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Ppp1ca (NM_031868) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR204856L3V
- LentiORF®
-
Lenti ORF particles, Ppp1ca (Myc-DDK-tagged) - Mouse protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca), 200ul, >10^7 TU/mL
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CNY 7,410.00
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规格
| Cited in 1 publication. |
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经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Ppp1ca (NM_031868) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | dism2; Ppp1c |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_031868 |
| ORF Size | 993 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR204856).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_031868.2, NP_114074.1 |
| RefSeq Size | 1363 bp |
| RefSeq ORF | 993 bp |
| Locus ID | 19045 |
| Gene Summary | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates CENPA (By similarity). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity).[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
,null,
Nature Communications
,PubMed ID 30158517
[Ppp1ca]
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