MEMO1 (NM_001301833) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	C2orf4; CGI-27; MEMO; NS5ATP7
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC335172 representing NM_001301833. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGTCCAACCGAGTGGTCTGCCGAGAAGCCAGTCACGCCGGGAGCTGGTACACAGCCTCAGGACCGCAG CTGAATGCACAGCTAGAAGGTTGGCTTTCACAAGTACAGTCTACAAAAAGACCTGCTAGAGCCATTATT GCCCCCCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCT ATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGT GTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGTGGAAG ACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCT TATACAGCTAAAGCCATGGAAAGCCATAAGGATGAGTTTACCATTATTCCTGTACTGGTTGGAGCTCTG AGTGAGTCAAAAGAACAGGAATTCGGAAAACTCTTCAGTAAATATCTAGCGGATCCTAGTAATCTCTTT GTGGTTTCTTCTGATTTCTGCCATTGGGGTCAAAGGTTCCGTTACAGTTACTATGATGAATCCCAGGGG GAGATTTATAGATCCATTGAACATCTAGATAAAATGGGTATGAGTATTATAGAACAATTAGACCCTGTA TCTTTTAGCAATTACTTGAAGAAATACCATAATACTATATGTGGAAGACATCCCATTGGGGTGTTATTA AATGCTATCACAGAGCTCCAGAAGAATGGAATGAATATGAGTTTTTCGTTTTTGAATTATGCCCAGTCG AGCCAGTGTAGAAACTGGCAAGACAGTTCAGTGAGTTATGCAGCTGGAGCACTCACGGTCCACTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001301833
Insert Size	894 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001301833.1
RefSeq Size	1589 bp
RefSeq ORF	894 bp
Locus ID	51072
UniProt ID	Q9Y316
MW	33.7 kDa
Gene Summary	May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (1).

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