ADAM15 (NM_001261465) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	MDC15
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC332792 representing NM_001261465. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGCGGCTGGCGCTGCTCTGGGCCCTGGGGCTCCTGGGCGCGGGCAGCCCTCTGCCTTCCTGGCCGCTC CCAAATATAGGTGGCACTGAGGAGCAGCAGGCAGAGTCAGAGAAGGCCCCGAGGGAGCCCTTGGAGCCC CAGGTCCTTCAGGACGATCTCCCAATTAGCCTCAAAAAGGTGCTTCAGACCAGTCTGCCTGAGCCCCTG AGGATCAAGTTGGAGCTGGACGGTGACAGTCATATCCTGGAGCTGCTACAGAATAGGGAGTTGGTCCCA GGCCGCCCAACCCTGGTGTGGTACCAGCCCGATGGCACTCGGGTGGTCAGTGAGGGACACACTTTGGAG AACTGCTGCTACCAGGGAAGAGTGCGGGGATATGCAGGCTCCTGGGTGTCCATCTGCACCTGCTCTGGG CTCAGAGGCTTGGTGGTCCTGACCCCAGAGAGAAGCTATACCCTGGAGCAGGGGCCTGGGGACCTTCAG GGTCCTCCCATTATTTCGCGAATCCAAGATCTCCACCTGCCAGGCCACACCTGTGCCCTGAGCTGGCGG GAATCTGTACACACTCAGAAGCCACCAGAGCACCCCCTGGGACAGCGCCACATTCGCCGGAGGCGGGAT GTGGTAACAGAGACCAAGACTGTGGAGTTGGTGATTGTGGCTGATCACTCGGAGGCCCAGAAATACCGG GACTTCCAGCACCTGCTAAACCGCACACTGGAAGTGGCCCTCTTGCTGGACACATTCTTCCGGCCCCTG AATGTACGAGTGGCACTAGTGGGCCTGGAGGCCTGGACCCAGCGTGACCTGGTGGAGATCAGCCCAAAC CCAGCTGTCACCCTCGAAAACTTCCTCCACTGGCGCAGGGCACATTTGCTGCCTCGATTGCCCCATGAC AGTGCCCAGCTGGTGACTGGTACTTCATTCTCTGGGCCTACGGTGGGCATGGCCATTCAGAACTCCATC TGTTCTCCTGACTTCTCAGGAGGTGTGAACATGGACCACTCCACCAGCATCCTGGGAGTCGCCTCCTCC ATAGCCCATGAGTTGGGCCACAGCCTGGGCCTGGACCATGATTTGCCTGGGAATAGCTGCCCCTGTCCA GGTCCAGCCCCAGCCAAGACCTGCATCATGGAGGCCTCCACAGACTTCCTACCAGGCCTGAACTTCAGC AACTGCAGCCGACGGGCCCTGGAGAAAGCCCTCCTGGATGGAATGGGCAGCTGCCTCTTCGAACGGCTG CCTAGCCTACCCCCTATGGCTGCTTTCTGCGGAAATATGTTTGTGGAGCCGGGCGAGCAGTGTGACTGT GGCTTCCTGGATGACTGCGTCGATCCCTGCTGTGATTCTTTGACCTGCCAGCTGAGGCCAGGTGCACAG TGTGCATCTGACGGACCCTGTTGTCAAAATTGCCAGCTGCGCCCGTCTGGCTGGCAGTGTCGTCCTACC AGAGGGGATTGTGACTTGCCTGAATTCTGCCCAGGAGACAGCTCCCAGTGTCCCCCTGATGTCAGCCTA GGGGATGGCGAGCCCTGCGCTGGCGGGCAAGCTGTGTGCATGCACGGGCGTTGTGCCTCCTATGCCCAG CAGTGCCAGTCACTTTGGGGACCTGGAGCCCAGCCCGCTGCGCCACTTTGCCTCCAGACAGCTAATACT CGGGGAAATGCTTTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCTAGAGAT GCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTAGGACCCAGCCTCTGCTGGGCTCCATCCGGGATCTA CTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGCTGGGTGCACCTGGACCTGGGCAGT GATGTGGCCCAGCCCCTCCTGACTCTGCCTGGCACAGCCTGTGGCCCTGGCCTGGTGTGTATAGACCAT CGATGCCAGCGTGTGGATCTCCTGGGGGCACAGGAATGTCGAAGCAAATGCCATGGACATGGGGTCTGT GACAGCAACAGGCACTGCTACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTCAGCTCAAAGCA ACCAGCTCCCTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCC AGCTACTGGTACCGTGCCCGCCTGCACCAGCGACTCTGCCAGCTCAAGGGACCCACCTGCCAGTACAGG CTAGTGCTCTCAGCTTCCCGGCCCCCCCTTCCAGGCCGCTGCCGCCTGACCCTGTGTCCAAGAGACTCC AGTCTCAGGGGCCAGCCAAGCCCCCACCCCCAAGGAAGCCACTGCCTGCCGACCCCCAGGGCCGGTGCC CATCGGGTGACCTGCCCGGCCCAGGGGCTGGAATCCCGCCCCTAG
Restriction Sites	SgfI-MluI
ACCN	NM_001261465
Insert Size	2391 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001261465.1
RefSeq Size	2854 bp
RefSeq ORF	2391 bp
Locus ID	8751
UniProt ID	Q13444
Protein Families	Druggable Genome, Protease, Transmembrane
MW	86.3 kDa
Gene Summary	The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (8) lacks two alternate in-frame exons in the 3' coding region compared to variant 6. The resulting protein (isoform 8) is shorter compared to isoform 6.

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