SERPINB6 (NM_001271825) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CAP; DFNB91; MSTP057; PI-6; PI6; PTI; SPI3
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC333124 representing NM_001271825. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGATGTTCTCGCAGAAGCAAATGGCACCTTTGCCTTAAACCTTTTGAAAACGCTGGGTAAAGACAAC TCGAAGAATGTGTTTTTCTCACCCATGAGCATGTCCTGTGCCCTGGCCATGGTCTACATGGGGGCAAAG GGAAACACCGCTGCACAGATGGCCCAGATACTTTCTTTCAATAAAAGTGGCGGTGGTGGAGACATCCAC CAGGGCTTCCAGTCTCTTCTCACCGAAGTGAACAAGACTGGCACGCAGTACTTGCTTAGGATGGCCAAC AGGCTCTTTGGGGAAAAGTCTTGTGATTTCCTCTCATCTTTTAGAGATTCCTGCCAAAAATTCTACCAA GCAGAGATGGAGGAGCTTGACTTTATCAGCGCCGTAGAGAAGTCCAGAAAACACATAAACACCTGGGTA GCTGAAAAGACAGAAGGTAAAATTGCGGAGTTGCTCTCTCCGGGCTCAGTGGATCCATTGACAAGGCTG GTTCTGGTGAATGCTGTCTATTTCAGAGGAAACTGGGATGAACAGTTTGACAAGGAGAACACCGAGGAG AGACTGTTTAAAGTCAGCAAGAATGAGGAGAAACCTGTGCAAATGATGTTTAAGCAATCTACTTTTAAG AAGACCTATATAGGAGAAATATTTACCCAAATCTTGGTGCTTCCATATGTTGGCAAGGAACTGAATATG ATCATCATGCTTCCGGACGAGACCACTGACTTGAGAACGGTGGAGAAAGAACTCACTTACGAGAAGTTC GTAGAATGGACGAGGCTGGACATGATGGATGAAGAGGAGGTGGAAGTGTCCCTCCCGCGGTTTAAACTA GAGGAAAGCTACGACATGGAGAGTGTCCTGCGCAACCTGGGCATGACTGATGCCTTCGAGCTGGGCAAG GCAGACTTCTCTGGAATGTCCCAGACAGACCTGTCTCTGTCCAAGGTCGTGCACAAGTCTTTTGTGGAG GTCAATGAGGAAGGCACGGAGGCTGCAGCCGCCACAGCTGCCATCATGATGATGCGGTGTGCCAGATTC GTCCCCCGCTTCTGCGCCGACCACCCCTTCCTTTTCTTCATCCAGCACAGCAAGACCAACGGGATTCTC TTCTGCGGCCGCTTTTCCTCTCCGTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001271825
Insert Size	1131 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001271825.1
RefSeq Size	1576 bp
RefSeq ORF	1131 bp
Locus ID	5269
UniProt ID	P35237
Protein Families	Druggable Genome
MW	42.6 kDa
Gene Summary	The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010] Transcript Variant: This variant (6) contains an alternate 5' UTR exon, compared to variant 1. Variants 1, 5 and 6 encode the same isoform (a).

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