AP3D1 (NM_001261826) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	ADTD; hBLVR; HPS10
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC332796 representing NM_001261826. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGCCCTCAAGATGGTGAAGGGCAGCATCGACCGCATGTTCGACAAGAATCTGCAGGACTTGGTCCGC GGCATCCGTAACCACAAGGAGGACGAGGCAAAATACATATCTCAGTGCATTGATGAGATCAAGCAGGAG CTGAAGCAGGACAACATAGCGGTGAAGGCGAACGCGGTCTGCAAGCTGACGTATTTACAGATGTTGGGA TACGACATCAGCTGGGCCGCCTTCAACATCATAGAAGTGATGAGTGCCTCCAAGTTCACCTTCAAGCGA ATTGGCTACCTCGCTGCTTCCCAGAGCTTTCACGAAGGCACCGACGTCATCATGCTGACCACCAATCAG ATCCGTAAGGACTTGAGCAGCCCCAGCCAGTACGACACAGGTGTTGCACTGACGGGTCTGTCCTGCTTC GTCACCCCAGACCTTGCCAGAGACCTGGCAAATGACATCATGACACTGATGTCACACACCAAGCCCTAC ATCAGGAAGAAGGCTGTGCTGATCATGTACAAGGTGTTCCTGAAGTACCCCGAGTCGCTGCGCCCTGCC TTTCCCCGGCTGAAGGAGAAGCTGGAGGACCCCGACCCCGGGGTTCAGTCGGCTGCCGTCAATGTCATC TGCGAGCTGGCCAGACGCAACCCTAAGAACTACCTGTCCCTGGCCCCGCTCTTTTTCAAGCTGATGACG TCCTCCACCAACAACTGGGTCCTCATCAAGATCATCAAGCTGTTCGGTGCTCTTACTCCTTTGGAACCG CGGCTGGGCAAGAAGCTGATCGAGCCCCTCACCAATCTCATCCACAGCACGTCTGCCATGTCTCTCCTC TATGAATGTGTGAACACCGTGATTGCAGTGCTCATCTCGCTGTCCTCCGGCATGCCCAACCACAGCGCC AGCATCCAGCTTTGTGTTCAGAAATTAAGGATATTGATCGAGGACTCCGATCAGAACTTGAAGTACCTG GGGCTGCTGGCAATGTCCAAGATCCTGAAGACCCACCCCAAGTCCGTGCAGTCCCACAAGGACCTCATC CTGCAGTGCCTGGACGACAAGGACGAGTCCATCCGGCTGCGGGCCCTGGACCTGCTCTATGGGATGGTG TCCAAGAAGAACCTGATGGAGATCGTGAAGAAGCTGATGACCCACGTAGACAAGGCAGAGGGTACCACC TACCGTGACGAGCTGCTCACCAAGATCATTGACATCTGCAGCCAGTCCAACTACCAGTACATCACCAAC TTCGAGTGGTACATCAGCATCCTGGTGGAGCTGACCCGGCTGGAGGGCACACGGCACGGCCACCTCATC GCCGCCCAAATGCTGGACGTGGCCATCCGCGTGAAGGCCATCCGCAAGTTCGCCGTGTCCCAGATGTCT GCGCTGCTTGACAGTGCACACCTGCTGGCCAGCAGCACCCAGCGGAACGGGATCTGTGAGGTGCTGTAC GCTGCCGCCTGGATCTGCGGGGAGTTCTCAGAGCATCTGCAGGAACCACACCACACTTTGGAGGCCATG CTGCGGCCCAGAGTCACCACGCTGCCAGGCCACATCCAGGCCGTGTATGTGCAGAACGTGGTCAAGCTC TACGCCTCCATCCTGCAGCAGAAGGAGCAGGCCGGGGAGGCAGAGGGCGCTCAGGCCGTCACCCAGCTC ATGGTGGACCGGCTGCCCCAGTTTGTGCAGAGCGCAGACCTGGAGGTGCAGGAGCGGGCGTCCTGCATC CTGCAGCTGGTCAAGCACATCCAGAAGCTTCAGGCCAAGGACGTGCCTGTGGCAGAGGAGGTCAGCGCT CTCTTTGCTGGGGAGCTGAACCCAGTGGCCCCCAAGGCCCAGAAGAAGGTTCCAGTCCCCGAAGGCCTG GACCTGGACGCCTGGATCAATGAGCCACTCTCGGACAGCGAGTCAGAGGACGAGAGGCCCAGGGCCGTC TTCCACGAGGAGGAGCAGCGGCGTCCCAAGCACCGGCCGTCGGAGGCGGACGAGGAAGAGCTGGCTCGG CGCCGAGAGGCCCGGAAGCAGGAGCAGGCCAACAACCCCTTCTACATCAAGAGCTCGCCATCGCCACAG AAGCGGTACCAGGACACCCCGGGCGTGGAGCACATTCCCGTGGTGCAGATTGACCTCTCCGTCCCCTTG AAGGTTCCAGGGCTGCCTATGTCAGATCAGTATGTGAAGCTGGAGGAGGAGCGGCGGCACCGGCAGAAG CTGGAGAAGGACAAGAGGAGGAAAAAGAGGAAGGAGAAGGAGAAGAAGGGCAAGCGCCGCCACAGCTCG CTGCCCACGGAGAGCGACGAGGACATCGCCCCTGCCCAGCAGGTGGACATCGTCACAGAGGAGATGCCT GAGAATGCTCTGCCCAGCGACGAGGATGACAAAGACCCCAACGACCCCTACAGGGCTCTGGATATTGAC CTGGATAAGCCCTTAGCCGACAGCGAGAAACTGCCTATTCAGAAACACAGAAACACCGAGACCTCAAAA TCCCCTGAGAAGGACGTTCCCATGGTAGAAAAGAAGAGCAAGAAACCCAAGAAGAAAGAGAAAAAACAC AAAGAGAAAGAGAGAGACAAGGAGAAGAAGAAGGAGAAGGAGAAGAAGGCTGAGGACCTGGACTTCTGG CTGTCTACCACCCCACCGCCTGCCCCCGCCCCCGCCCCCGCCCCCGTTCCATCCACGGGGGAGCTCAGT GTGAACACTGTCACTACCCCGAAGGACGAGTGTGAGGACGCCAAGACGGAGGCGCAGGGCGAGGAGGAC GATGCCGAGGGGCAAGACCAGGACAAGAAATCTCCCAAGCCTAAGAAGAAGAAGCACAGGAAGGAGAAG GAGGAGCGGACCAAAGGCAAGAAGAAGTCCAAGAAGCAGCCTCCAGGCAGCGAGGAGGCAGCGGGGGAG CCGGTGCAGAATGGCGCGCCAGAGGAGGAGCAGCTCCCGCCTGAGTCCAGCTACTCCCTCCTCGCTGAA AATTCCTATGTTAAAATGACCTGTGACATCCGGGGCAGTCTGCAGGAGGACAGCCAGGTCACTGTGGCC ATCGTGCTGGAGAACAGGAGCAGCAGCATCCTCAAGGGCATGGAGCTCAGCGTGCTGGACTCACTCAAT GCCAGGATGGCCCGGCCGCAGGGCTCCTCCGTCCACGATGGCGTCCCCGTGCCTTTCCAGCTGCCCCCA GGCGTCTCCAACGAAGCCCAGTATGTGTTCACCATCCAGAGCATCGTCATGGCGCAGAAGCTCAAGGGG ACCCTGTCCTTCATTGCCAAGAATGACGAGGGTGCGACCCACGAGAAGCTGGACTTCAGGCTGCACTTC AGCTGCAGCTCCTACTTGATCACCACTCCCTGCTACAGTGACGCCTTTGCTAAGTTGCTGGAGTCTGGG GACTTGAGCATGAGCTCAATCAAAGTCGATGGCATTCGGATGTCCTTCCAGAATCTTCTGGCGAAGATC TGTTTTCACCACCATTTTTCCGTTGTGGAGCGAGTGGACTCCTGCGCCTCCATGTACAGCCGCTCCATC CAGGGCCACCATGTCTGCCTCCTGGTGAAAAAGGGTGAGAACTCTGTCTCAGTCGACGGGAAGTGCAGT GACTCCACGCTACTGAGCAACTTGTTAGAAGAGATGAAGGCGACGCTGGCCAAGTGTTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001261826
Insert Size	3648 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001261826.1
RefSeq Size	5073 bp
RefSeq ORF	3648 bp
Locus ID	8943
UniProt ID	O14617
Protein Families	Druggable Genome
Protein Pathways	Lysosome
MW	136.7 kDa
Gene Summary	The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. Defects in this gene are a cause of a new type of Hermansky-Pudlak syndrome. [provided by RefSeq, Feb 2017] Transcript Variant: This variant (3) encodes the longer isoform (3).

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