTCGTCACAGGTACTGACATTGTGCAGTGGCTT ATGAAGAACCTTTCCATTGAGGACCCAGTTGAAGCAATACACTTGGGGAGCCTTATCGCTGCCCAGGGC TACATCTTTCCAATCTCAGACCATGTTCTCACCATGAAGGATGATGGCACCTTTTATCGTTTCCAGGCT CCGTACTTCTGGCCTTCGAACTGCTGGGAACCTGAAAACACTGACTATGCCATCTATCTCTGTAAGAGG ACAATGCAAAATAAAGCAAGGCTGGAACTGGCAGATTATGAAGCAGAAAACTTAGCAAGACTCCAGAGG GCCTTTGCGAGGAAGTGGGAATTCATCTTTATGCAAGCAGAAGCACAAGTAAAGATTGACCGGAAAAAA GACAAGACAGAAAGGAAAATTTTGGATAGTCAAGAACGAGCCTTTTGGGATGTCCACAGGCCTGTGCCA GGCTGTGTGAACACAACAGAAATGGATATCCGAAAATGTCGACGTTTGAAGAATCCACAAAAGGTTAAA AAGTCCGTGTATGGCGTGACTGAAGAGTCCCAGGCACAGAGCCCGGTGCATGTACTCAGCCAACCAATC AGGAAAACAACAAAAGAGGACATCCGGAAACAGATAACATTTTTGAACGCACAGATCGACAGACATTGT TTGAAAATGTCCAAAGTGGCTGAAAGTTTAATTGCCTACACGGAACAATATGTGGAATATGACCCTTTG ATAACACCAGCTGAGCCATCCAACCCTTGGATCAGCGATGACGTTGCTTTGTGGGACATAGAGATGAGC AAAGAGCCCAGCCAACAGCGAGTAAAAAGATGGGGCTTCTCTTTCGATGAGATATTGAAGGACCAGGTG GGGCGGGACCAGTTTCTACGATTCCTGGAGTCCGAATTCAGTTCAGAAAACCTCAGGTTCTGGCTGGCT GTCCAAGATCTTAAGAAACAACCCCTACAGGATGTGGCCAAGAGGGTAGAAGAAATCTGGCAAGAGTTT CTGGCTCCAGGGGCTCCAAGTGCAATCAACCTGGATTCTCACAGCTATGAGATAACCAGTCAAAATGTC AAAGATGGAGGGAGATATACATTTGAAGACGCCCAGGAGCACATCTACAAGCTGATGAAGAGTGACAGC TATGCCCGCTTCCTCCGGTCAAATGCTTACCAGGATTTGCTGCTGGCCAAGAAGAAGCCAGAAAGTGAG CAAGGTCGTAGAACTTCCCTAGAAAAGTTCACTCGCAGTGTGGGAAAGTCGCTGGCGGGCAAGCGCCTC ACGGGCCTGATGCAGTCCTCCTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001204424
Insert Size	1473 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001204424.1
RefSeq Size	6073 bp
RefSeq ORF	1473 bp
Locus ID	9628
UniProt ID	P49758
Protein Families	Druggable Genome
MW	56.5 kDa
Gene Summary	This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011] Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1 and 10 encode the same isoform (1).

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