DRIP130 (MED23) (NM_001270522) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	ARC130; CRSP3; CRSP130; CRSP133; DRIP130; MRT18; SUR-2; SUR2
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC332965 representing NM_001270522. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGAGACGCAACTGCAGAGCATTTTCGAAGAGGTGGTGAAAACGGAAGTTATAGAAGAGGCTTTTCCT GGCATGTTTATGGATACTCCTGAAGATGAGAAAACAAAACTAATTAGCTGTTTGGGGGCCTTCAGACAG TTTTGGGGTGGTCTTTCTCAGGAGTCTCATGAACAGTGTATCCAGTGGATTGTTAAGTTTATTCATGGT CAGCATAGTCCTAAAAGAATTTCTTTTCTTTATGACTGCTTAGCAATGGCAGTTGAGACTGGTCTCCTT CCACCCAGGCTGGTTTGTGAATCCCTGATAAACTCTGACACTCTTGAGTGGGAAAGAACACAGCTTTGG GCCTTAACATTTAAACTGGTTCGGAAAATAATTGGGGGAGTGGATTACAAGGGTGTTCGAGATCTCTTA AAAGTGATTTTGGAGAAGATTTTGACAATTCCTAATACAGTGAGCTCTGCTGTTGTACAGCAGCTTCTG GCAGCAAGAGAGGTTATAGCATATATCTTGGAAAGAAATGCCTGCTTATTACCAGCCTATTTTGCAGTC ACTGAGATCAGGAAACTGTATCCTGAAGGCAAACTTCCACACTGGTTACTTGGAAACCTAGTATCAGAC TTTGTGGATACCTTCAGGCCCACAGCAAGGATAAACTCCATTTGTGGTCGCTGTAGTCTTCTGCCAGTT GTAAATAATTCGGGTGCCATTTGTAATTCATGGAAACTGGATCCTGCTACTCTTCGTTTTCCTTTGAAA GGCCTTTTGCCATATGATAAGGATCTGTTTGAACCACAGACTGCTTTGTTGAGATATGTATTGGAGCAG CCTTATTCCAGGGATATGGTCTGCAATATGCTAGGTTTAAATAAGCAGCACAAGCAGCGCTGCCCTGTG CTGGAGGACCAGTTGGTGGATCTGGTTGTTTATGCCATGGAGCGATCTGAGACCGAGGAGAAGTTTGAC GATGGGGGAACAAGCCAACTCCTGTGGCAGCATCTCTCAAGTCAGCTCATTTTCTTTGTGCTTTTCCAG TTTGCAAGTTTTCCACATATGGTGCTTTCTCTTCATCAGAAGTTAGCAGGGCGAGGACTGATTAAAGGC AGAGATCATCTTATGTGGGTTCTCCTGCAATTCATTTCTGGAAGTATTCAGAAAAATGCACTAGCTGAT TTTCTCCCTGTGATGAAGCTCTTCGACTTGCTATACCCAGAAAAAGAATATATCCCAGTTCCTGATATT AACAAACCCCAGTCAACCCATGCCTTTGCAATGACCTGTATTTGGATTCATCTCAATAGAAAAGCTCAA AATGACAACTCCAAGCTACAGATTCCAATACCTCATTCCCTAAGACTTCACCATGAGTTCCTGCAGCAG AGTCTAAGAAATAAAAGTTTACAGATGAATGACTATAAGATTGCTCTATTGTGTAATGCATACTCTACA AATTCAGAATGTTTTACATTACCCATGGGAGCTCTGGTAGAAACTATTTATGGAAATGGAATTATGAGG ATACCTCTCCCTGGAACAAACTGTATGGCTTCAGGATCTATTACCCCCTTACCTATGAACCTCCTGGAT TCACTGACAGTTCATGCCAAAATGAGCCTTATTCACAGCATTGCAACCAGGGTGATAAAACTTGCTCAT GCAAAGTCCAGTGTGGCCTTGGCTCCAGCCCTAGTGGAAACTTACAGTCGTTTATTGGTCTATATGGAA ATAGAGTCTTTGGGCATCAAAGGATTTATCAGTCAGCTTTTGCCAACTGTTTTCAAATCACATGCATGG GGGATCTTACACACACTCCTTGAGATGTTTAGCTACCGGATGCATCATATTCAGCCTCATTACAGAGTT CAGCTCCTGAGTCATCTTCATACTTTGGCTGCAGTTGCACAAACAAACCAGAACCAGCTCCATCTTTGT GTCGAGAGCACTGCTCTCAGGCTTATAACAGCATTAGGTAGCTCAGAGGTACAACCGCAGTTTACACGC TTCCTTAGTGATCCCAAAACAGTGCTCTCAGCAGAATCTGAAGAACTGAACCGAGCCTTGATATTGACC TTGGCTAGAGCAACTCATGTAACAGATTTTTTTACAGGCTCTGATTCAATTCAGGGAACTTGGTGTAAA GACATACTTCAGACCATCATGAGTTTCACTCCTCATAATTGGGCTTCACACACCCTGAGCTGTTTTCCA GGCCCACTACAGGCATTCTTCAAACAAAATAATGTGCCTCAGGAAAGCCGTTTTAATCTGAAAAAAAAT GTGGAGGAGGAGTATAGGAAGTGGAAGTCAATGAGCAACGAAAACGACATTATTACCCACTTCTCTATG CAGGGCTCCCCTCCTCTCTTTCTTTGTCTTCTCTGGAAAATGCTCTTGGAAACAGATCATATTAATCAG ATTGGCTATAGAGTATTAGAGAGAATTGGAGCCAGGGCCTTGGTAGCCCATGTGAGGACATTTGCAGAT TTCCTGGTATATGAGTTTTCTACATCAGCAGGGGGTCAGCAACTCAATAAATGCATTGAAATTCTTAAT GACATGGTATGGAAGTATAACATTGTTACACTGGACAGATTAATTCTCTGCCTGGCCATGCGTAGTCAC GAAGGAAATGAAGCCCAGGTTTGTTATTTCATAATTCAGTTGCTGTTACTCAAACCAAACGATTTTAGA AATCGAGTAAGTGACTTTGTGAAGGAAAATTCCCCAGAGCACTGGTTACAGAATGACTGGCACACCAAG CACATGAATTATCACAAGAAATATCCAGAGAAGTTGTATTTTGAGGGCCTCGCGGAACAGGTGGATCCT CCTGTACAGATCCAGTCTCCCTATCTGCCCATCTATTTTGGGAATGTGTGTCTTCGATTCCTTCCAGTA TTTGATATAGTAATCCACAGATTTTTAGAGTTGCTTCCGGTATCCAAATCACTGGAGACTCTACTGGAT CATCTAGGAGGCTTATATAAATTTCATGATCGTCCAGTGACTTATCTGTATAACACTCTGCACTATTAT GAAATGCACCTGAGAGACCGCGCATTTCTCAAACGAAAACTCGTCCATGCGATCATTGGCTCTCTGAAG GATAATCGACCGCAGGGCTGGTGTCTAAGTGACACTTACCTGAAATGCGCTATGAATGCACGAGAGGAA AATCCTTGGGTTCCAGATGACACCTACTATTGCAGATTGATTGGCAGACTAGTCGATACGATGGCTGGC AAATCTCCTGGTCCCTTTCCAAACTGTGACTGGAGATTCAATGAGTTTCCCAACCCAGCTGCCCATGCT CTCCATGTTACTTGTGTGGAGCTCATGGCCTTGGCAGTTTCAGGCAAAGAAGTTGGGAATGCCCTTCTA AATGTTGTCCTAAAAAGTCAGCCTTTAGTGCCAAGAGAGAACATTACAGCATGGATGAATGCAATTGGT TTGATCATCACTGCCCTACCAGAGCCATATTGGATTGTTCTTCATGATCGAATTGTGAGTGTCATCAGC AGCCCCAGCTTGACGTCTGAAACAGAGTGGGTTGGCTATCCATTCCGCCTCTTTGATTTCACTGCCTGT CATCAGTCCTACTCTGAGATGAGTTGTAGCTATACGTTAGCTCTTGCACATGCTGTGTGGCACCATTCT AGCATCGGACAACTTTCTCTCATTCCAAAGTTTCTTACTGAAGTACTTCTTCCTATAGTGAAGACCGAA TTCCAGTTGCTTTATGTATACCATCTTGTTGGACCATTTTTACAAAGATTTCAGCAAGAGAGAACTCGT TGTATGATAGAGATTGGTGTGGCGTTTTATGACATGCTGCTGAATGTTGACCAGTGTAGCACCCATTTA AATTACATGGATCCCATCTGTGACTTCCTCTATCACATGAAGTATATGTTTACTGGTGACAGCGTGAAA GAGCAAGTAGAGAAGATTATCTGTAACTTAAAACCAGCTTTAAAACTTCGTCTTCGATTCATCACACAC ATTAGCAAGATGGAGCCAGCTGCAGTGCCTCCACAAGCCATGAACAGTGGGTCTCCAGCACCTCAGTCT AATCAGGTTGACACTCTCACCTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001270522
Insert Size	4095 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001270522.1
RefSeq Size	4469 bp
RefSeq ORF	4095 bp
Locus ID	9439
UniProt ID	Q9ULK4
Protein Families	Druggable Genome, Transcription Factors
MW	156.1 kDa
Gene Summary	The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012] Transcript Variant: This variant (4) uses an alternate splice junction in the 3' end compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.

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