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Parn (NM_028761) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR209527L3V
- LentiORF®
-
Lenti ORF particles, Parn (Myc-DDK-tagged) - Mouse poly(A)-specific ribonuclease (deadenylation nuclease) (Parn), 200ul, >10^7 TU/mL
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CNY 10,925.00
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Specifications
| Product Data | |
| Product Name | Parn (NM_028761) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 1200003I18Rik; DAN |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_028761 |
| ORF Size | 1875 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR209527).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_028761.1, NP_083037.1 |
| RefSeq Size | 2902 bp |
| RefSeq ORF | 1875 bp |
| Locus ID | 74108 |
| Gene Summary | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3' UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity). Also able to recognize poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to leading to microRNAs degradation or snoRNA increased stability (By similarity).[UniProtKB/Swiss-Prot Function] |
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