CNO6L (CNOT6L) (NM_001286790) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CCR4b
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC336772 representing NM_001286790. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGAGACTAATAGGGATGCCAAAGGAAAAATATGATCCTCCAGATCCTCGCAGAATTTATACCATCATG TCAGCAGAGGAGGTAGCCAATGGGAAAAAATCTCACTGGGCAGAATTAGAAATCTCGGGTAGAGTGCGG AGCCTAAGTACATCACTTTGGTCATTGACACACTTGACAGCGCTGCACCTAAATGACAATTACCTTAGT CGCATTCCACCTGATATTGCCAAGCTTCATAATCTGGTTTACCTGGATCTGTCATCCAATAAACTCAGA AGTTTACCAGCAGAACTAGGAAACATGGTGTCTCTCAGGGAATTGCTTTTAAATAACAATCTGTTACGG GTTTTGCCTTATGAACTTGGTCGGCTCTTCCAGCTACAAACTCTAGGTTTGAAAGGCAATCCTTTATCA CAGGATATTCTCAACTTATACCAGGACCCAGATGGAACCCGAAAGCTACTGAACTTCATGCTTGACAAT CTCGCAGTTCATCCAGAGCAGCTTCCTCCGAGGCCATGGATTACATTAAAAGAACGAGACCAAATTCTG CCGTCAGCATCATTCACGGTTATGTGTTACAATGTGTTATGTGATAAATACGCTACCCGGCAGCTATAT GGCTATTGCCCATCCTGGGCATTAAACTGGGAATACAGGAAAAAGGGAATTATGGAAGAAATTGTTAAC TGTGACGCAGATATCATTAGTCTTCAGGAAGTGGAAACAGAGCAATACTTCACTCTCTTTCTGCCAGCA TTGAAGGAGCGTGGATATGATGGATTTTTTTCTCCAAAGTCACGTGCCAAAATCATGTCTGAGCAGGAG AGAAAGCATGTAGATGGTTGTGCAATATTCTTCAAAACAGAAAAATTTACATTGGTGCAGAAGCATACA GTGGAATTTAACCAAGTGGCGATGGCTAATTCAGATGGATCCGAAGCTATGCTGAACAGAGTGATGACA AAAGATAACATTGGTGTCGCTGTGGTATTAGAGGTCCACAAAGAACTATTTGGAGCAGGTATGAAGCCT ATTCATGCTGCAGACAAACAGCTGCTTATAGTGGCAAATGCCCACATGCATTGGGACCCAGAGTATTCT GATGTGAAGCTCATCCAGACCATGATGTTTGTCTCAGAGGTTAAAAACATTCTGGAGAAAGCCTCTAGT AGGCCTGGAAGCCCAACTGCAGATCCTAATTCCATCCCGCTGGTGCTATGTGCAGATCTTAACTCATTG CCAGATTCAGGTGTTGTGGAATACTTAAGCAATGGAGGAGTAGCTGACAACCATAAAGACTTCAAGGAA CTAAGGTACAATGAGTGTCTTATGAACTTCAGCTGCAATGGAAAGAATGGAAGCTCAGAAGGGAGAATC ACACATGGCTTCCAACTTAAGAGCGCCTATGAAAATAACTTGATGCCTTACACCAATTACACCTTTGAT TTCAAAGGCGTGATTGACTACATTTTCTATTCCAAGACTCATATGAACGTGCTTGGTGTCCTGGGGCCT TTAGATCCTCAATGGCTGGTTGAGAACAACATCACTGGGTGTCCACACCCTCACATCCCTTCAGACCAC TTCTCACTGTTAACACAACTTGAACTCCACCCTCCACTCCTGCCTCTTGTCAATGGTGTTCACTTGCCT AATCGGAGGTAG
Restriction Sites	SgfI-MluI
ACCN	NM_001286790
Insert Size	1668 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001286790.1
RefSeq Size	8865 bp
RefSeq ORF	1668 bp
Locus ID	246175
UniProt ID	Q96LI5
Protein Pathways	RNA degradation
MW	63 kDa
Gene Summary	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3' UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

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