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Mavs (NM_144888) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR208088L4V
- LentiORF®
-
Lenti ORF particles, Mavs (GFP-tagged) - Mouse mitochondrial antiviral signaling protein (Mavs), nuclear gene encoding mitochondrial protein, transcript variant 1, 200ul, >10^7 TU/mL
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CNY 10,640.00
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Specifications
| Product Data | |
| Product Name | Mavs (NM_144888) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | cardif; D430028G21Rik; IPS-1; Visa |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_144888 |
| ORF Size | 1512 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR208088).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_144888.1 |
| RefSeq Size | 3099 bp |
| RefSeq ORF | 1512 bp |
| Locus ID | 228607 |
| Gene Summary | Required for innate immune defense against viruses (PubMed:24037184). Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5) (PubMed:24037184). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (By similarity). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (By similarity). May activate the same pathways following detection of extracellular dsRNA by TLR3 (By similarity). May protect cells from apoptosis (By similarity).[UniProtKB/Swiss-Prot Function] |
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