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Ackr1 (NM_010045) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR204947L4V
- LentiORF®
-
Lenti ORF particles, Darc (GFP-tagged) - Mouse Duffy blood group, chemokine receptor (Darc), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Ackr1 (NM_010045) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AA162249; CCBP1; CD234; Darc; Dfy; ESTM35; FY; GPD |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_010045 |
| ORF Size | 1005 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR204947).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_010045.2 |
| RefSeq Size | 1158 bp |
| RefSeq ORF | 1005 bp |
| Locus ID | 13349 |
| Gene Summary | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).[UniProtKB/Swiss-Prot Function] |
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