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Shmt2 (NM_028230) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR208109L4V
- LentiORF®
-
Lenti ORF particles, Shmt2 (GFP-tagged) - Mouse serine hydroxymethyltransferase 2 (mitochondrial) (Shmt2), nuclear gene encoding mitochondrial protein, 200ul, >10^7 TU/mL
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CNY 10,735.00
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Specifications
| Product Data | |
| Product Name | Shmt2 (NM_028230) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2700043D08Rik; AA408223; AA986903 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_028230 |
| ORF Size | 1515 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR208109).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_028230.3, NP_082506.1 |
| RefSeq Size | 2305 bp |
| RefSeq ORF | 1515 bp |
| Locus ID | 108037 |
| Gene Summary | Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By similarity). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29452640). Associates with mitochondrial DNA (By similarity). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (By similarity).[UniProtKB/Swiss-Prot Function] |
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