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Rnf34 (NM_030564) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR205854L4V
- LentiORF®
-
Lenti ORF particles, Rnf34 (GFP-tagged) - Mouse ring finger protein 34 (Rnf34), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Rnf34 (NM_030564) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AW061037; AW536122; BC004042; C88279; RIFF |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_030564 |
| ORF Size | 1131 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR205854).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_030564.1, NP_085041.1 |
| RefSeq Size | 1980 bp |
| RefSeq ORF | 1131 bp |
| Locus ID | 80751 |
| Gene Summary | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation.[UniProtKB/Swiss-Prot Function] |
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